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Kosinets V.A.

Vitebskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Osochuk S.S.

Tsentral'naia nauchno-issledovatel'skaia laboratoriia Vitebskogo gosudarstvennogo meditsinskogo universiteta, Respublika Belarus'

Iarotskaia N.N.

Tsentral'naia nauchno-issledovatel'skaia laboratoriia Vitebskogo gosudarstvennogo meditsinskogo universiteta, Respublika Belarus'

The correction of the mitochondrial lipid spectre in liver by the experimental peritoniti

Authors:

Kosinets V.A., Osochuk S.S., Iarotskaia N.N.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2012;(2): 60‑63

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THE CORRECTION OF THE MITOCHONDRIAL LIPID SPECTRE IN LIVER BY THE EXPERIMENTAL PERITONITI
THE CORRECTION OF THE MITOCHONDRIAL LIPID SPECTRE IN LIVER BY THE EXPERIMENTAL PERITONITI

To cite this article:

Kosinets VA, Osochuk SS, Iarotskaia NN. The correction of the mitochondrial lipid spectre in liver by the experimental peritoniti. Pirogov Russian Journal of Surgery. 2012;(2):60‑63. (In Russ.)

Подписка 2025-2 (Pirogov Russian Journal of Surgery)
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The experiment has been carried out on 55 male rabbits of chinchilla breed. For the first time in comparative aspect influence of preparations "Citoflavin" and "Neoton" on a phospholipid spectrum of liver mitochondrial membranes is studied at an experimental widespread purulent peritonitis. It is established that in the postoperative period "Citoflavin", which contains amber acid, influences on phospholipid structure of mitochondria of animals with a widespread purulent peritonitis by percentage decrease of lisophosphatides, level increase of polyglycerophosphatide and cardiolipin more effectively.

Keywords:

widespread purulent peritonitis
"Citoflavin"
"Neoton"
mitochondria
phospholipids
cardiolipin

Authors:

Kosinets V.A.

Vitebskiĭ gosudarstvennyĭ meditsinskiĭ universitet

Osochuk S.S.

Tsentral'naia nauchno-issledovatel'skaia laboratoriia Vitebskogo gosudarstvennogo meditsinskogo universiteta, Respublika Belarus'

Iarotskaia N.N.

Tsentral'naia nauchno-issledovatel'skaia laboratoriia Vitebskogo gosudarstvennogo meditsinskogo universiteta, Respublika Belarus'

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  2. Gostishchev V.K.., Sazhin V.P., Avdovenko A.L. Peritonit. M: GEOTAR-Media 2002; 238.
  3. Eryukhin I.A., Shlyapnikov S.A., Efimova I.S. Peritonit i abdominal'nyi sepsis. Infektsii v khirurgii 2004; 2: 2-8.
  4. Efimenko N.A. i dr. Spetsial'nye nutritsevtiki v lechenii sindroma kishechnoi nedostatochnosti u bol'nykh peritonitom. Vestn intensiv ter 2005; 6: 33-35.
  5. Keits M. Tekhnika lipidologii. M: Mir 1975; 76: 138-140, 310-311.
  6. Kosinets A.N., Struchkov Yu.V. Infektsiya v khirurgii: rukovodstvo. Vitebsk 2004; 510.
  7. Pokrovskii A.A. Biokhimicheskie metody issledovaniya. M: Meditsina 1969; 477.
  8. Popova. T.S. i dr. Nutritivnaya podderzhka bol'nykh v kriticheskikh sostoyaniyakh. M: M-Vesti 2002; 319.
  9. Savel'ev B.C. Peritonit: praktich. rukov. Pod red. V.S. Savel'eva, B.R. Gel'fanda, M.I. Filimonova. M: Litterra 2006; 208.
  10. Shurkalin B.K. Khirurgicheskie aspekty lecheniya rasprostranennogo peritonita. Khirurgiya 2007; 2: 24-28.
  11. Chicco A., Sparagna G. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Am J Physiol Cell Physiol 2007; 292: C33-C44.
  12. Deitch E.A. Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings. Surgery 2002; 131: 241-244.
  13. Gornal A.C., Bardawill C.J., David M.M. Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949; 177: 751-766.
  14. Johnson D., Lardy H. Methods Enzymol 1967; 10: 94-96.
  15. Kavanagh N.I., Ainscow E.K., Brand M.D. Calcium Regulation of Oxidative Phosphorilation in Rat Sceletal Muscle Mitochondria. Biochim Biophys Acta 2000; 1457: 57-70.
  16. Mileykovskaya E., Zhang M., Dowhan W. Cardiolipin in energy transducing membranes. Biochemistry (Mosc) 2005; 70: 154-158.
  17. Ott M. et al. Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci USA 2002; 99: 1259-1263.
  18. Svanborg A., Svennercholm L. Plasma total lipid cholesterol, triglycerides, phospholipids and free acids in a healthy scandinavian men. Acta med scand 1961; 169: 43-46.
  19. Vercesi A.E. et al. The Role of Reactive Oxygen Species in Mitochondrial Permeability Transition. Biosci Rep 1997; 17: 43-52.

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