The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Smetanina M.A.
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
Shadrina A.S.
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia
Zolotukhin I.A.
Pirogov Russian National Research Medical University, Moscow, Russia
Seliverstov E.I.
Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia
Filipenko M.L.
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia
Differentially Expressed Genes in Varicose Veins Disease: Current State of the Problem, Analysis of the Published Data
Journal: Journal of Venous Disorders. 2017;11(4): 190‑204
Views: 3874
Downloaded: 63
To cite this article:
Smetanina MA, Shadrina AS, Zolotukhin IA, Seliverstov EI, Filipenko ML. Differentially Expressed Genes in Varicose Veins Disease: Current State of the Problem, Analysis of the Published Data. Journal of Venous Disorders.
2017;11(4):190‑204. (In Russ.)
https://doi.org/10.17116/flebo2017114190-202
Varicose veins of the lower extremities (VVs) are a common pathology of blood vessels. Molecular mechanisms underlying its development are still not fully understood. One of the approaches to the study of pathogenesis of the diseases is to compare gene expression in normal and pathological conditions, e.g. in normal and varicose veins. In this article, we collected and analyzed the literature data on the differential gene expression in VVs, discussed the methods and approaches used for its investigation, and highlighted problems in this field of research. Three types of studies were analyzed: candidate-gene studies (23 studies), differential displays of mRNA (3), and microarray-based studies (3). We also performed a functional annotation of the genes identified with the microarray technology by means of the Gene Set Enrichment Analysis. This analysis was conducted using the tools of the PANTHER system and the geneXplain platform. The enrichment was calculated for the gene ontologies «biological process», «molecular function», and for Reactome pathways. Many categories that showed statistically significant overrepresentation were related to the organization of cellular and extracellular structures — the cytoskeleton, the extracellular matrix, the interaction of matrix components with cells and between each other, as well as to the response to various organic molecules, including cytokines, and to the hemostatic system.
Keywords:
Authors:
Smetanina M.A.
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
Shadrina A.S.
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia
Zolotukhin I.A.
Pirogov Russian National Research Medical University, Moscow, Russia
Seliverstov E.I.
Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia
Filipenko M.L.
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.