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Fedorin M.M.

Omsk State Medical University

Livzan M.A.

Omsk State Medical University

Gaus O.V.

Omsk State Medical University

IBS in overweight and obese individuals: a new disease phenotype?

Authors:

Fedorin M.M., Livzan M.A., Gaus O.V.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2021;10(2): 52‑60

DOI: 10.17116/dokgastro20211002152

Views: 4358

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To cite this article:

Fedorin MM, Livzan MA, Gaus OV. IBS in overweight and obese individuals: a new disease phenotype?. Russian Journal of Evidence-Based Gastroenterology. 2021;10(2):52‑60. (In Russ.)
https://doi.org/10.17116/dokgastro20211002152

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Irritable bowel syndrome (IBS) occupies the leading position by prevalence among all functional disorders of the digestive tract. IBS acquires new features on a background of excessive body weight and obesity in the time of metabolic syndrome pandemic. This review has been prepared to analyze the features of IBS in overweight and obese individuals. The literature was searched in Embase, PubMed, and Google Scholar using the keywords: irritable bowel syndrome, overweight, obesity, body mass index, visceral fat, mechanisms.

Keywords:

irritable bowel syndrome
obesity
body mass index

Authors:

Fedorin M.M.

Omsk State Medical University

Livzan M.A.

Omsk State Medical University

Gaus O.V.

Omsk State Medical University

Received:

22.02.2021

Accepted:

01.06.2021

List of references:

  1. Chey WD, Kurlander J, Eswaran S. Irritable bowel syndrome: a clinical review. JAMA. 2015;313(9):949-958.  https://doi.org/10.1001/jama.2015.0954
  2. Ivashkin VT, Shelygin YuA, Baranskaya YK, Belousova YA, Beniashvili AG, Vasilyev SV, Golovenko AO, Golovenko OV, Grigoryev YG, Kostenko NV, Lapina TL, Loranskaya ID, Lyashenko OS, Mayev IV, Poluektova YA, Rumyantsev VG, Timerbulatov VM, Trukhmanov AS, Fomenko OYu, Khalif IL, Chashkova EYu, Sheptulin AA, Shifrin OS, Yanovoy VV. Diagnosis and treatment of the irritable bowel syndrome: clinical guidelines of the Russian gastroenterological association and Russian association of coloproctology. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2017;27(5):76-93. (In Russ.).
  3. Aasbrenn M, Høgestøl I, Eribe I, Kristinsson J, Lydersen S, Mala T, Farup PG. Prevalence and predictors of irritable bowel syndrome in patients with morbid obesity: a cross-sectional study. BMC Obesity. 2017;4:22.  https://doi.org/10.1186/s40608-017-0159-z
  4. Aro P, Ronkainen J, Talley NJ, Storskrubb T, Bolling-Sternevald E, Agréus L. Body mass index and chronic unexplained gastrointestinal symptoms: an adult endoscopic population based study. Gut. 2005;54(10):1377-1383. https://doi.org/10.1136/gut.2004.057497
  5. Svedberg P, Johansson S, Wallander MA. Extra-intestinal manifestations associated with irritable bowel syndrome: a twin study. Alimentary pharmacology & Therapeutics. 2002;16(5):975-983.  https://doi.org/10.1046/j.1365-2036.2002.01254.x
  6. Fysekidis M, Bouchoucha M, Bihan H, Reach G, Benamouzig R, Catheline JM. Prevalence and co-occurrence of upper and lower functional gastrointestinal symptoms in patients eligible for bariatric surgery. Obesity Surgery. 2012;22(3):403-410.  https://doi.org/10.1007/s11695-011-0396-z
  7. Schneck AS, Anty R, Tran A, Hastier A, Amor IB, Gugenheim J, Iannelli A, Piche T. Increased Prevalence of Irritable Bowel Syndrome in a Cohort of French Morbidly Obese Patients Candidate for Bariatric Surgery. Obesity Surgery. 2016;26(7):1525-1530. https://doi.org/10.1007/s11695-015-1907-0
  8. Locke GR 3rd, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ. Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities. American Journal of Gastroenterology. 2000;95(1): 157-165.  https://doi.org/10.1111/j.1572-0241.2000.01678.x
  9. Aasbrenn M, Lydersen S, Farup PG. A Conservative Weight Loss Intervention Relieves Bowel Symptoms in Morbidly Obese Subjects with Irritable Bowel Syndrome: A Prospective Cohort Study. Journal of Obesity. 2018;2018:3732753. https://doi.org/10.1155/2018/3732753
  10. Drapkina OM, eds. Brief patient management algorithms at the stage of primary health care. Manual for general practitioners. M.: Vidoks; 2019 (In Russ.).
  11. Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R. Bowel Disorders. Gastroenterology. 2016:S0016-5085(16)00222-5.  https://doi.org/10.1053/j.gastro.2016.02.031
  12. Kibune Nagasako C, Garcia Montes C, Silva Lorena SL, Mesquita MA. Irritable bowel syndrome subtypes: Clinical and psychological features, body mass index and comorbidities. Revista Espanola de Enfermedades Digestivas. 2016;108(2):59-64.  https://doi.org/10.17235/reed.2015.3979/2015
  13. Lee CG, Lee JK, Kang YS, Shin S, Kim JH, Lim YJ, Koh MS, Lee JH, Kang HW. Visceral abdominal obesity is associated with an increased risk of irritable bowel syndrome. American Journal of Gastroenterology. 2015;110(2):310-319.  https://doi.org/10.1038/ajg.2014.422
  14. Emerenziani S, Guarino MPL, Trillo Asensio LM, Altomare A, Ribolsi M, Balestrieri P, Cicala M. Role of Overweight and Obesity in Gastrointestinal Disease. Nutrients. 2019;12(1):111.  https://doi.org/10.3390/nu12010111
  15. El-Salhy M, Gilja OH, Gundersen D, Hatlebakk JG, Hausken T. Endocrine cells in the ileum of patients with irritable bowel syndrome. World Journal of Gastroenterology. 2014;20(9):2383-91.  https://doi.org/10.3748/wjg.v20.i9.2383
  16. Fang XL, Shu G, Yu JJ, Wang LN, Yang J, Zeng QJ, Cheng X, Zhang ZQ, Wang SB, Gao P, Zhu XT, Xi QY, Zhang YL, Jiang QY. The anorexigenic effect of serotonin is mediated by the generation of NADPH oxidase-dependent ROS. PLoS One. 2013;8(1):e53142. https://doi.org/10.1371/journal.pone.0053142
  17. Camilleri M. Serotonergic modulation of visceral sensation: lower gut. Gut. 2002;51(1):i81-6.  https://doi.org/10.1136/gut.51.suppl_1.i81
  18. El-Salhy M, Hatlebakk JG, Hausken T. Possible role of peptide YY (PYY) in the pathophysiology of irritable bowel syndrome (IBS). Neuropeptides. 2020;79:101973. https://doi.org/10.1016/j.npep.2019.101973
  19. Van Der Veek PP, Biemond I, Masclee AA. Proximal and distal gut hormone secretion in irritable bowel syndrome. Scandinavian Journal of Gastroenterology. 2006;41(2):170-177.  https://doi.org/10.1080/00365520500206210
  20. El-Salhy M, Hatlebakk JG, Gilja OH, Hausken T. Densities of rectal peptide YY and somatostatin cells as biomarkers for the diagnosis of irritable bowel syndrome. Peptides. 2015;67:12-19.  https://doi.org/10.1016/j.peptides.2015.02.008
  21. Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. Journal of Physiology. 2009;587(1):19-25.  https://doi.org/10.1113/jphysiol.2008.164269
  22. El-Salhy M, Lillebø E, Reinemo A, Salmelid L. Ghrelin in patients with irritable bowel syndrome. International Journal of Molecular Medicine. 2009;23(6):703-707.  https://doi.org/10.3892/ijmm_00000183
  23. El-Salhy M, Gilja OH, Gundersen D, Hausken T. Endocrine cells in the oxyntic mucosa of the stomach in patients with irritable bowel syndrome. World Journal of Gastrointestinal Endoscopy. 2014;6(5):176-185.  https://doi.org/10.4253/wjge.v6.i5.176
  24. Şahin-Eryılmaz G, Başak K, Çakır-Madenci Ö, Koç H, Tüzün S, Dolapçıoğlu C, Ahıshalı E, Dabak MR. Relationship between irritable bowel syndrome and plasma and tissue ghrelin levels. Turkish Journal of Gastroenterology. 2018;29(6):631-635.  https://doi.org/10.5152/tjg.2018.17593
  25. Hillman JB, Tong J, Tschop M. Ghrelin biology and its role in weight-related disorders. Discovery Medicine. 2011;11(61): 521-528. 
  26. Solomou S, Korbonits M. The role of ghrelin in weight-regulation disorders: implications in clinical practice. Hormones (Athens). 2014;13(4):458-475.  https://doi.org/10.14310/horm.2002.1551
  27. Pulkkinen L, Ukkola O, Kolehmainen M, Uusitupa M. Ghrelin in diabetes and metabolic syndrome. International Journal of Peptides. 2010;2010:248948. https://doi.org/10.1155/2010/248948
  28. Leal Vde O, Mafra D. Adipokines in obesity. Clinica Chimica Acta. 2013;419:87-94.  https://doi.org/10.1016/j.cca.2013.02.003
  29. Semnani S, Roshandel G, Keshtkar A, Najafi L, Amiriani T, Farajollahi M, Moradi A, Joshaghani H. Serum leptin levels and irritable bowel syndrome: a new hypothesis. Journal of Clinical Gastroenterology. 2009;43(9):826-830.  https://doi.org/10.1097/MCG.0b013e3181986900
  30. Russo F, Chimienti G, Clemente C, D’Attoma B, Linsalata M, Orlando A, De Carne M, Cariola F, Semeraro FP, Pepe G, Riezzo G. Adipokine profile in celiac patients: differences in comparison with patients suffering from diarrhea-predominant IBS and healthy subjects. Scandinavian Journal of Gastroenterology. 2013;48(12):1377-1385. https://doi.org/10.3109/00365521.2013.845907
  31. Baram MA, Abbasnezhad A, Ghanadi K, Anbari K, Choghakhori R, Ahmadvand H. Serum Levels of Chemerin, Apelin, and Adiponectin in Relation to Clinical Symptoms, Quality of Life, and Psychological Factors in Irritable Bowel Syndrome. Journal of Clinical Gastroenterology. 2020;54(5):40-49.  https://doi.org/10.1097/MCG.0000000000001227
  32. Katsareli EA, Dedoussis GV. Biomarkers in the field of obesity and its related comorbidities. Expert Opinion on Therapeutic Targets. 2014;18(4):385-401.  https://doi.org/10.1517/14728222.2014.882321
  33. Bashashati M, Rezaei N, Andrews CN, Chen CQ, Daryani NE, Sharkey KA, Storr MA. Cytokines and irritable bowel syndrome: where do we stand? Cytokine. 2012;57(2):201-209.  https://doi.org/10.1016/j.cyto.2011.11.019
  34. Tracey DJ, Walker JS. Pain due to nerve damage: are inflammatory mediators involved? Inflammation Research. 1995;44(10):407-411.  https://doi.org/10.1007/BF01757696
  35. Gaus OV, Livzan MA. Irritable bowel syndrome: what do we know about symptoms today? Consilium Medicum. 2019;21(8):42-48. (In Russ.). https://doi.org/10.26442/20751753.2019.8.190512
  36. Gummesson A, Carlsson LM, Storlien LH, Bäckhed F, Lundin P, Löfgren L, Stenlöf K, Lam YY, Fagerberg B, Carlsson B. Intestinal permeability is associated with visceral adiposity in healthy women. Obesity (Silver Spring). 2011;19(11):2280-2282. https://doi.org/10.1038/oby.2011.251
  37. Bunova SS, Zhernakova NI, Fedorin MM, Skirdenko YP, Osipova OA. Effective antihypertensive therapy: focus on adherence management. Cardiovascular Therapy and Prevention. 2020;19(5): 2663. (In Russ.). https://doi.org/10.15829/1728-8800-2020-2663
  38. Pugliese G, Muscogiuri G, Barrea L, Laudisio D, Savastano S, Colao A. Irritable bowel syndrome: a new therapeutic target when treating obesity? Hormones (Athens). 2019;18(4):395-399.  https://doi.org/10.1007/s42000-019-00113-9
  39. Livzan MA, Osipenko MF. Sindrom perekresta funkcional’nyh zabolevanij pishhevaritel’nogo trakta. Russian Medical Journal. 2012;20(15):768—770. (In Russ.).
  40. Rajilić-Stojanović M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, Tims S, de Vos WM. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology. 2011;141(5):1792-1801. https://doi.org/10.1053/j.gastro.2011.07.043
  41. Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(31):11070-11075. https://doi.org/10.1073/pnas.0504978102
  42. Aasbrenn M, Valeur J, Farup PG. Evaluation of a faecal dysbiosis test for irritable bowel syndrome in subjects with and without obesity. Scandinavian Journal of Clinical and Laboratory Investigation. 2018;78(1-2):109-113.  https://doi.org/10.1080/00365513.2017.1419372
  43. Pickett-Blakely O. Obesity and irritable bowel syndrome: a comprehensive review. Gastroenterology&Hepatology. 2014;10(7):411-416. 
  44. Mathur R, Amichai M, Chua KS, Mirocha J, Barlow GM, Pimentel M. Methane and hydrogen positivity on breath test is associated with greater body mass index and body fat. Journal of Clinical Endocrinology and Metabolism. 2013;98(4):698-702.  https://doi.org/10.1210/jc.2012-3144
  45. Ghoshal UC, Kumar S, Mehrotra M, Lakshmi C, Misra A. Frequency of small intestinal bacterial overgrowth in patients with irritable bowel syndrome and chronic non-specific diarrhea. Journal of Neurogastroenterology and Motility. 2010;16(1):40-46.  https://doi.org/10.5056/jnm.2010.16.1.40
  46. Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutrition. 2014;17(8):1689-1696. https://doi.org/10.1017/S1368980013002115
  47. Salari-Moghaddam A, Keshteli AH, Esmaillzadeh A, Adibi P. Adherence to the pro-inflammatory diet in relation to prevalence of irritable bowel syndrome. Nutrition Journal. 2019;18(1):72.  https://doi.org/10.1186/s12937-019-0487-6
  48. Ramallal R, Toledo E, Martínez JA, Shivappa N, Hébert JR, Martínez-González MA, Ruiz-Canela M. Inflammatory potential of diet, weight gain, and incidence of overweight/obesity: The SUN cohort. Obesity (Silver Spring). 2017;25(6):997-1005. https://doi.org/10.1002/oby.21833
  49. Buscail C, Sabate JM, Bouchoucha M, Kesse-Guyot E, Hercberg S, Benamouzig R, Julia C. Western Dietary Pattern Is Associated with Irritable Bowel Syndrome in the French NutriNet Cohort. Nutrients. 2017;9(9):986.  https://doi.org/10.3390/nu9090986
  50. Khayyatzadeh SS, Esmaillzadeh A, Saneei P, Keshteli AH, Adibi P. Dietary patterns and prevalence of irritable bowel syndrome in Iranian adults. Neurogastroenterology and Motility. 2016;28(12):1921-1933. https://doi.org/10.1111/nmo.12895
  51. Eswaran S, Tack J, Chey WD. Food: the forgotten factor in the irritable bowel syndrome. Gastroenterology Clinics of North America. 2011;40(1):141-162.  https://doi.org/10.1016/j.gtc.2010.12.012
  52. Livzan MA, Nikolaev NA, Skirdenko YuP, Fedorin MM, Gorbenko AV, Andreev KA, Andreeva EK, Ivanov AI, Ivakhnenko AT. Nutritional behavior in a student community. Kremlin Medicine Journal. 2019;2:13—16. (In Russ.). https://doi.org/10.26269/tvs8-by34
  53. Kostenko MB, Livzan MA. Mekhanizmy razvitiia sindroma razdrazhennogo kishechnika. Sibirskij Zhurnal Gastrojenterologii i Gepatologii. 2000;10:32-35. (In Russ).
  54. Chirila I, Petrariu FD, Ciortescu I, Mihai C, Drug VL. Diet and irritable bowel syndrome. Journal of Gastrointestinal and Liver Diseases. 2012;21(4):357-362. 
  55. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. American Journal of Clinical Nutrition. 2004;79(4):537-543.  https://doi.org/10.1093/ajcn/79.4.537
  56. Bruckert E, Rosenbaum D. Lowering LDL-cholesterol through diet: potential role in the statin era. Current Opinion in Lipidology. 2011;22(1):43-48.  https://doi.org/10.1097/MOL.0b013e328340b8e7
  57. Livzan MA, Kolbina MV, Matoshina IV, Zherebilov VV, Nikolaev NA, Hrapova IA, Loseva YUP. Dnevnik Kazanskoj Medicinskoj Shkoly. 2014;1(4):44-48. (In Russ.).
  58. Chang L. The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome. Gastroenterology. 2011; 140(3):761-765.  https://doi.org/10.1053/j.gastro.2011.01.032
  59. Singh P, Agnihotri A, Pathak MK, Shirazi A, Tiwari RP, Sreenivas V, Sagar R, Makharia GK. Psychiatric, somatic and other functional gastrointestinal disorders in patients with irritable bowel syndrome at a tertiary care center. Journal of Neurogastroenterology and Motility. 2012;18(3):324-331.  https://doi.org/10.5056/jnm.2012.18.3.324
  60. Larauche M, Mulak A, Taché Y. Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study. Journal of Neurogastroenterology and Motility. 2011;17(3):213-234.  https://doi.org/10.5056/jnm.2011.17.3.213
  61. Larauche M, Kiank C, Tache Y. Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications. Journal of Physiology and Pharmacology. 2009;60(suppl 7):33-46. 
  62. Vicennati V, Ceroni L, Genghini S, Patton L, Pagotto U, Pasquali R. Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity. Obesity (Silver Spring). 2006;14(2):235-243.  https://doi.org/10.1038/oby.2006.30
  63. Bujalska IJ, Kumar S, Hewison M, Stewart PM. Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase. Endocrinology. 1999;140(7):3188-3196. https://doi.org/10.1210/endo.140.7.6868

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