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Chernov V.N.

Kafedra obshcheĭ khirurgii Rostovskogo gosudarstvennogo meditsinskogo universiteta

Mareev D.V.

City Clinical hospital №1 named after N.A. Semashko, Rostov-on-Don, Russia

Treatment of abdominal sepsis

Authors:

Chernov V.N., Mareev D.V.

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Journal: Pirogov Russian Journal of Surgery. 2010;(8): 44‑47

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To cite this article:

Chernov VN, Mareev DV. Treatment of abdominal sepsis. Pirogov Russian Journal of Surgery. 2010;(8):44‑47. (In Russ.)

Подписка 2025 (Pirogov Russian Journal of Surgery)
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129 patients with abdominal sepsis were divided in two groups. Patients of the 1st group (n=68) were treated according to the accepted standard. Patients of the 2nd group received the same treatment, but after germ translocation to the abdominal cavity and blood, immunoglobulin blood titer detection, drugs were administered through the cannulated umbilical vein straight to the portal system. Blood samples from ulnar and portal veins and microbiological samples from gut lumen showed similar results in patients with sepsis, proving the phenomenon of bacterial translocation. Histological analysis of liver biopsy demonstrated affection of both hepatocites and reticuloendothelial system of the liver by sepsis. The use of intraportal drug administration decreased mortality from 27.9% (1st group) to 16.3% (2nd group).

Keywords:

abdominal sepsis
bacterial translocation
intraportal drug administration

Authors:

Chernov V.N.

Kafedra obshcheĭ khirurgii Rostovskogo gosudarstvennogo meditsinskogo universiteta

Mareev D.V.

City Clinical hospital №1 named after N.A. Semashko, Rostov-on-Don, Russia

List of references:

  1. Savel'ev V.S., Kubyshkin V.A. Pankreonekroz. Sostoyanie i perspektiva. Khirurgiya 1993; 6: 22-28.
  2. Savel'ev V.S., Filimonov M.I., Gel'fand B.R., Burnevich S.Z. Pankreonekroz i pankreatogennyi sepsis. Sostoyanie problemy. Annaly khir 2003; 1: 12-20.
  3. Rybakov G.S., Dibirov M.D., Briskin B.S., Khalidov O.Kh. Pankreatogennyi sepsis. Novye tekhnologii v khirurgii. Sb. trudov mezhdunarodnogo khirurgicheskogo kongressa. Rostov-na-Donu 2005; 90.
  4. Chernov V.N., Efanov S.Yu., Rodakov A.V. Lechenie rasprostranennogo peritonita s makrofagal'noi pechenochnoi nedostatochnost'yu. Materialy pervogo s''ezda khirurgov Yuzhnogo federal'nogo okruga. Rostov-na-Donu 2007; 58-59.
  5. Akcay M.N., Capan M.Y., Gundogdu C. et al. Bacterial translocation in experimental intestinal obstruction. J Int Med Res 1996; 24: 1: 17-26.
  6. Bone R.C. Sepsis and septic shock. Freshening course of the lectures 9th Europen Congress of Anaestesiology, Jerusalem, Israel 1994; 125-139.
  7. Bone R.C. Sepsis: A New Hypothesis for Pathogenesis of Disease Process. Chest 1997; 112: 235-243.
  8. Chen X., Ran R. Rhubarb decoction prevents intestinal bacterial translocation during necrotic pancreatitis. Hua Hsi I Ko Ta Hsueh Pao 1996; 27: 4: 418-421.

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