The state of gut microbiota and clinical-metabolic features in children with overweight and obesity

Gurova M.M.; Novikova V.P.; Khavkin A.I.

doi:https://doi.org/10.17116/dokgastro201870314

Gurova M.M.

Saint-Petersburg State Pediatric Medical University, Saint- Petersburg, Russia

Novikova V.P.

Saint-Petersburg State Pediatric Medical University, Saint- Petersburg, Russia

Khavkin A.I.

Academician Yu.E. Vel’tishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russia, Moscow, Russia

The state of gut microbiota and clinical-metabolic features in children with overweight and obesity

Authors:

Gurova M.M., Novikova V.P., Khavkin A.I.

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Journal: Russian Journal of Evidence-Based Gastroenterology. 2018;7(3): 4‑10

DOI: 10.17116/dokgastro201870314

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To cite this article:

Gurova MM, Novikova VP, Khavkin AI. The state of gut microbiota and clinical-metabolic features in children with overweight and obesity. Russian Journal of Evidence-Based Gastroenterology. 2018;7(3):4‑10. (In Russ.)
https://doi.org/10.17116/dokgastro201870314

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)

Использование инфографики авторами научных работ

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Abstract:

Gut microbiota is currently considered as the factor initiating and maintaining energy balance disturbances. It was analyzed the state of gut microbiota in children with overweight and obesity using gas chromatography—mass spectrometry (GC—MS) in order to determine the changes of microbial communities depending on the state of gastrointestinal tract, lipid and carbohydrate metabolism. There were 120 children aged 12—15 years. Group 1 included 60 children with overweight (BMI 24.2±1.12 kg/m2), group 2—60 children with obesity grade 1—2 (BMI 31.6±4.3 kg/m2). Control group consisted of 30 schoolchildren with BMI 17.9±1.1 kg/m2 and the 1st group of health. Changes of gut microbiota due to conventionally cultivated strains and those diagnosed by only GC—MS were observed in all children of groups 1 and 2. These changes were presented by decreased level of normal microflora (bifidobacteria, lactobacilli, propionibacteria) and increased contents of opportunistic microflora (Streptococcus mutans, actinobacteria, clostridia, staphylococci, rhodococci) and fungi. Correlation between lipid metabolism disturbances and changes of gut microbiota was revealed. Therefore, micro anisms with pro-atherogenic activity (Str. mutans, actinobacteria, clostridia) and those with protective properties (bifidobacteria and propionibacteria) were able to be determined.

Keywords:

gut microbiota

children

obesity

overweight

gas chromatography—mass spectrometry

Authors:

Gurova M.M.

Saint-Petersburg State Pediatric Medical University, Saint- Petersburg, Russia

Novikova V.P.

Saint-Petersburg State Pediatric Medical University, Saint- Petersburg, Russia

Khavkin A.I.

Academician Yu.E. Vel’tishchev Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical University, Ministry of Health of the Russia, Moscow, Russia

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