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Pryshchepenko V.A.

Vitebsk State Order of Peoples’ Friendship Medical University

Interleukin-10 levels in patients with alcoholic liver disease

Authors:

Pryshchepenko V.A.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2023;12(1): 29‑36

DOI: 10.17116/dokgastro20231201129

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Table of contents

INTERLEUKIN-10 LEVELS IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
INTERLEUKIN-10 LEVELS IN PATIENTS WITH ALCOHOLIC LIVER DISEASE

To cite this article:

Pryshchepenko VA. Interleukin-10 levels in patients with alcoholic liver disease. Russian Journal of Evidence-Based Gastroenterology. 2023;12(1):29‑36. (In Russ.)
https://doi.org/10.17116/dokgastro20231201129

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To measure interleukin-10 levels in patients with alcoholic liver disease.

MATERIALS AND METHODS

It is a case-control study of diagnostic method. 18 patients with chronic alcoholic hepatitis, 41 patients with alcoholic cirrhosis, and 15 healthy individuals (control group) were included.

RESULTS

IL-10 levels in patients with liver cirrhosis were higher than in the control group (3.15; 0.37—9.2 pg/mml vs. 0; 0—2.7 pg/mml, p=0.01). IL-10 levels did not differ statistically (p>0.05) between patients with chronic hepatitis and the control group, as well as between patients with liver cirrhosis and patients with chronic hepatitis. The level of interleukin-10 was higher in patients with Child-Puge cirrhosis classes B and C (3.15; 1.76—8.24 pg/mml and 6.16; 0.37—12.4 pg/mml, respectively) than in patients with Child-Puge A cirrhosis (0.37; 0—0.83 pg/ml, p<0.05). IL-10 levels were higher in individuals with cirrhosis classes B and C than they were in those with chronic hepatitis and cirrhosis class A (p<0.05). Average strong correlations between the levels of IL-10 and Fib4 (r=0.54), APRI (r=0.58), Forns (r=0.64), hemoglobin (r= –0.63), platelets (r= –0.63), lymphocytes (r= –0.52), segmented neutrophils (r=0.47), PTI (r= –0.59), and APTT (r=0.37) were found in patients with cirrhosis.

CONCLUSION

Interleukin-10 is a crucial anti-inflammatory cytokine involved in the development of alcohol-related liver damage due to inflammation and necrosis inhibition, as well as the promotion of regeneration.

Keywords:

alcoholic liver disease
alcoholic liver cirrhosis
alcoholic hepatitis
inflammation
interleukin-10

Authors:

Pryshchepenko V.A.

Vitebsk State Order of Peoples’ Friendship Medical University

Received:

01.11.2022

Accepted:

18.01.2023

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References:

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