Venous Thromboembolism in Women with Chronic Venous Disease of the Lower Extremities Receiving Direct Oral Anticoagulants for Atrial Fibrillation

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OBJECTIVE

To assess the risk of venous thromboembolism and potential risk factors among women with AF and CVD of the lower extremities receiving direct oral anticoagulants (DOACs).

MATERIAL AND METHODS

A prospective cohort study included 55 women (mean age 71 years). The main group included 28 patients with C2-C6 CVD, the control group — 27 women without CVD or with C0-C1 disease. All patients received DOACs for AF. Incidence of venous thromboembolism was estimated throughout 12-month period.

RESULTS

Venous thrombosis occurred in 3 patients (5.5%). One patient had deep vein thrombosis, 2 patients — superficial vein thrombophlebitis. All cases were registered in the main group (p=0.237). Smoking (p=0.006), obesity (p=0.037), chronic heart failure and hypothyroidism (p=0.048 and p=0.041) were more common in women with thrombotic events. Serum thyroid-stimulating hormone and C-reactive protein were also higher (p=0.008 and p=0.041). Incidence of venous thromboembolic events was higher in patients with chronic venous insufficiency (p=0.002).

CONCLUSION

Women with AF receiving DOACs have a higher risk of venous thromboembolic events in case of concomitant CVD, obesity, hypothyroidism, chronic heart failure, elevated serum CRP and TSH.

Keywords:

chronic venous diseases

atrial fibrillation

deep vein thrombosis

thrombophlebitis

anticoagulation

DOACs

Authors:

Kudryavtseva A.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0003-0160-6015

Aga A.D.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-9399-407X

Napalkov D.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0001-6241-2711

Zolotukhin I.A.

Pirogov Russian National Research Medical University

SPIN RSCI: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

Sokolova A.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0001-5938-8917

Received:

06.03.2024

Accepted:

11.03.2024

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