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Kudryavtseva A.A.

Sechenov First Moscow State Medical University

Aga A.D.

Sechenov First Moscow State Medical University

Napalkov D.A.

Sechenov First Moscow State Medical University

Zolotukhin I.A.

Pirogov Russian National Research Medical University

Sokolova A.A.

Sechenov First Moscow State Medical University

Venous Thromboembolism in Women with Chronic Venous Disease of the Lower Extremities Receiving Direct Oral Anticoagulants for Atrial Fibrillation

Authors:

Kudryavtseva A.A., Aga A.D., Napalkov D.A., Zolotukhin I.A., Sokolova A.A.

More about the authors

Journal: Journal of Venous Disorders. 2024;18(2): 106‑114

DOI: 10.17116/flebo202418021106

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VENOUS THROMBOEMBOLISM IN WOMEN WITH CHRONIC VENOUS DISEASE OF THE LOWER EXTREMITIES RECEIVING DIRECT ORAL ANTICOAGULANTS FOR ATRIAL FIBRILLATION
VENOUS THROMBOEMBOLISM IN WOMEN WITH CHRONIC VENOUS DISEASE OF THE LOWER EXTREMITIES RECEIVING DIRECT ORAL ANTICOAGULANTS FOR ATRIAL FIBRILLATION

To cite this article:

Kudryavtseva AA, Aga AD, Napalkov DA, Zolotukhin IA, Sokolova AA. Venous Thromboembolism in Women with Chronic Venous Disease of the Lower Extremities Receiving Direct Oral Anticoagulants for Atrial Fibrillation. Journal of Venous Disorders. 2024;18(2):106‑114. (In Russ.)
https://doi.org/10.17116/flebo202418021106

Подписка 2026 Флебология (Journal of Venous Disorders)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Atrial fibrillation (AF) and chronic venous disease of the lower extremities (CVD) are common. Risk factors for both these diseases are often similar. AF and CVD can lead to thromboembolic complications, and anticoagulation is used to prevent these events.

OBJECTIVE

To assess the risk of venous thromboembolism and potential risk factors among women with AF and CVD of the lower extremities receiving direct oral anticoagulants (DOACs).

MATERIAL AND METHODS

A prospective cohort study included 55 women (mean age 71 years). The main group included 28 patients with C2-C6 CVD, the control group — 27 women without CVD or with C0-C1 disease. All patients received DOACs for AF. Incidence of venous thromboembolism was estimated throughout 12-month period.

RESULTS

Venous thrombosis occurred in 3 patients (5.5%). One patient had deep vein thrombosis, 2 patients — superficial vein thrombophlebitis. All cases were registered in the main group (p=0.237). Smoking (p=0.006), obesity (p=0.037), chronic heart failure and hypothyroidism (p=0.048 and p=0.041) were more common in women with thrombotic events. Serum thyroid-stimulating hormone and C-reactive protein were also higher (p=0.008 and p=0.041). Incidence of venous thromboembolic events was higher in patients with chronic venous insufficiency (p=0.002).

CONCLUSION

Women with AF receiving DOACs have a higher risk of venous thromboembolic events in case of concomitant CVD, obesity, hypothyroidism, chronic heart failure, elevated serum CRP and TSH.

Keywords:

chronic venous diseases
atrial fibrillation
deep vein thrombosis
thrombophlebitis
anticoagulation
DOACs

Authors:

Kudryavtseva A.A.

Sechenov First Moscow State Medical University

Aga A.D.

Sechenov First Moscow State Medical University

Napalkov D.A.

Sechenov First Moscow State Medical University

Zolotukhin I.A.

Pirogov Russian National Research Medical University

Sokolova A.A.

Sechenov First Moscow State Medical University

Received:

06.03.2024

Accepted:

11.03.2024

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