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Sulimov V.A.

Pervyĭ MGMU im. I.M. Sechenova;
Moskovskiĭ NII pediatrii i detskoĭ khirurgii

Moroz E.V.

GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova", fakul'tetskaia terapevticheskaia klinika im. V.N. Vinogradova, universitetskaia klinicheskaia bol'nitsa #1, Moskva

Clinical value of resistance to antithrombotic drugs in coronary artery stenting

Authors:

Sulimov V.A., Moroz E.V.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(3): 9‑12

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To cite this article:

Sulimov VA, Moroz EV. Clinical value of resistance to antithrombotic drugs in coronary artery stenting. Russian Journal of Cardiology and Cardiovascular Surgery. 2012;5(3):9‑12. (In Russ.)

Подписка 2025 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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Risk of cardiovascular complications depending on the level of platelet aggregation was studied in patients after coronary artery stenting. 100 patients with stable angina of II-IV functional class undergoing coronary artery stenting were included in the study. Platelet aggregation was estimated using optical aggregometry. In case of resistance to clopidogrel its dose was increased up to 150 mg a day. Clinical outcomes were evaluated after 6 and 12 months. It is ascertained that resistance to clopidogrel increases risk for unfavorable cardiovascular outcomes after 6 months by 42% and after 12 months - by 45%. Estimation of platelet aggregation activity is reasonable to perform before coronary angioplasty and in early terms after procedure to evaluate the efficacy of antiaggregant treatment.

Keywords:

coronary heart disease
coronary stenting
platelet aggregation
resistance
acetylsalicilic acid
clopidogrel.

Authors:

Sulimov V.A.

Pervyĭ MGMU im. I.M. Sechenova;
Moskovskiĭ NII pediatrii i detskoĭ khirurgii

Moroz E.V.

GBOU VPO "Pervyĭ MGMU im. I.M. Sechenova", fakul'tetskaia terapevticheskaia klinika im. V.N. Vinogradova, universitetskaia klinicheskaia bol'nitsa #1, Moskva

List of references:

  1. Metodiki klinicheskikh issledovanii. Spravochnoe posobie. Pod red V.V. Men'shikova. M: Labora 2008; 156-157.
  2. Cannon C.P., Harrington R.A., James S. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet 2010; 375: 283-293.
  3. The CURRENT-OASIS-7 Investigators Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes. N Engl J Med 2010; 363: 930-942.
  4. Gori A.M., Marcucci R., Migliorini A. et al. Incidence and clinical impact of dual nonresponsiveness to aspirin and clopidogrel in patients with drug-eluting stents. J Am Coll Cardiol 2008; 52: 9: 734-739.
  5. Gurbel P.A., Bliden K.P., Samara W. et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis. J Am Coll Cardiol 2005; 46: 1827-1832.
  6. Montalescot G., Wiviott S.D., Braunwald E. et al. for the TRITON-TIMI 38 investigators. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial. Lancet 2009; 373: 723-731.
  7. Sibbing D., Braun S., Morath T. et al. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol 2009; 53: 10: 849-856.

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