The role of imbalance of myocardial cell adhesion proteins in cardiac arrhythmia and heart failure

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A review of the literature data on the role of imbalance of cellular adhesion proteins (CAP) of the heart in the development of cardiac arrhythmias and heart failure. The CAPS of the intercalated discs belonging to the cadherin and desmin groups provide a mechanical connection of cardiomyocytes, proteins from the connexin group are responsible for the transmission of an electrical impulse. The imbalance of CAP has mainly a hereditary origin and is accompanied by the destruction of intercalated discs, blockage of impulse transmission with the development of electrical instability of the myocardium and cardiac arrhythmias, including ventricular and atrial fibrillation. This is the case with cardiomyopathies, coronary heart disease. Endothelial dysfunction also plays an essential role in atrial fibrillation, which is associated with an imbalance in the CAP of the endothelial lining of the endocardium and blood vessels.

Keywords:

cell adhesion proteins

intercalated discs

ventricular fibrillation

atrial fibrillation

cardiomyopathies

Authors:

Kakturskiy L.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

ORCID: 0000-0001-7896-2080

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

ORCID: 0000-0003-2052-914X

Gioeva Z.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-5456-8692

Gutyrchik N.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery;
Patrice Lumumba Peoples’ Friendship University of Russia

ORCID: 0000-0002-2352-278X

Received:

11.04.2024

Accepted:

26.06.2024

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