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Mironova A.I.

National Medical Research Center of Cardiology

Kropacheva E.S.

National Medical Research Center of Cardiology

Komlev A.E.

Chazov National Research Center of Cardiology

Makeev M.I.

National Medical Research Center of Cardiology

Imaev T.E.

Chazov National Research Center of Cardiology

Panchenko E.P.

National Medical Research Center of Cardiology

Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation

Authors:

Mironova A.I., Kropacheva E.S., Komlev A.E., Makeev M.I., Imaev T.E., Panchenko E.P.

More about the authors

Journal: Russian Cardiology Bulletin. 2021;16(3): 7‑14

Read: 3539 times


To cite this article:

Mironova AI, Kropacheva ES, Komlev AE, Makeev MI, Imaev TE, Panchenko EP. Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation. Russian Cardiology Bulletin. 2021;16(3):7‑14. (In Russ.)
https://doi.org/10.17116/Cardiobulletin2021160317

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References:

  1. Varadarajan P, Kapoor N, Bansal RC, Pai RG. Clinical profile and natural history of 453 nonsurgically managed patients with severe aortic stenosis. The Annals of Thoracic Surgery. 2006;82(6):2111-2115. https://doi.org/10.1016/j.athoracsur.2006.07.048
  2. Iung B, Cachier A, Baron G, Messika-Zeitoun D, Delahaye F, Tornos P, Gohlke-Bärwolf C, Boersma E, Ravaud P, Vahanian A. Decision-making in elderly patients with severe aortic stenosis: why are so many denied surgery? European Heart Journal. 2005;26(24):2714-2720. https://doi.org/10.1093/eurheartj/ehi471
  3. Smith CR, Leon MB, Mack MJ, Miller DC, Moses JW, Svensson LG, Tuzcu EM, Webb JG, Fontana GP, Makkar RR, Williams M, Dewey T, Kapadia S, Babaliaros V, Thourani VH, Corso P, Pichard AD, Bavaria JE, Herrmann HC, Akin JJ, Anderson WN, Wang D, Pocock SJ; PARTNER Trial Investigators. Transcatheter versus surgical aortic-valve replacement in high-risk patients. New England Journal of Medicine. 2011;364(23):2187-2198. https://doi.org/10.1056/NEJMoa1103510
  4. Gilard M, Eltchaninoff H, Iung B, Donzeau-Gouge P, Chevreul K, Fajadet J, Leprince P, Leguerrier A, Lievre M, Prat A, Teiger E, Lefevre T, Himbert D, Tchetche D, Carrié D, Albat B, Cribier A, Rioufol G, Sudre A, Blanchard D, Collet F, Dos Santos P, Meneveau N, Tirouvanziam A, Caussin C, Guyon P, Boschat J, Le Breton H, Collart F, Houel R, Delpine S, Souteyrand G, Favereau X, Ohlmann P, Doisy V, Grollier G, Gommeaux A, Claudel JP, Bourlon F, Bertrand B, Van Belle E, Laskar M; FRANCE 2 Investigators. Registry of transcatheter aortic-valve implantation in high-risk patients. New England Journal of Medicine. 2012;366(18):1705-1715. https://doi.org/10.1056/NEJMoa1114705
  5. Rodés-Cabau J, Webb JG, Cheung A, Ye J, Dumont E, Feindel CM, Osten M, Natarajan MK, Velianou JL, Martucci G, DeVarennes B, Chisholm R, Peterson MD, Lichtenstein SV, Nietlispach F, Doyle D, DeLarochellière R, Teoh K, Chu V, Dancea A, Lachapelle K, Cheema A, Latter D, Horlick E. Transcatheter aortic valve implantation for the treatment of severe symptomatic aortic stenosis in patients at very high or prohibitive surgical risk: acute and late outcomes of the multicenter Canadian experience. Journal of the American College of Cardiology. 2010;55(11):1080-1090. https://doi.org/10.1016/j.jacc.2009.12.014
  6. Himbert D, Pontnau F, Messika-Zeitoun D, Descoutures F, Détaint D, Cueff C, Sordi M, Laissy JP, Alkhoder S, Brochet E, Iung B, Depoix JP, Nataf P, Vahanian A. Feasibility and outcomes of transcatheter aortic valve implantation in high-risk patients with stenotic bicuspid aortic valves. American Journal of Cardiology. 2012;110(6):877-883.  https://doi.org/10.1016/j.amjcard.2012.04.064
  7. Rahhab Z, El Faquir N, Tchetche D, Delgado V, Kodali S, Mara Vollema E, Bax J, Leon MB, Van Mieghem NM. Expanding the indications for transcatheter aortic valve implantation. Nature Reviews. Cardiology. 2020;17(2):75-84.  https://doi.org/10.1038/s41569-019-0254-6
  8. Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK, Thourani VH, Tuzcu EM, Miller DC, Herrmann HC, Doshi D, Cohen DJ, Pichard AD, Kapadia S, Dewey T, Babaliaros V, Szeto WY, Williams MR, Kereiakes D, Zajarias A, Greason KL, Whisenant BK, Hodson RW, Moses JW, Trento A, Brown DL, Fearon WF, Pibarot P, Hahn RT, Jaber WA, Anderson WN, Alu MC, Webb JG; PARTNER 2 Investigators. Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients. The New England Journal of Medicin. 2016;374(17):1609-1620. https://doi.org/10.1056/NEJMoa1514616
  9. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Muñoz DR, Rosenhek R, Sjögren J, Mas PT, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL. 2017 ESC/EACTS Guidelines for the Management of Valvular Heart Disease. Revista Espanola de Cardiologia. 2018;71(2):110.  https://doi.org/10.1016/j.rec.2017.12.013
  10. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O’Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients with Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2017;135(25):1159-1195. https://doi.org/10.1161/CIR.0000000000000503
  11. Chakravarty T, Søndergaard L, Friedman J, De Backer O, Berman D, Kofoed KF, Jilaihawi H, Shiota T, Abramowitz Y, Jørgensen TH, Rami T, Israr S, Fontana G, de Knegt M, Fuchs A, Lyden P, Trento A, Bhatt DL, Leon MB, Makkar RR; RESOLVE; SAVORY Investigators. Subclinical leaflet thrombosis in surgical and transcatheter bioprosthetic aortic valves: an observational study. Lancet. 2017;389(10087):2383-2392. https://doi.org/10.1016/S0140-6736(17)30757-2
  12. Hansson NC, Grove EL, Andersen HR, Leipsic J, Mathiassen ON, Jensen JM, Jensen KT, Blanke P, Leetmaa T, Tang M, Krusell LR, Klaaborg KE, Christiansen EH, Terp K, Terkelsen CJ, Poulsen SH, Webb J, Bøtker HE, Nørgaard BL. Transcatheter Aortic Valve Thrombosis: Incidence, Predisposing Factors, and Clinical Implications. Journal of the American College of Cardiology. 2016;68(19):2059-2069. https://doi.org/10.1016/j.jacc.2016.08.010
  13. Holmes DR Jr, Mack MJ, Kaul S, Agnihotri A, Alexander KP, Bailey SR, Calhoon JH, Carabello BA, Desai MY, Edwards FH, Francis GS, Gardner TJ, Kappetein AP, Linderbaum JA, Mukherjee C, Mukherjee D, Otto CM, Ruiz CE, Sacco RL, Smith D, Thomas JD. 2012 ACCF/AATS/SCAI/STS expert consensus document on transcatheter aortic valve replacement. Journal of the American College of Cardiology. 2012;59(13):1200-1254. https://doi.org/10.1016/j.jacc.2012.01.001
  14. Daneault B, Kirtane AJ, Kodali SK, Williams MR, Genereux P, Reiss GR, Smith CR, Moses JW, Leon MB. Stroke associated with surgical and transcatheter treatment of aortic stenosis: a comprehensive review. Journal of the American College of Cardiology. 2011;58(21):2143-2150. https://doi.org/10.1016/j.jacc.2011.08.024
  15. Kodali SK, Williams MR, Smith CR, Svensson LG, Webb JG, Makkar RR, Fontana GP, Dewey TM, Thourani VH, Pichard AD, Fischbein M, Szeto WY, Lim S, Greason KL, Teirstein PS, Malaisrie SC, Douglas PS, Hahn RT, Whisenant B, Zajarias A, Wang D, Akin JJ, Anderson WN, Leon MB; PARTNER Trial Investigators. Two-year outcomes after transcatheter or surgical aortic-valve replacement. The New England Journal of Medicine. 2012;366(18):1686-1695. https://doi.org/10.1056/NEJMoa1200384
  16. Kleiman NS, Maini BJ, Reardon MJ, Conte J, Katz S, Rajagopal V, Kauten J, Hartman A, McKay R, Hagberg R, Huang J, Popma J; CoreValve Investigators. Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors: A Report from the CoreValve Trials. Circulation. Cardiovascular Interventions. 2016;9(9):e003551. https://doi.org/10.1161/CIRCINTERVENTIONS.115.003551
  17. Kapadia S, Agarwal S, Miller DC, Webb JG, Mack M, Ellis S, Herrmann HC, Pichard AD, Tuzcu EM, Svensson LG, Smith CR, Rajeswaran J, Ehrlinger J, Kodali S, Makkar R, Thourani VH, Blackstone EH, Leon MB. Insights into Timing, Risk Factors, and Outcomes of Stroke and Transient Ischemic Attack after Transcatheter Aortic Valve Replacement in the PARTNER Trial (Placement of Aortic Transcatheter Valves). Circulation. Cardiovascular Interventions. 2016;9(9):e002981. https://doi.org/10.1161/CIRCINTERVENTIONS.115.002981
  18. Auffret V, Regueiro A, Del Trigo M, Abdul-Jawad Altisent O, Campelo-Parada F, Chiche O, Puri R, Rodés-Cabau J. Predictors of Early Cerebrovascular Events in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. Journal of the American College of Cardiology. 2016;68(7):673-684.  https://doi.org/10.1016/j.jacc.2016.05.065
  19. Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC); European Association for Cardio-Thoracic Surgery (EACTS), Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schäfers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M. Guidelines on the management of valvular heart disease (version 2012). European Heart Journal. 2012;33(19):2451-2496. https://doi.org/10.1093/eurheartj/ehs109
  20. Stabile E, Pucciarelli A, Cota L, Sorropago G, Tesorio T, Salemme L, Popusoi G, Ambrosini V, Cioppa A, Agrusta M, Catapano D, Moscariello C, Trimarco B, Esposito G, Rubino P. SAT-TAVI (single antiplatelet therapy for TAVI) study: a pilot randomized study comparing double to single antiplatelet therapy for transcatheter aortic valve implantation. International Journal of Cardiology. 2014;174(3):624-627.  https://doi.org/10.1016/j.ijcard.2014.04.170
  21. Rodés-Cabau J, Masson JB, Welsh RC, Garcia Del Blanco B, Pelletier M, Webb JG, Al-Qoofi F, Généreux P, Maluenda G, Thoenes M, Paradis JM, Chamandi C, Serra V, Dumont E, Côté M. Aspirin Versus Aspirin Plus Clopidogrel as Antithrombotic Treatment Following Transcatheter Aortic Valve Replacement With a Balloon-Expandable Valve: The ARTE (Aspirin Versus Aspirin + Clopidogrel Following Transcatheter Aortic Valve Implantation) Randomized Clinical Trial. JACC. Cardiovascular Interventions. 2017;10(13):1357-1365. https://doi.org/10.1016/j.jcin.2017.04.014
  22. Ichibori Y, Mizote I, Maeda K, Onishi T, Ohtani T, Yamaguchi O, Torikai K, Kuratani T, Sawa Y, Nakatani S, Sakata Y. Clinical Outcomes and Bioprosthetic Valve Function After Transcatheter Aortic Valve Implantation Under Dual Antiplatelet Therapy vs. Aspirin Alone. Circulation Journal. 2017;81(3):397-404.  https://doi.org/10.1253/circj.CJ-16-0903
  23. D’Ascenzo F, Verardi R, Visconti M, Conrotto F, Scacciatella P, Dziewierz A, Stefanini GG, Paradis JM, Omedè P, Kodali S, D’Amico M, Rinaldi M, Salizzoni S. Independent impact of extent of coronary artery disease and percutaneous revascularisation on 30-day and one-year mortality after TAVI: a meta-analysis of adjusted observational results. EuroIntervention. 2018;14(11):e1169-e1177. https://doi.org/10.4244/EIJ-D-18-00098
  24. Windecker S, Tijssen J, Giustino G, Guimarães AH, Mehran R, Valgimigli M, Vranckx P, Welsh RC, Baber U, van Es GA, Wildgoose P, Volkl AA, Zazula A, Thomitzek K, Hemmrich M, Dangas GD. Trial design: Rivaroxaban for the prevention of major cardiovascular events after transcatheter aortic valve replacement: Rationale and design of the GALILEO study. American Heart Journal. 2017;184:81-87.  https://doi.org/10.1016/j.ahj.2016.10.017
  25. Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: a randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA. 1999;282(21):2019-2026. https://doi.org/10.1001/jama.282.21.2019
  26. Holy EW, Kebernik J, Allali A, El-Mawardy M, Richardt G, Abdel-Wahab M. Comparison of dual antiplatelet therapy versus oral anticoagulation following transcatheter aortic valve replacement: A retrospective single-center registry analysis. Cardiology Journal. 2017;24(6):649-659.  https://doi.org/10.5603/CJ.a2017.0050
  27. Kappetein AP, Head SJ, Généreux P, Piazza N, van Mieghem NM, Blackstone EH, Brott TG, Cohen DJ, Cutlip DE, van Es GA, Hahn RT, Kirtane AJ, Krucoff MW, Kodali S, Mack MJ, Mehran R, Rodés-Cabau J, Vranckx P, Webb JG, Windecker S, Serruys PW, Leon MB. Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. European Heart Journal. 2012;33(19):2403-2418. https://doi.org/10.1093/eurheartj/ehs255
  28. Brouwer J, Nijenhuis VJ, Delewi R, Hermanides RS, Holvoet W, Dubois CLF, Frambach P, De Bruyne B, van Houwelingen GK, Van Der Heyden JAS, Toušek P, van der Kley F, Buysschaert I, Schotborgh CE, Ferdinande B, van der Harst P, Roosen J, Peper J, Thielen FWF, Veenstra L, Chan Pin Yin DRPP, Swaans MJ, Rensing BJWM, van ‘t Hof AWJ, Timmers L, Kelder JC, Stella PR, Baan J, Ten Berg JM. Aspirin with or without Clopidogrel after Transcatheter Aortic-Valve Implantation. New England Journal of Medicine. 2020;383(15):1447-1457. https://doi.org/10.1056/NEJMoa2017815
  29. Miyasaka Y, Barnes ME, Bailey KR, Cha SS, Gersh BJ, Seward JB, Tsang TS. Mortality trends in patients diagnosed with first atrial fibrillation: a 21-year community-based study. Journal of the American College of Cardiology. 2007;49(9):986-992.  https://doi.org/10.1016/j.jacc.2006.10.062
  30. Sannino A, Gargiulo G, Schiattarella GG, Perrino C, Stabile E, Losi MA, Galderisi M, Izzo R, de Simone G, Trimarco B, Esposito G. A meta-analysis of the impact of pre-existing and new-onset atrial fibrillation on clinical outcomes in patients undergoing transcatheter aortic valve implantation. EuroIntervention. 2016;12(8):1047-1056. https://doi.org/10.4244/EIJY15M11_12
  31. Summers MR, Leon MB, Smith CR, Kodali SK, Thourani VH, Herrmann HC, Makkar RR, Pibarot P, Webb JG, Leipsic J, Alu MC, Crowley A, Hahn RT, Kapadia SR, Tuzcu EM, Svensson L, Cremer PC, Jaber WA. Prosthetic Valve Endocarditis after TAVR and SAVR: Insights from the PARTNER Trials. Circulation. 2019;140(24):1984-1994. https://doi.org/10.1161/CIRCULATIONAHA.119.041399
  32. Abdul-Jawad Altisent O, Durand E, Muñoz-García AJ, Nombela-Franco L, Cheema A, Kefer J, Gutierrez E, Benítez LM, Amat-Santos IJ, Serra V, Eltchaninoff H, Alnasser SM, Elízaga J, Dager A, García Del Blanco B, Ortas-Nadal Mdel R, Marsal JR, Campelo-Parada F, Regueiro A, Del Trigo M, Dumont E, Puri R, Rodés-Cabau J. Warfarin and Antiplatelet Therapy Versus Warfarin Alone for Treating Patients with Atrial Fibrillation Undergoing Transcatheter Aortic Valve Replacement. JACC. Cardiovascular Interventions. 2016;9(16):1706-1717. https://doi.org/10.1016/j.jcin.2016.06.025
  33. Muscente F, De Caterina R. Risk of stroke after transcatheter aortic valve implant: the role of the new oral anticoagulants. European Heart Journal Supplements. 2019;21(suppl B):50-51.  https://doi.org/10.1093/eurheartj/suz016
  34. Panchenko EP, Komarov AL, Kropacheva ES, Dobrovol’skij AB. Protocol for the management of patients who need long-term antithrombotic therapy with invasive interventions. Kardiologicheskij vestnik. 2020;2:63-68. (In Russ.). https://doi.org/10.36396/MS.2020.65.42.009
  35. Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, Boriani G, Castella M, Dan GA, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau JP, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL; ESC Scientific Document Group. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. European Heart Journal. 2021;42(5):373-498.  https://doi.org/10.1093/eurheartj/ehaa612
  36. Garwood CL, Korkis B, Grande D, Hanni C, Morin A, Moser LR. Anticoagulation Bridge Therapy in Patients with Atrial Fibrillation: Recent Updates Providing a Rebalance of Risk and Benefit. Pharmacotherapy. 2017;37(6):712-724.  https://doi.org/10.1002/phar.1937

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