Pharmacological Correction of Venous Reflux before Surgical Treatment of Varicose Veins

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OBJECTIVE

to assess the effectiveness of correction of venous reflux in patients with varicose veins via combination of medical treatment and surgery.

MATERIAL AND METHODS

There were 42 patients with C3-C4 varicose vein disease. All patients were prescribed with micronized purified flavonoid fraction at a daily dose of 1000 mg for one month. After that, stripping or radiofrequency ablation of great saphenous vein was performed in 19 patients. Other 23 patients were included in the control group where only venoactive drug treatment was continued. All patients underwent venous photoplethysmography before and after medical and surgical treatment. We measured venous refilling time (VRT) and ½VRT as indicators of total venous reflux.

RESULTS

Plethysmographic parameters significantly increased after administration of micronized purified flavonoid fraction in both groups. In the main group, VRT increased from 11 (9—16) to 15 (11—20) s, in the control group — from 13 (9.0—16.5) to 15.5 (11.0—19.5) s. VRT significantly increased after surgery up to 27 (15—36) s.

CONCLUSION

Micronized purified flavonoid fraction reduces total venous reflux in patients with C3—C4 varicose veins. Subsequent invasive treatment after prior drug exposure provides a significant improvement in venous return.

Keywords:

varicose veins

venous photoplethysmography

micronized purified flavonoid fraction

venous reflux

venous refilling time

Authors:

Khorev N.G.

Altai State Medical University

ORCID: 0000-0002-2383-4214

Kuznetsova D.V.

Altai State Medical University

ORCID: 0000-0002-9504-4086

Received:

27.12.2022

Accepted:

16.04.2023

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