Heart failure with preserved ejection fraction: morphofunctional state of the heart throughout 2 years after COVID-19 pneumonia

Shirokov N.E.; Yaroslavskaya E.I.; Krinochkin D.V.; Musikhina N.A.; Petelina T.I.

doi:https://doi.org/10.17116/Cardiobulletin20241903153

Shirokov N.E.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0002-4325-2633

Yaroslavskaya E.I.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0003-1436-8853

Krinochkin D.V.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0003-4993-056X

Musikhina N.A.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0002-8280-2028

Petelina T.I.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0001-6251-4179

Heart failure with preserved ejection fraction: morphofunctional state of the heart throughout 2 years after COVID-19 pneumonia

Authors:

Shirokov N.E., Yaroslavskaya E.I., Krinochkin D.V., Musikhina N.A., Petelina T.I.

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Journal: Russian Cardiology Bulletin. 2024;19(3): 53‑61

DOI: 10.17116/Cardiobulletin20241903153

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To cite this article:

Shirokov NE, Yaroslavskaya EI, Krinochkin DV, Musikhina NA, Petelina TI. Heart failure with preserved ejection fraction: morphofunctional state of the heart throughout 2 years after COVID-19 pneumonia. Russian Cardiology Bulletin. 2024;19(3):53‑61. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20241903153

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)

Использование инфографики авторами научных работ

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OBJECTIVE

To analyze morphofunctional state of the heart according to echocardiography data depending on heart failure with preserved ejection fraction (HFpEF) throughout 2 years after COVID-19 pneumonia.

MATERIAL AND METHODS

Among 380 patients in the Prospective Registry of Persons with COVID-19-Associated Pneumonia, we selected 95 patients in 3 months after COVID-19 pneumonia for diastolic stress test (DST) and instrumental confirmation of HFpEF according to the HFA-PEFF diagnostic algorithm. Mean comprised 42%. Mean age was 57.5±7.1 years. Patients with negative DST (at visit 2 — 2 years later) made up the 1^st group (n=77), patients with positive DST — the 2^nd group (n=18). We analyzed left and right ventricular longitudinal strain (LS).

RESULTS

Both groups were comparable in main clinical and functional parameters 3 months after COVID-19 pneumonia, with the exception of NYHA class of heart failure (1.3±0.5 and 1.6±0.7, respectively, p=0.035) and HFA-PEFF algorithm scores (2.8±0.9 and 3.6±1.2, respectively, p=0.004). There were differences in left atrial reservoir strain (LASr) at visit 1 (29.6% [26.8;33.4] and 25.6% [20.0;28.4], p=0.002) and visit 2 (30.1% [27.8;36.7] and 23.8% [20.0;28.8], p<0.001). There was increase of left ventricular annular velocity assessed by tissue Doppler imaging (9.0 [7.5; 10.5] cm/s at visit 1 and 10.0 [8.0; 11.0] cm/s at visit 2, p=0.001), basal (17.5±2.6 and 19.0±2.4%, respectively, p<0.001) and mid-ventricular longitudinal strain (19.0±2.1 and 19.8±2.2%, p=0.016) only in the 1^st group. According to logistic regression, the complex of LASr (OR 0.848; 95% CI: 0.738—0.975; p=0.020) and TDI e’ lat (OR 0.666; 95% CI: 0.451—0.982; p=0.040) at visit 2 were independently associated with positive DST. In ROC analysis, sensitivity and specificity of left atrial stiffness index (LASI) with cutoff value 0.33 in predicting positive DST were 72.2 and 81.8%, respectively (AUC=0.820; p<0.001).

CONCLUSION

In 2 years after COVID-19 pneumonia, contractile and diastolic functions recovered in patients without HFpEF.

Keywords:

COVID-19

heart failure with preserved ejection fraction

longitudinal strain

left atrial reservoir phase

immune inflammation

Authors:

Shirokov N.E.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0002-4325-2633

Yaroslavskaya E.I.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0003-1436-8853

Krinochkin D.V.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0003-4993-056X

Musikhina N.A.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0002-8280-2028

Petelina T.I.

Tyumen cardiology research center — Tomsk national research medical center

ORCID: 0000-0001-6251-4179

Received:

05.10.2023

Accepted:

02.11.2023

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