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Miklishanskaya S.V.

Russian Medical Academy of Continuous Professional Education

Mazur N.A.

Russian Medical Academy of Continuous Professional Education

Chigineva V.V.

Russian Medical Academy of Continuous Professional Education

Visceral obesity is a reversible factor in pathogenesis of major cardiovascular diseases

Authors:

Miklishanskaya S.V., Mazur N.A., Chigineva V.V.

More about the authors

Journal: Russian Cardiology Bulletin. 2025;20(3): 11‑16

Read: 372 times


To cite this article:

Miklishanskaya SV, Mazur NA, Chigineva VV. Visceral obesity is a reversible factor in pathogenesis of major cardiovascular diseases. Russian Cardiology Bulletin. 2025;20(3):11‑16. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20252003111

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References:

  1. Engin A. The Definition and Prevalence of Obesity and Metabolic Syndrome: Correlative Clinical Evaluation Based on Phenotypes. Adv Exp Med Biol. 2024;1460:1-25.  https://doi.org/10.1007/978-3-031-63657-8_1
  2. Sattar N, Neeland IJ, McGuire DK. Obesity and Cardiovascular Disease: A New Dawn. Circulation. 2024;149:1621-1623. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
  3. Ostrominski JW, Powell-Wiley TM. Risk Stratification and Treatment of Obesity for Primary and Secondary Prevention of Cardiovascular Disease. Curr Atheroscler Rep. 2024;26:11-23.  https://doi.org/10.1007/s11883-023-01182-3
  4. Chumakova GA, Kuznetsova TYu, Druzhilov MA, Gritsenko OV. Metabolic health of the population: a modern view of the problem and solutions. Russian Journal of Cardiology. 2024;29:5896. (In Russ.). https://doi.org/10.15829/1560-4071-2024-5896
  5. Neeland IJ, Ross R, Després JP, et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol. 2019;7:715-25.  https://doi.org/10.1016/S2213-8587(19)30084-1
  6. Druzhilov MA, Druzhilova OYu, Beteleva YuE, Kuznetsova TYu. Obesity as cardiovascular risk factor: accent on quality and functional activity of adipose tissue. Russian Journal of Cardiology. 2015;4:111-117. (In Russ.). https://doi.org/10.15829/1560-4071-2015-04-111-117
  7. Neeland I, Poirier P, Després J. Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management. Circulation. 2018;137:1391-1406. https://doi.org/10.1161/CIRCULATIONAHA.117.029617
  8. Powell-Wiley TM, Poirier P, Burke LE, et al. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;143:e984-e1010. https://doi.org/10.1161/CIR.0000000000000973
  9. Kang PS, Neeland IJ. Body Fat Distribution, Diabetes Mellitus, and Cardiovascular Disease: an Update. Curr Cardiol Rep. 2023;25:1555-1564. https://doi.org/10.1007/s11886-023-01969-5
  10. Iacobellis G. Epicardial fat links obesity to cardiovascular diseases. Prog Cardiovasc Dis. 2023;78:27-33.  https://doi.org/10.1016/j.pcad.2023.04.006
  11. Miklishanskaya SV, Mazur NA. Types of obesity and their impact on long-term outcomes in patients with cardiovascular disease. Obesity and metabolism. 2021;18:125-131. (In Russ.). https://doi.org/10.14341/omet12367
  12. Cuthbertson DJ, Steele T, Wilding JP, et al. What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications? Int J Obes (Lond). 2017;41:853-865.  https://doi.org/10.1038/ijo.2017.4
  13. Taylor R, Holman R. Normal weight individuals who develop type 2 diabetes: the personal fat threshold. ClinSci (Lond). 2015;128:405-410.  https://doi.org/10.1042/CS20140553
  14. Sawami K, Tanaka A, Node K. Anti-obesity therapy for cardiovascular disease prevention: potential expected roles of glucagon-like peptide-1 receptor agonists. Cardiovasc Diabetol. 2022;21:176.  https://doi.org/10.1186/s12933-022-01611
  15. Neeland IJ, Lim S, Tchernof A, et al. Metabolic syndrome. Nat Rev Dis Primers. 2024;10:77.  https://doi.org/10.1038/s41572-024-00563-5
  16. Dhana K, Koolhaas CM, van Rossum EF, et al. Metabolically Healthy Obesity and the Risk of Cardiovascular Disease in the Elderly Population. PLoS ONE. 2016;11:e0154273. https://doi.org/10.1371/journal.pone.0154273
  17. Braescu L, Gaspar M, Buriman D, et al. The Role and Implications of Epicardial Fat in Coronary Atherosclerotic Disease. J Clin Med. 2022;11:4718. https://doi.org/10.3390/jcm11164718
  18. Tchernof A, Després J. Pathophysiology of Human Visceral Obesity: An Update. Physiol Rev. 2013;93:359-404.  https://doi.org/10.1152/physrev.00033.2011
  19. Ilyushenkova J, Sazonova S, Popov E, et al. Radiomic phenotype of epicardial adipose tissue in the prognosis of atrial fibrillation recurrence after catheter ablation in patients with lone atrial fibrillation. J Arrhythm. 2022;38:682-693.  https://doi.org/10.1002/joa3.12760
  20. Krishnan A, Chilton E, Raman J, et al. Are Interactions between Epicardial Adipose Tissue, Cardiac Fibroblasts and Cardiac Myocytes Instrumental in Atrial Fibrosis and Atrial Fibrillation? Cells. 2021;10:2501. https://doi.org/10.3390/cells10092501
  21. Iacobellis G. Epicardial adipose tissue in contemporary cardiology. Nat Rev Cardiol. 2022;19:593-606.  https://doi.org/10.1038/s41569-022-00679-9
  22. Conte M, Petraglia L, Cabaro S, et al. Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial Fibrillation. Front Cardiovasc Med. 2022;9:932262. https://doi.org/10.3389/fcvm.2022.932262
  23. Ichikawa R, Daimon M, Miyazaki T, et al. Infuencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2013;12:38.  https://doi.org/10.1186/1475-2840-12-38
  24. AlJaroudi W, Halley C, Houghtaling P, et al. Impact of body mass index on diastolic function in patients with normal left ventricular ejection fraction. Nutrition and Diabetes. 2012;2:e39.  https://doi.org/10.1038/nutd.2012.14
  25. Maisch B, Alter P, Pankuweit S. Diabetic cardiomyopathy — fact or fiction? Herz. 2011;36:102-115.  https://doi.org/10.1007/s00059-011-3429-4
  26. Sun T, Xie J, Zhu L, et al. Left Ventricular Hypertrophy and Asymptomatic Cardiac Function Impairment in Chinese Patients with Simple Obesity using Echocardiography. Obes Facts. 2015;8:210-219.  https://doi.org/10.1159/000435795
  27. Hall ME, Cohen JB, Ard JD, et al. Weight-Loss Strategies for Prevention and Treatment of Hypertension: A Scientific Statement From the American Heart Association. Hypertension. 2021;78:e38-e50.  https://doi.org/10.1161/HYP.0000000000000202
  28. Hiuge-Shimizu A, Kishida K, Funahashi T, et al. Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study). Ann Med. 2012;44:82-92.  https://doi.org/10.3109/07853890.2010.526138
  29. Kokov AN, Brel NK, Masenko VL, et al. Quantative assessment of visceral adipose depot in patients with ischemic heart disease by using of modern tomographic methods. Complex Issues of Cardiovascular Diseases. 2017;3:113-119. (In Russ.). https://doi.org/10.17802/2306-1278-2017-6-3-113-119
  30. Boone SC, van Smeden M, Rosendaal FR, et al. Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue. Am J Epidemiol. 2022;191:886-899.  https://doi.org/10.1093/aje/kwab298
  31. Yi D, Tang X, Xing Z. Visceral and subcutaneous adiposity and cardiovascular disease: Unravelling associations and prognostic value. Diabetes Obes Metab. 2024;26:5819-5826. https://doi.org/10.1111/dom.15953
  32. Berkovitch A, Kivity S, Klempfner R, et al. Body mass index and the risk of new-onset atrial fibrillation in middle-aged adults. Am Heart J. 2016;173:41-48.  https://doi.org/10.1016/j.ahj.2015.11.016
  33. Middeldorp ME, Pathak RK, Meredith M, et al. Prevention and Regressive Effect of Weight-Loss and Risk Factor Modification on Atrial Fibrillation: the REVERSE-AF study. Europace. 2018;20:1929-1935. https://doi.org/10.1093/europace/euy117
  34. Donnellan E, Wazni O, Elshazly M, et al. Impact of Bariatric Surgery on Atrial Fibrillation Type. Circ Arrhythm Electrophysiol. 2020;13:e007626. https://doi.org/10.1161/CIRCEP.119.007626
  35. Rayner J, Peterzan M, Clarke W, et al. Obesity modifies the energetic phenotype of dilated cardiomyopathy. European Heart Journal. 2021;43(9):868-877.  https://doi.org/10.1093/eurheartj/ehab663
  36. Vest AR, Patel P, Schauer PR, et al. Clinical and Echocardiographic Outcomes After Bariatric Surgery in Obese Patients With Left Ventricular Systolic Dysfunction. Circ Heart Fail. 2016;9:e002260. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002260
  37. Rider OJ, Lewis AJ, Neubauer S. Structural and Metabolic Effects of Obesity on the Myocardium and the Aorta. Obes Facts. 2014;7:329-338.  https://doi.org/10.1159/000368429
  38. Shah RV, Murthy VL, Abbasi SA, et al. Weight loss and progressive left ventricular remodelling: The Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Prev Cardiol. 2015;22:1408-1418. https://doi.org/10.1177/2047487314541731
  39. Kaier TE, Morgan D, Grapsa J, et al. Ventricular remodelling post-bariatric surgery: is the type of surgery relevant? A prospective study with 3D speckle tracking. Eur Heart J Cardiovasc Imaging. 2014;15:1256-1262. https://doi.org/10.1093/ehjci/jeu116
  40. Omura-Ohata Y, Son C, Makino H, et al. Efficacy of visceral fat estimation by dual bioelectrical impedance analysis in detecting cardiovascular risk factors in patients with type 2 diabetes. Cardiovasc Diabetol. 2019;18:137.  https://doi.org/10.1186/s12933-019-0941-y
  41. Gómez-Ambrosi J, González-Crespo I, Catalán V, et al. Clinical usefulness of abdominal bioimpedance (ViScan) in the determination of visceral fat and its application in the diagnosis and management of obesity and its comorbidities. Clin Nutr. 2018;37:580-589.  https://doi.org/10.1016/j.clnu.2017.01.010
  42. Okorokov PL, Vasyukova OV, Vorontsov AV. The methods for the characteristic of adipose tissue in the organism and their clinical significance. Problems of Endocrinology. 2014;60:53-58. (In Russ.). https://doi.org/10.14341/probl201460353-58
  43. Miklishanskaya SV, Zolozova EA, Safiullina AA, Mazur NA. Visceral obesity in patients with different body mass indices. Lechaschy Vrach. 2020;8:66-70. (In Russ.). https://doi.org/10.26295/OS.2020.19.39.011
  44. Mulasi U, Kuchnia AJ, Cole AJ, Earthman CP. Bioimpedance at the Bedside: Current Applications, Limitations, and Opportunities. Nutrition in Clinical Practice. 2015;30(2):180-193.  https://doi.org/10.1177/0884533614568155
  45. Omura-Ohata Y, Son C, Makino H, et al. Efficacy of visceral fat estimation by dual bioelectrical impedance analysis in detecting cardiovascular risk factors in patients with type 2 diabetes. Cardiovasc Diabetol. 2019;18:137.  https://doi.org/10.1186/s12933-019-0941-y
  46. Yamakage H, Ito R, Tochiya M, et al. The utility of dual bioelectrical impedance analysis in detecting intra-abdominal fat area in obese patients during weight reduction therapy in comparison with waist circumference and abdominal CT. Endocrine Journal. 2014;61(8):807-819.  https://doi.org/10.1507/endocrj.EJ14-0092
  47. Berker D, Koparal S, Işik S, et al. Compatibility of different methods for the measurement of visceral fat in different body mass index strata. Diagn Interv Radiol. 2010;16:99-105.  https://doi.org/10.4261/1305-3825.DIR.2749-09.1
  48. Park KS, Lee DH, Lee J, et al. Comparison Between Two Methods of Bioelectrical Impedance Analyses for Accuracy in Measuring Abdominal Visceral Fat Area. J Diabetes Complications. 2016;30:343-349.  https://doi.org/10.1016/j.jdiacomp.2015.10.014
  49. Gómez-Ambrosi J, González-Crespo I, Catalán V, et al. Clinical usefulness of abdominal bioimpedance (ViScan) in the determination of visceral fat and its application in the diagnosis and management of obesity and its comorbidities. Clin Nutr. 2018;37:580-589.  https://doi.org/10.1016/j.clnu.2017.01.010
  50. Lee DH, Park KS, Ahn S, et al. Comparison of Abdominal Visceral Adipose Tissue Area Measured by Computed Tomography with That Estimated by Bioelectrical Impedance Analysis Method in Korean Subjects. Nutrients. 2015;7:10513-10524. https://doi.org/10.3390/nu7125548
  51. Browning LM, Mugridge O, Chatfield MD, et al. Validity of a new abdominal bioelectrical impedance device to measure abdominal and visceral fat: comparison with MRI. Obesity. 2010;18:2385-2391. https://doi.org/10.1038/oby.2010.71
  52. Lee JK, Park YS, Kim K, et al. Comparison of Bioelectrical Impedance Analysis and Computed Tomography on Body Composition Changes Including Visceral Fat After Bariatric Surgery in Asian Patients with Obesity. Obes Surg. 2021;31:4243-4250. https://doi.org/10.1007/s11695-021-05569-6
  53. Murphy J, Bacon SL, Morais JA, et al. Intra-Abdominal Adipose Tissue Quantification by Alternative Versus Reference Methods: A Systematic Review and Meta-Analysis. Obesity. 2019;27:1115-1122. https://doi.org/10.1002/oby.22494
  54. Miklishanskaya SV, Zolozova EA, Orlovsky AA, et al. Justification of the need to create a new classification of obesity. Lechaschy Vrach. 2021;7:58-62. (In Russ.). https://doi.org/10.51793/OS.2021.24.7.011
  55. Miklishanskaya SV, Mazur NA. Rational approaches to the treatment of patients with overweight and obesity: a cardiologist’s view. Rational Pharmacotherapy in Cardiology. 2024;20:652-659. (In Russ.). https://doi.org/10.20996/1819-6446-2024-3087

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