The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Shatverian G.A.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. B.V. Petrovskogo RAMN

Chardarov N.K.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Nikoda V.V.

B.V. Petrovsky National Research Centre of Surgery, Moscow

Bagmet N.N.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Tadzhibova I.M.

Petrovsky National Research Centre of Surgery, Moscow, Russia

Lishova E.A.

Petrovsky Russian Research Centre of Surgery, Moscow, Russia

Ratnikova N.P.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN

Karagyozyan G.A.

Department of liver, biliary and pancreatic surgery, Petrovsky Russian Research Center for Surgery, Moscow, Russia

Short-term results of pancreatoduodenectomy in patients over 70 years old

Authors:

Shatverian G.A., Chardarov N.K., Nikoda V.V., Bagmet N.N., Tadzhibova I.M., Lishova E.A., Ratnikova N.P., Karagyozyan G.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(1): 25‑32

DOI: 10.17116/hirurgia202001125

Read: 9699 times

Download PDF (RU)
Download PDF
Contact the author
Table of contents

SHORT-TERM RESULTS OF PANCREATODUODENECTOMY IN PATIENTS OVER 70 YEARS OLD
SHORT-TERM RESULTS OF PANCREATODUODENECTOMY IN PATIENTS OVER 70 YEARS OLD

To cite this article:

Shatverian GA, Chardarov NK, Nikoda VV, et al. . Short-term results of pancreatoduodenectomy in patients over 70 years old. Pirogov Russian Journal of Surgery. 2020;(1):25‑32. (In Russ., In Engl.)
https://doi.org/10.17116/hirurgia202001125

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Safety profile of pressurized intraperitoneal aero­sol chemotherapy in the treatment of ovarian cancer. P.A. Herzen Journal of Onco­logy. 2024;(5):25-30
Right-sided hemi­hepatectomy after endo­vascular vascular isolation of the right lobe of the liver. P.A. Herzen Journal of Onco­logy. 2024;(5):45-49
Pancreaticoduodenectomy combined with multivisceral rese­ctions. Piro­gov Russian Journal of Surgery. 2024;(11):77-83
Intracranial hype­rtension in hemo­rrhagic stroke: a single-center retrospective study. Russian Journal of Anesthesiology and Reanimatology. 2024;(6):23-29
Treatment of postoperative complications in cardiothoracic surgery: single-center 10-year expe­rience. Piro­gov Russian Journal of Surgery. 2024;(12-2):66-71
Cere­bral protection in transcatheter aortic valve implantation. Piro­gov Russian Journal of Surgery. 2024;(12-2):150-158
COVID-19 and pneumonia — mortality and coding features (example of the Moscow region). Medi­cal Technologies. Asse­ssment and Choice. 2024;(4):30-39
Capsular contracture after reco­nstructive plastic surgery for breast cancer. P.A. Herzen Journal of Onco­logy. 2024;(6):78-83
Short- and mid-term outcomes after posterolateral endo­scopic discectomy in patients with lumbosacral junction disc herniations. Piro­gov Russian Journal of Surgery. 2024;(12):52-59
Complications after Laser Treatment. Journal of Venous Diso­rders. 2024;(4):317-327
Abstract:

Objective — to analyze the immediate results of PDE in patients younger and older 70 years. Material and methods. The study included patients who underwent PDE for various indications from March 2010 to February 2019. All patients are divided into 2 groups: <70 years old and ≥70 years old. Primary endpoints were postoperative mortality and complication rate. Results. There were 110 procedures within 9 years. There were 93 patients aged <70 years (group 1) and 17 patients aged ≥70 years (group 2). ASA (American Society of Anesthesiologists) and PMP scores (Preoperative Mortality Predictor) were higher in group 2: 3 (2—3) vs 2 (1—3) (p=0,002) and 12 (6—15) vs 6.5 (5—15) (p<0.001), respectively. Mortality rate was higher in group 2 (11.7% vs. 3.2%) without statistical significance (p=0.16). Overall morbidity (72% vs 76%; p=1.0), incidence of major complications grade ≥IIIa (29% vs 29%), delayed gastric emptying B/C (17.2% vs 17.6%), pancreatic fistula grade B/C (23.6% vs 35.3%, p=0.3), biliary fistula grade B/C (7.5% vs 11.8%; p=0.62), postoperative hospital-stay [22 (8—165) days vs 23 (9—71) days; p=0.92] were comparable in both groups. Conclusion. Short-term results of PDE in patients aged <70 and ≥70 years are comparable despite higher ASA and PMP scores in the group 2. General status and concomitant diseases should be considered during selection of patients with resectable tumors for PDE. Age per se is not a contraindication for surgery.

Keywords:

pancreatoduodenectomy
mortality
complications
advanced age

Authors:

Shatverian G.A.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. B.V. Petrovskogo RAMN

Chardarov N.K.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Nikoda V.V.

B.V. Petrovsky National Research Centre of Surgery, Moscow

Bagmet N.N.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Tadzhibova I.M.

Petrovsky National Research Centre of Surgery, Moscow, Russia

Lishova E.A.

Petrovsky Russian Research Centre of Surgery, Moscow, Russia

Ratnikova N.P.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. akad. B.V. Petrovskogo RAMN

Karagyozyan G.A.

Department of liver, biliary and pancreatic surgery, Petrovsky Russian Research Center for Surgery, Moscow, Russia

Close metadata

References:

  1. Vin Y, Sima CS, Getrajdman GI, et al. Management and outcomes of postpancreatectomy fistula, leak, and abscess: results of 908 patients resected at a single institution between 2000 and 2005. J Am Coll Surg. 2008;207(4):490-498. https://doi.org/10.1016/j.jamcollsurg.2008.05.003
  2. Winter JM, Cameron JL, Campbell KA, et al. 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006;10(9):1199-1210; discussion 1210-1211. https://doi.org/10.1016/j.gassur.2006.08.018
  3. Schmidt CM, Powell ES, Yiannoutsos CT, et al. Pancreaticoduodenectomy: a 20-year experience in 516 patients. Arch Surg Chic Ill 1960. 2004;139(7):718-725; discussion 725-727. https://doi.org/10.1001/archsurg.139.7.718
  4. Behrman SW, Rush BT, Dilawari RA. A modern analysis of morbidity after pancreatic resection. Am Surg. 2004;70(8):675-682; discussion 682-683.
  5. Makary MA, Winter JM, Cameron JL, et al. Pancreaticoduodenectomy in the very elderly. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006;10(3):347-356. https://doi.org/10.1016/j.gassur.2005.12.014
  6. Riall TS. What is the effect of age on pancreatic resection? Adv Surg. 2009;43:233-249.
  7. Solaini L, Jamieson NB, Metcalfe M, et al. Outcome after surgical resection for duodenal adenocarcinoma in the UK. Br J Surg. 2015;102(6):676-681. https://doi.org/10.1002/bjs.9791
  8. Klein F, Jacob D, Bahra M, et al. Prognostic factors for long-term survival in patients with ampullary carcinoma: the results of a 15-year observation period after pancreaticoduodenectomy. HPB Surg World J Hepatic Pancreat Biliary Surg. 2014;2014:970234. https://doi.org/10.1155/2014/970234
  9. Dindo D, Demartines N, Clavien P-A. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-213. https://doi.org/10.1097/01.sla.0000133083.54934.ae
  10. Wente MN, Bassi C, Dervenis C, et al. Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2007;142(5):761-768. https://doi.org/10.1016/j.surg.2007.05.005
  11. Bassi C, Marchegiani G, Dervenis C, et al. International Study Group on Pancreatic Surgery (ISGPS). The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery. 2017 Mar;161(3):584-591. https://doi.org/10.1016/j.surg.2016.11.014
  12. Wente MN, Veit JA, Bassi C, et al. Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery. 2007;142(1):20-25. https://doi.org/10.1016/j.surg.2007.02.001
  13. Saklad M MD. Grading of patients for surgical procedures. Anesthesiol J Am Soc Anesthesiol. 1941;2(3):281-284.
  14. Vaid S, Bell T, Grim R, Ahuja V. Predicting risk of death in general surgery patients on the basis of preoperative variables using American College of Surgeons National Surgical Quality Improvement Program data. Perm J. 2012;16(4):10-17. https://doi.org/10.7812/tpp/12-019
  15. Goldman L, Caldera DL, Nussbaum SR, et al. Multifactorial index of cardiac risk in noncardiac surgical procedures. N Engl J Med. 1977;297(16):845-850. https://doi.org/10.1056/NEJM197710202971601
  16. Callery MP, Pratt WB, Kent TS, Chaikof EL, Vollmer CM. A prospectively validated clinical risk score accurately predicts pancreatic fistula after pancreatoduodenectomy. J Am Coll Surg. 2013;216(1):1-14. https://doi.org/10.1016/j.jamcollsurg.2012.09.002
  17. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59(4):225-249. https://doi.org/10.3322/caac.20006
  18. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5-29. https://doi.org/10.3322/caac.21254
  19. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer Oxf Engl. 2013;49(6):1374-1403. https://doi.org/10.1016/j.ejca.2012.12.027
  20. Yancik R, Ries LAG. Cancer in older persons: an international issue in an aging world. Semin Oncol. 2004;31(2):128-136.
  21. Davydov MI, Aksel’ EM. Statistika zlokachestvennyh novoobrazovanij v Rossii i stranah SNG v 2012 g. M.: Izdatel’skaya gruppa RONC6 2014. (In Russ.)
  22. Sohn TA, Yeo CJ, Cameron JL, et al. Should pancreaticoduodenectomy be performed in octogenarians? J Gastrointest Surg Off J Soc Surg Aliment Tract. 1998;2(3):207-216.
  23. Scurtu R, Bachellier P, Oussoultzoglou E, Rosso E, Maroni R, Jaeck D. Outcome after pancreaticoduodenectomy for cancer in elderly patients. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2006;10(6):813-822. https://doi.org/10.1016/j.gassur.2005.12.010
  24. Renz BW, Khalil PN, Mikhailov M, et al. Pancreaticoduodenectomy for adenocarcinoma of the pancreatic head is justified in elderly patients: A Retrospective Cohort Study. Int J Surg Lond Engl. 2016;28:118-125. https://doi.org/10.1016/j.ijsu.2016.02.064
  25. Turrini O, Paye F, Bachellier P, et al. Pancreatectomy for adenocarcinoma in elderly patients: postoperative outcomes and long term results: a study of the French Surgical Association. Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2013;39(2):171-178. https://doi.org/10.1016/j.ejso.2012.08.017
  26. Watanabe J, Hanaki T, Arai Y, et al. Perioperative Outcomes after Pancreaticoduodenectomy in Elderly Patients. Hepatogastroenterology. 2015;62(139):590-594.
  27. Kow AWC, Sadayan NA, Ernest A, et al. Is pancreaticoduodenectomy justified in elderly patients? Surg J R Coll Surg Edinb Irel. 2012;10(3):128-136. https://doi.org/10.1016/j.surge.2011.02.005
  28. Brozzetti S, Mazzoni G, Miccini M, et al. Surgical treatment of pancreatic head carcinoma in elderly patients. Arch Surg Chic Ill 1960. 2006;141(2):137-142. https://doi.org/10.1001/archsurg.141.2.137
  29. Riediger H, Krueger CM, Makowiec F, Adam U. Impact of Age and Comorbidity on Perioperative Mortality after 250 Pancreatic Head Resections. Zentralbl Chir. 2016;141(3):270-276. https://doi.org/10.1055/s-0041-111520
  30. Lahat G, Sever R, Lubezky N, et al. Pancreatic cancer: surgery is a feasible therapeutic option for elderly patients. World J Surg Oncol. 2011;9:10. https://doi.org/10.1186/1477-7819-9-10
  31. Adham M, Bredt LC, Robert M, et al. Pancreatic resection in elderly patients: should it be denied? Langenbecks Arch Surg. 2014;399(4):449-459. https://doi.org/10.1007/s00423-014-1183-9
  32. Nayar P, Chandak A, Yu F, Sayles H, Ganti AK. Mortality following pancreatectomy for elderly rural veterans with pancreatic cancer. J Geriatr Oncol. 2017;8(4):284-288. https://doi.org/10.1016/j.jgo.2017.05.001
  33. Sukharamwala P, Prashant S, Thoens J, et al. Advanced age is a risk factor for post-operative complications and mortality after a pancreaticoduodenectomy: a metaanalysis and systematic review. HPB. 2012;14(10):649-657. https://doi.org/10.1111/j.1477-2574.2012.00506.x
  34. Kim SY, Weinberg L, Christophi C, Nikfarjam M. The outcomes of pancreaticoduodenectomy in patients aged 80 or older: a systematic review and metaanalysis. HPB. 2017;19(6):475-482. https://doi.org/10.1016/j.hpb.2017.01.018
  35. Shamali A, De’Ath HD, Jaber B, et al. Elderly patients have similar short term outcomes and five-year survival compared to younger patients after pancreaticoduodenectomy. Int J Surg Lond Engl. 2017;45:138-143. https://doi.org/10.1016/j.ijsu.2017.07.106
  36. Kim SY, Fink MA, Perini M, et al. Age 80 years and over is not associated with increased morbidity and mortality following pancreaticoduodenectomy. ANZ J Surg. 2018;88(5):E445-E450. https://doi.org/10.1111/ans.14039
  37. Pratt WB, Callery MP, Vollmer CM. Risk prediction for development of pancreatic fistula using the ISGPF classification scheme. World J Surg. 2008;32(3):419-428. https://doi.org/10.1007/s00268-007-9388-5
  38. Tani M, Kawai M, Hirono S, et al. A pancreaticoduodenectomy is acceptable for periampullary tumors in the elderly, even in patients over 80 years of age. J Hepatobiliary Pancreat Surg. 2009;16(5):675-680. https://doi.org/10.1007/s00534-009-0106-6
  39. Belyaev O, Herzog T, Kaya G, et al. Pancreatic surgery in the very old: face to face with a challenge of the near future. World J Surg. 2013;37(5):1013-1020. https://doi.org/10.1007/s00268-013-1944-6
  40. Shimamoto C, Hirata I, Hiraike Y, Takeuchi N, Nomura T, Katsu K. Evaluation of gastric motor activity in the elderly by electrogastrography and the (13)C-acetate breath test. Gerontology. 2002;48(6):381-386. https://doi.org/10.1159/000065500
  41. Hatzaras I, Schmidt C, Klemanski D, et al. Pancreatic resection in the octogenarian: a safe option for pancreatic malignancy. J Am Coll Surg. 2011;212(3):373-377. https://doi.org/10.1016/j.jamcollsurg.2010.10.015
  42. Oguro S, Shimada K, Kishi Y, Nara S, Esaki M, Kosuge T. Perioperative and long-term outcomes after pancreaticoduodenectomy in elderly patients 80 years of age and older. Langenbecks Arch Surg. 2013;398(4):531-538. https://doi.org/10.1007/s00423-013-1072-7
  43. Begg CB, Cramer LD, Hoskins WJ, Brennan MF. Impact of hospital volume on operative mortality for major cancer surgery. JAMA. 1998;280(20):1747-1751. https://doi.org/10.1001/jama.280.20.1747
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.