The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Alekyan B.G.

Vishnevsky National Medical Research Center for Surgery;
Russian Medical Academy of Continuous Professional Education

Meleshenko N.N.

Vishnevsky National Medical Research Center for Surgery

Novak A.Ya.

Vishnevsky National Medical Research Center for Surgery

Kuropii T.S.

Vishnevsky National Medical Research Center for Surgery

Invasive physiology and intravascular imaging in patients with three-vessel coronary artery disease

Authors:

Alekyan B.G., Meleshenko N.N., Novak A.Ya., Kuropii T.S.

More about the authors

Journal: Russian Cardiology Bulletin. 2025;20(3): 5‑10

DOI: 10.17116/Cardiobulletin2025200315

Read: 269 times

Download PDF (RU)
Contact the author
Table of contents

INVASIVE PHYSIOLOGY AND INTRAVASCULAR IMAGING IN PATIENTS WITH THREE-VESSEL CORONARY ARTERY DISEASE
INVASIVE PHYSIOLOGY AND INTRAVASCULAR IMAGING IN PATIENTS WITH THREE-VESSEL CORONARY ARTERY DISEASE

To cite this article:

Alekyan BG, Meleshenko NN, Novak AYa, Kuropii TS. Invasive physiology and intravascular imaging in patients with three-vessel coronary artery disease. Russian Cardiology Bulletin. 2025;20(3):5‑10. (In Russ.)
https://doi.org/10.17116/Cardiobulletin2025200315

 
ЭндоКард
Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Prediction of myocardial contractility after coro­nary bypass surgery acco­rding to preoperative contrast-enhanced cardiac magnetic reso­nance imaging and echo­cardiography data. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(5):506-511
Prognostic role of frailty in early and long-term prognosis after coro­nary artery bypass grafting. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(5):512-518
Cyto­kine profile in middle-aged men with acute and chro­nic coro­nary syndrome and its rela­tion with coro­nary bed lesion seve­rity. Russian Journal of Preventive Medi­cine. 2024;(10):101-107
Reha­bilitation pote­ntial of patients with ischemic heart disease who unde­rwent auto­venous coro­nary artery bypass surgery in the evaluation of reha­bilitation treatment effe­ctiveness. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(5):29-39
Inde­pendent adve­rse outcomes predictors in patients with stable coro­nary heart disease after sche­duled percutaneous coro­nary inte­rventions. Russian Journal of Preventive Medi­cine. 2024;(11):94-101
Improving an auto­matic stress test analysis protocol as a problem solu­tion for sympatho-dependent arrhythmias identification. Russian Journal of Preventive Medi­cine. 2024;(11):115-121
Cost-effectiveness of using rubi­dium-82 chlo­ride perfusion PET for planning myocardial reva­scularization procedures. Piro­gov Russian Journal of Surgery. 2024;(12-2):58-65
Mode­rate ischemic mitral insu­fficiency with severe left ventricular dysfunction: surgical treatment depe­nding on predictors of adve­rse long-term outcomes. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;(6):651-659
Radionuclide methods in analysis of myocardial perfusion and meta­bolic acti­vity. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(4):12-19
Reclassification of ischemic heart disease epidemiological criteria. Russian Journal of Preventive Medi­cine. 2024;(12):61-68
Abstract:

Three-vessel coronary artery disease (CAD) is common in clinical practice and associated with high incidence of complications and mortality. Optimal myocardial revascularization strategy in this group of patients is still a matter of debates despite large scientific data. This review evaluates current approaches for myocardial revascularization in patients with three-vessel CAD based on newly published literature data. We describe invasive physiology (fractional flow reserve, instantaneous wave-free ratio), intravascular ultrasound and combination of these modalities in patients with three-vessel CAD.

Keywords:

coronary artery disease
three-vessel coronary artery disease
fractional flow reserve
instantaneous wave-free ratio
intravascular ultrasound
myocardial revascularization strategy

Authors:

Alekyan B.G.

Vishnevsky National Medical Research Center for Surgery;
Russian Medical Academy of Continuous Professional Education

Meleshenko N.N.

Vishnevsky National Medical Research Center for Surgery

Novak A.Ya.

Vishnevsky National Medical Research Center for Surgery

Kuropii T.S.

Vishnevsky National Medical Research Center for Surgery

Received:

28.04.2025

Accepted:

08.06.2025

Close metadata

References:

  1. World Health Organization Global Health Estimates 2018: Disease Burden by Cause, Sex, by Country and Region, 2000—2016 World Health Organization. 2018.
  2. Norhammar A, Malmberg K, Diderholm E, et al. Diabetes mellitus: the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization. J Am Coll Cardiol. 2004;43(4):585-591.  https://doi.org/10.1016/j.jacc.2003.08.050
  3. Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC Guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415-3537. https://doi.org/10.1093/eurheartj/ehae177
  4. Park SJ, Ahn JM, Kim YH, et al. Trial of everolimus-eluting stents or bypass surgery for coronary disease. N Engl J Med. 2015;372(13):1204-1212. https://doi.org/10.1056/NEJMoa1415447
  5. Thuijs DJFM, Kappetein AP, Serruys PW, et al. Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial. Lancet. 2019;394(10206):1325-1334. https://doi.org/10.1016/S0140-6736(19)31997-X
  6. Farkouh ME, Domanski M, Sleeper LA, et al. Strategies for multivessel revascularization in patients with diabetes. N Engl J Med. 2012;367(25):2375-2384. https://doi.org/10.1056/NEJMoa1211585
  7. Rathod KS, Koganti S, Jain AK, et al. Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes. J Am CollCardiol. 2018;72(17):1989-1999. https://doi.org/10.1016/j.jacc.2018.07.089
  8. Emond M, Mock MB, Davis KB, et al. Long-term survival of medically treated patients in the Coronary Artery Surgery Study (CASS) Registry. Circulation. 1994;90(6):2645-2657. https://doi.org/10.1161/01.cir.90.6.2645
  9. Zimarino M, Ricci F, Romanello M, et al. Complete myocardial revascularization confersalarger clinical benefit when performed with state-of-the-art techniques in high-risk patients with multivessel coronary artery disease: a meta-analysis of randomized and observational studies. Catheter Cardiovasc Interv. 2015;87:3-12. 
  10. Bangalore S, Guo Y, Samadashvili Z, et al. Everolimus-eluting stents or bypass surgery for multivessel coronary disease. N Engl J Med. 2015; 372(13):1213-1222. https://doi.org/10.1056/NEJMoa1412168
  11. Gössl M, Faxon DP, Bell MR, et al. Complete versus incomplete revascularization with coronary artery bypass graft or percutaneous intervention in stable coronary artery disease. Circ Cardiovasc Interv. 2012;5(4):597-604.  https://doi.org/10.1161/CIRCINTERVENTIONS.111.965509
  12. Gallinoro E, Paolisso P, Di Gioia G, et al. Deferral of Coronary Revascularization in Patients With Reduced Ejection Fraction Based on Physiological Assessment: Impact on Long-Term Survival. J Am Heart Assoc. 2022;11(19):e026656. https://doi.org/10.1161/JAHA.122.026656
  13. Head SJ, Mack MJ, Holmes DR Jr, et al. Incidence, predictors and outcomes of incomplete revascularization after percutaneous coronary intervention and coronary artery bypass grafting: a subgroup analysis of 3-year SYNTAX data. Eur J Cardiothorac Surg. 2012;41(3):535-541.  https://doi.org/10.1093/ejcts/ezr105
  14. Garcia S, Sandoval Y, Roukoz H, et al. Outcomes after complete versus incomplete revascularization of patients with multivessel coronary artery disease: a meta-analysis of 89,883 patients enrolled in randomized clinical trials and observational studies. J Am Coll Cardiol. 2013;62(16):1421-1431. https://doi.org/10.1016/j.jacc.2013.05.033
  15. Ahn JM, Yoon SH, Roh JH, et al. Trends in Outcomes of Revascularization for Left Main Coronary Disease or Three-Vessel Disease With the Routine Incorporation of Fractional Flow Reserve in Real Practice. Am J Cardiol. 2015;116(8):1163-1171. https://doi.org/10.1016/j.amjcard.2015.07.028
  16. VanBelle E, Gil R, Klauss V, et al. Impact of routine invasive physiology at time of angiography in patients with multivessel coronary artery disease on reclassification of revascularization strategy: results from the DEFINE REAL Study. JACC Cardiovasc Interv. 2018;11(4):354-365.  https://doi.org/10.1016/j.jcin.2017.11.030
  17. Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360(3):213-224.  https://doi.org/10.1056/NEJMoa0807611
  18. Zimmermann FM, Ding VY, Pijls NHJ, et al. Fractional Flow Reserve-Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial. Circulation. 2023;148(12):950-958.  https://doi.org/10.1161/CIRCULATIONAHA.123.065770
  19. Fearon WF, Zimmermann FM, DeBruyne B, et al. Fractional Flow Reserve-Guided PCI as Compared with Coronary Bypass Surgery. N Engl J Med. 2022;386(2):128-137.  https://doi.org/10.1056/NEJMoa2112299
  20. Götberg M, Cook CM, Sen S, et al. The Evolving Future of Instantaneous Wave-Free Ratio and Fractional Flow Reserve. J Am Coll Cardiol. 2017;70(11):1379-1402. https://doi.org/10.1016/j.jacc.2017.07.770
  21. Maini R, Moscona J, Katigbak P, et al. Instantaneous wave-free ratio as an alternative to fractional flow reserve in assessment of moderate coronary stenoses: A meta-analysis of diagnostic accuracy studies. Cardiovasc Revasc Med. 2018;19(5 PtB):613-620.  https://doi.org/10.1016/j.carrev.2017.12.014
  22. Petraco R, Escaned J, Sen S, et al. Classification performance of instantaneous wave-free ratio (iFR) and fractional flow reserve in a clinical population of intermediate coronary stenoses: results of the ADVISE registry. Euro Intervention. 2013;9(1):91-101.  https://doi.org/10.4244/EIJV9I1A14
  23. Davies JE, Sen S, Dehbi HM, et al. Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI. N Engl J Med. 2017;376(19):1824-1834. https://doi.org/10.1056/NEJMoa1700445
  24. Götberg M, Christiansen EH, Gudmundsdottir IJ, et al. Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI. N Engl J Med. 2017;376(19):1813-1823. https://doi.org/10.1056/NEJMoa1616540
  25. Alekyan B.G., Karapetyan N.G., Meleshenko N.N., Revishvili A.Sh. Results of myocardial revascularization in patients with coronary artery disease with intermediate coronary stenosis under control of instantaneous wave-free ratio. Russian Journal of Endovascular Surgery. 2021;8(1):20-6.  https://doi.org/10.24183/2409-4080-2021-8-1-20-26
  26. Alekyan B.G., Meleshenko N.N., Atroshenko V.V., Navaliev Yu.M. Long-term results of treatment of patients with coronary disease and multivessel coronary artery lesion under the control of instantaneous wave-free ratio. Russian Journal of Endovascular Surgery. 2024; 11 (4): 422-434.  https://doi.org/:10.24183/2409-4080-2024-11-4-422-434
  27. Svanerud J, Ahn J M, Jeremias A, et al. Validation of a novel non-hyperaemic index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study. EuroIntervention. 2018;14(7):806-814.  https://doi.org/10.4244/EIJ-D-18-00342
  28. Van’t Veer M, Pijls NHJ, Hennigan B, et al. Comparison of Different Diastolic Resting Indexes to iFR: Are They All Equal? Jam Col lCardiol. 2017;70(25):3088-3096. https://doi.org/10.1016/j.jacc.2017.10.066
  29. Hong SJ, Mintz GS, Ahn CM, et al. Effect of Intravascular Ultrasound-Guided Drug-Eluting Stent Implantation: 5-Year Follow-Up of the IVUS-XPL Randomized Trial. JACC Cardiovasc Interv. 2020;13(1):62-71.  https://doi.org/10.1016/j.jcin.2019.09.033
  30. Gao XF, Ge Z, Kong XQ, et al. 3-Year Outcomesofthe ULTIMATE Trial Comparing Intravascular Ultrasound Versus Angiography-Guided Drug Eluting Stent Implantation. JACC Cardiovasc Interv. 2021;14(3):247-257.  https://doi.org/10.1016/j.jcin.2020.10.001
  31. Lee JM, Choi KH, Song YB, et al. Intravascular Imaging-Guided or Angiography-Guided Complex PCI. N Engl J Med. 2023;388(18):1668-1679. https://doi.org/10.1056/NEJMoa2216607
  32. Lawton JS, Tamis-Holland JE, Bangalore S, et al. 2021 ACC/AHA/SCAI Guideline for Coronary Artery Revascularization: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022; 145(3):e4-e17.  https://doi.org/10.1161/CIR.0000000000001039
  33. Matsumura-Nakano Y, Shiomi H, Morimoto T, et al. Comparison of Outcomes of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting Among Patients With Three-Vessel Coronary Artery Disease in the New-Generation Drug-Eluting Stents Era (From CREDO-Kyoto PCI/CABG Registry Cohort-3). Am J Cardiol. 2021;145:25-36. 
  34. Yamamoto K, Shiomi H, Morimoto T, et al. Optimal Intravascular Ultrasound-Guided Percutaneous Coronary Intervention in Patients With Multivessel Disease. JACCAsia. 2023;3(2):211-225. Published 2023 Mar 11.  https://doi.org/10.1016/j.jacasi.2022.12.009
  35. Zhang D, Liu X, Xia J, et al. A physics-guided deep learning approach for functional assessment of cardiovascular disease in iot-based smart health.. IEEE Internet of Things Journal. PP(99): 1-1.  https://doi.org/10.1109/JIOT.2023.3240536
  36. Iannaccone M, Abdirashid M, Annone U, et al. Comparison between functional and intravascular imaging approaches guiding percutaneous coronary intervention: A network meta-analysis of randomized and propensity matching studies. Catheter Cardiovasc Interv. 2020;95(7):1259-1266. https://doi.org/10.1002/ccd.28410
  37. Koo BK, Hu X, Kang J, et al. Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI. N Engl J Med. 2022;387(9):779-789.  https://doi.org/10.1056/NEJMoa2201546
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.