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Osadchuk A.M.

Russian Medical Academy of Continuous Professional Education

Loranskaya I.D.

Russian Medical Academy of Continuous Professional Education

Osadchuk M.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Khamatnurova L.R.

IDK Medical Company

Proton pump inhibitors: positive and negative properties. On the 45th anniversary of their discovery

Authors:

Osadchuk A.M., Loranskaya I.D., Osadchuk M.A., Khamatnurova L.R.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2024;27(11): 135‑140

DOI: 10.17116/profmed202427111135

Views: 270

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Table of contents

To cite this article:

Osadchuk AM, Loranskaya ID, Osadchuk MA, Khamatnurova LR. Proton pump inhibitors: positive and negative properties. On the 45th anniversary of their discovery. Russian Journal of Preventive Medicine. 2024;27(11):135‑140. (In Russ.)
https://doi.org/10.17116/profmed202427111135

Подписка 2025 (Russian Journal of Preventive Medicine)
 
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Today, every tenth European takes proton pump inhibitors (PPI) on a regular basis. PPIs are safe drugs; still, their continuous intake increases the possibility of adverse events significantly. There is evidence that long-term use of PPIs is associated with a higher cardiovascular risk, the risk of synergism and antagonism of drug interactions with PPIs, digestive infections, kidney diseases, dementia, malabsorption syndrome, oncological diseases, myopathy, and microscopic colitis. Therefore, a search for optimal ways of using PPIs and prevention of possible side effects with their long-term use is an acute medico-social issue. This is especially true considering that about half of PPI prescription cases do not include a proper assessment of the PPI feasibility. The article aims to describe the side effects of long-term use of PPI and measures to prevent them, considering the achievements of modern gastroenterology.

Keywords:

proton pump inhibitors
adverse events
prevention
probiotics
malabsorption

Authors:

Osadchuk A.M.

Russian Medical Academy of Continuous Professional Education

Loranskaya I.D.

Russian Medical Academy of Continuous Professional Education

Osadchuk M.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Khamatnurova L.R.

IDK Medical Company

Received:

05.04.2024

Accepted:

14.07.2024

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