Effects of mexidol in patients with chronic brain ischemia and chronic heart failure (II-III functional class)

Shchulkin A.V.; Kazakhmedov E.R.; Galochkin S.A.; Tolkacheva V.V.; Kobalava Z.D.

doi:https://doi.org/10.17116/kardio202013051427

Shchulkin A.V.

Pavlov Ryazan State Medical University

Kazakhmedov E.R.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0002-6274-8933

Galochkin S.A.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0001-7370-8606

Tolkacheva V.V.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0001-6847-8797

Kobalava Z.D.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0002-5873-1768

Effects of mexidol in patients with chronic brain ischemia and chronic heart failure (II-III functional class)

Authors:

Shchulkin A.V., Kazakhmedov E.R., Galochkin S.A., Tolkacheva V.V., Kobalava Z.D.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(5): 427‑434

DOI: 10.17116/kardio202013051427

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To cite this article:

Shchulkin AV, Kazakhmedov ER, Galochkin SA, Tolkacheva VV, Kobalava ZD. Effects of mexidol in patients with chronic brain ischemia and chronic heart failure (II-III functional class). Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(5):427‑434. (In Russ.)
https://doi.org/10.17116/kardio202013051427

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

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AIM

To study the effect of mexidol on N-terminal pro B-type natriuretic peptide (NT-proBNP), markers of oxidative stress, inflammatory reaction and endothelial dysfunction in patients with chronic brain ischemia and chronic heart failure II-III NYHA functional class while 13 weeks of sequential intravenous and oral therapy with mexidol and standard therapy.

MATERIAL AND METHODS

Study included 44 patients with chronic brain ischemia and chronic heart failure II-III NYHA functional class with ejection fraction less 50%. Mean age: 65.5±11.8 years, 75% men. 21 patients of group mexidol plus standard therapy of chronic heart failure received mexidol at a dose of 1000 mg/day by intravenous infusion for 7 days followed by oral doses of 250 mg three times a day for twelve weeks, 23 patients received standard therapy. 34 patients completed the trial, in 10 patient the final visit was performed as telephone call due to epidemiologic situation. Concentration of N-terminal pro B-type natriuretic peptide (NT-proBNP), markers of oxidative stress (malonic dialdehyde (MDA), superoxide dismutase (SOD)), inflammatory reaction (C-reactive protein (CRP), tumor necrosis factor α (TNFα)), homocysteine and cystatin C were examined in blinded manner in all patients initially, on day 7 and week 13.

RESULTS

Statistically significant more prominent decrease of NT-proBNP, MDA, CRP and TNFα and increase of SOD by day 7 and week 13 were observed in patients treated with mexidol along with standard therapy in comparison with group treated with standard therapy.

CONCLUSION

Mexidol added to standard therapy of patients with chronic brain ischemia and chronic heart failure II-III functional class decreases concentration of NT-proBNP, has proven antioxidant activity, decreases the degree of inflammatory reaction, slows down the increase of homocysteine, does not influence the kidney function (by measurement of cystatin C).

Keywords:

chronic brain ischemia

heart failure

oxidative stress

antioxidants

N-terminal pro B-type natriuretic peptide (NT-proBNP)

malonic dialdehyde

superoxide dismutase

CRP

TNFα

ethyl-methyl-hydroxipyridin succinate

mexidol

Authors:

Shchulkin A.V.

Pavlov Ryazan State Medical University

Kazakhmedov E.R.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0002-6274-8933

Galochkin S.A.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0001-7370-8606

Tolkacheva V.V.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0001-6847-8797

Kobalava Z.D.

Peoples’ Friendship University of Russia named after Patris Lumumber

ORCID: 0000-0002-5873-1768

Received:

21.08.2020

Accepted:

10.09.2020

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