The aim of the work was analysis of treatment of 560 patients with a gastrointestinal bleeding from acute ulcers. For estimation of patients was used universal integrated scale APACHE III. Tactics of treatment depend on secretory functions of a stomach and group of polyorganical difunction. At 428 (76,5%) patients with acute ulcers on the background increase secretion of stomach was treatment antysecretion therapy. At 132 (23,5%) patients with acute ulcers on the background of normal ore decrease secretion of stomach was treatment Cytoflavin - the metabolic preparation possessing antyoxidation, cytoprotection and immunomodulaytion activity. For studying antyoxidation and antihypoxation actions of Cytoflavin estimated of microcirculation mucous of a stomach with the laser Doppler floymetrya before course of treatment, observed increase of index efficiency of microcirculation and increase a blood-groove in a stomach at patients with acute peptic ulcers on a background of treatment of Cytoflavin. After course of treatment of Cytoflavin decrease in points on system APACHE III on 5,5-25% at all patients that has led to decrease mortality on 20% in this group of patients.