Aim — to evaluate treatment, immediate and long-term outcomes in elderly and senile patients with atrial fibrillation (AF). Material and methods. There were 234 patients with non-valvular AF. Patients were divided into groups depending on age: group 1 — up to 60 years, group 2 — from 60 to 74 years, group 3 — 75 years and older. Anamnesis, cardiovascular diseases (CVD) and their risk factors were analyzed. Results. There were 50% of men among 234 patients. Median of age was 72 (65; 79) years. Groups significantly differed by gender. There were 19.4% of women among patients under 60 years old. In groups 2 and 3, women prevailed (56 and 53.4%, respectively, p<0.001). There were less number of smokers in groups 2 and 3 (14 and 4.9%, respectively, p=0.003). Arterial hypertension was more common in advanced age patients (97 and 67.7%, respectively; p<0.001). There were no significant differences in other risk factors of CVD. Signs of chronic heart failure were significantly more common in elderly patients (51.5%; p=0.012). Advanced age was associated with significant increase of left ventricular myocardial mass index and indexed volume of the left atrium (p<0.001). Chronic kidney disease (CKD) was noted among patients. CKD grade 4 was significantly more common in elderly patients (10.7%; p=0.023). Anticoagulants were prescribed much more frequently among elderly patients than in younger patients (58 and 32.3%; p=0.042). Conclusion. There were significant differences in the prevalence of CKD grade 4. It is much more common in advanced age patients that requires careful selection of anticoagulant therapy. Incidence of outpatient administration of anticoagulants was small among advanced age patients, since formal contraindications were absent.