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Baranov A.A.

Meshalkin National Medical Research Center

Badoyan A.G.

Meshalkin National Medical Research Center

Khelimskiy D.A.

Meshalkin National Medical Research Center

Cydenova A.Yu.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Naydenov R.A.

Meshalkin National Medical Research Center

Boboshko V.A.

Meshalkin National Medical Research Center

Lomivorotov V.V.

Meshalkin National Medical Research Center

Belov V.A.

Sukhanov Federal Center of Cardiovascular Surgery

Arutyunyan V.B.

Sukhanov Federal Center of Cardiovascular Surgery

Kadyraliev B.K.

Sukhanov Federal Center of Cardiovascular Surgery

Krestyaninov O.V.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Predictors and impact of myocardial injury (VARC-3 criteria) after transcatheter aortic valve implantation

Authors:

Baranov A.A., Badoyan A.G., Khelimskiy D.A., Cydenova A.Yu., Naydenov R.A., Boboshko V.A., Lomivorotov V.V., Belov V.A., Arutyunyan V.B., Kadyraliev B.K., Krestyaninov O.V.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(5): 489‑498

DOI: 10.17116/kardio202417051489

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To cite this article:

Baranov AA, Badoyan AG, Khelimskiy DA, et al. . Predictors and impact of myocardial injury (VARC-3 criteria) after transcatheter aortic valve implantation. Russian Journal of Cardiology and Cardiovascular Surgery. 2024;17(5):489‑498. (In Russ.)
https://doi.org/10.17116/kardio202417051489

Подписка 2025 (Russian Journal of Cardiology and Cardiovascular Surgery)
 
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OBJECTIVE

To determine the factors associated with periprocedural increase in high-sensitive troponin I (hsTrI) after transcatheter aortic valve implantation (TAVI), as well as to evaluate prognostic significance of periprocedural myocardial injury (PMI) on survival of patients after TAVI.

MATERIAL AND METHODS

A retrospective study included 149 patients who underwent TAVI for severe aortic stenosis. Analysis included patients with available assessment of hsTrI before and after TAVI. According to postoperative hsTrI (VARC-3 criteria), all patients were divided into 2 groups: group 1 — patients with 70 times excess of the upper limit of normal (ULN) hsTrI («hsTrI≥70×ULN»), group 2 — patients with hsTrI <70xULN («hsTrI<70×ULN»).

RESULTS

PMI occurred in 18.8% of patients. According to multivariate regression analysis, independent predictors of 70-fold increase in hsTrI were age (OR 1.13, 95% CI 1.01—1.26, p=0.03), female sex (OR 15.6, 95% CI 2.57—95.20, p=0.003) and bioprosthesis implantation depth (OR 1.46, 95% CI 1.10—1.94, p=0.009). There were no significant differences in survival rate (85.7% vs. 90.9%, plog-rank=0.48).

CONCLUSION

Age, female gender and bioprosthesis implantation depth were independent predictors of PMI after TAVI. Myocardial injury after TAVI does not affect long-term survival of patients.

Keywords:

aortic stenosis
transcatheter aortic valve implantation
troponin
myocardial infarction
myocardial injury

Authors:

Baranov A.A.

Meshalkin National Medical Research Center

Badoyan A.G.

Meshalkin National Medical Research Center

Khelimskiy D.A.

Meshalkin National Medical Research Center

Cydenova A.Yu.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Naydenov R.A.

Meshalkin National Medical Research Center

Boboshko V.A.

Meshalkin National Medical Research Center

Lomivorotov V.V.

Meshalkin National Medical Research Center

Belov V.A.

Sukhanov Federal Center of Cardiovascular Surgery

Arutyunyan V.B.

Sukhanov Federal Center of Cardiovascular Surgery

Kadyraliev B.K.

Sukhanov Federal Center of Cardiovascular Surgery

Krestyaninov O.V.

Meshalkin National Medical Research Center;
Novosibirsk State Medical University

Received:

15.08.2023

Accepted:

28.11.2023

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