Human Microbiome: age-related changes and functions

Kaibysheva V.O.; Zharova M.E.; Filimendikova K.Yu.; Nikonov E.L.

doi:https://doi.org/10.17116/dokgastro2020902142

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Abstract:

Objective. To analyse information about age-related changes of the microbiome and its most important functions. Key points. Significant interest to the human microbiome in recent decades was determined by the development of new diagnostic methods, including 16S ribosomal RNA sequencing, whole-genome sequencing, chromatospectrometry, and others. These methods have significantly improved understanding of the role of intestinal microbiota and its unique metabolites in regulation of various physiological functions, including colonization resistance of the mucous membranes, metabolism, development, and homeostasis of immune and nervous systems. Conclusion. Despite a large amount of available information about the human microbiome, an understanding of its function in the human body is still far from perfect, which necessitates further research.

Keywords:

microbiota

microbiome

fecal microbiota transplantation

probiotics

Authors:

Kaibysheva V.O.

N.I. Pirogov Russian National Research Medical University, Moscow, Russia;
City Clinical Hospital №31, Moscow, Russia

ORCID: 0000-0003-0114-3700

Zharova M.E.

Pirogov Russian National Research Medical University, Moscow, Russia;
Scientific Research Institute of Healthcare Organizatiob and Medical Management, Moscow, Russia

ORCID: 0000-0002-8325-5927

Filimendikova K.Yu.

Yaroslavl State Medical University, Yaroslavl, Russia

Nikonov E.L.

FGBU "Poliklinika #1" Upravleniia delami Prezidenta RF

Scopus AuthorID: 57216680476
ResearcherID: T-9090-2017
ORCID: 0000-0003-3021-6534

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References:

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