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Baydarova M.D.

Federal state budgetary institution «A.V. Vishnevsky Institute of Surgery», Moscow, Russia

Tupikin K.A.

Federal state budgetary institution «A.V. Vishnevsky Institute of Surgery», Moscow, Russia

Andreytseva O.I.

Federal state budgetary institution «A.V. Vishnevsky Institute of Surgery», Moscow, Russia

Hereditary hemorrhagic teleangiectasia: the topical problems of diagnostics and surgical treatment

Authors:

Baydarova M.D., Tupikin K.A., Andreytseva O.I.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2016;5(4): 36‑43

DOI: 10.17116/dokgastro20165436-43

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To cite this article:

Baydarova MD, Tupikin KA, Andreytseva OI. Hereditary hemorrhagic teleangiectasia: the topical problems of diagnostics and surgical treatment. Russian Journal of Evidence-Based Gastroenterology. 2016;5(4):36‑43. (In Russ.)
https://doi.org/10.17116/dokgastro20165436-43

Подписка 2025 (Russian Journal of Evidence-Based Gastroenterology)
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Hereditary hemorrhagic telangiectasia is a rare autosomal dominant disease. Despite some progress in the study of its etiology and pathogenesis, the treatment remains ill-defined. In this review article, the current state of the problem, the main diagnostic tests and principles of medicinal and surgical treatment of this pathology are considered.

Keywords:

hereditary hemorrhagic telangiectasia
diagnostics
surgical treatment

Authors:

Baydarova M.D.

Federal state budgetary institution «A.V. Vishnevsky Institute of Surgery», Moscow, Russia

Tupikin K.A.

Federal state budgetary institution «A.V. Vishnevsky Institute of Surgery», Moscow, Russia

Andreytseva O.I.

Federal state budgetary institution «A.V. Vishnevsky Institute of Surgery», Moscow, Russia

List of references:

  1. Porteous ME, Burn J, Proctor SJ. Hereditary haemorrhagic telangiectasia: a clinical analysis. J Med Genet. 1992;29(8):527-530.
  2. Prasad C, Chudley AE. History of genetics through philately: Sir William Osler (1849-1919) and the Osler-Weber-Rendu syndrome. Clin Genet. 2002;61(6):404-407.
  3. Hanes F. Multiple hereditary telangiectases causing hemorrhage (hereditary hemorrhagic telangiectasia). Bull Johns Hopkins Hosp. 1909;20:63-73.
  4. Plauchu H, de Chadarevian JP, Bideau A, Robert JM. Agerelated clinical profile of hereditary hemorrhagic telangiectasia in an epidemiologically recruited population. Am J Med Genet. 1989;32(3):291-297.
  5. Geisthoff UW, Schneider G, Fischinger J, Plinkert PK. Hereditary hemorrhagic telangiectasia (Osler’s disease): an interdisciplinary challenge. HNO. 2002;50(2):114-128.
  6. Faughnan ME, Palda VA, Garcia-Tsao G, Geisthoff UW, McDonald J, Proctor DD, Spears J, Brown DH, Buscarini E, Chesnutt MS, Cottin V, Ganguly A,Gossage JR, Guttmacher AE, Hyland RH, Kennedy SJ, Korzenik J, Mager JJ, Ozanne AP, Piccirillo JF, Picus D, Plauchu H, Porteous ME, Pyeritz RE, Ross DA, Sabba C, Swanson K, Terry P, Wallace MC, Westermann CJ, White RI, Young LH, Zarrabeitia R; HHT Foundation International — Guidelines Working Group. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet. 2011;48(2):73-87. doi:10.1136/jmg.2009.069013
  7. Shovlin CL, Hughes JM, Tuddenham EG, Temperley I, Perembelon YF, Scott J, Seidman CE, Seidman JG. A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3. Nat Genet. 1994;6(2):205-209.
  8. Bayrak-Toydemir P, McDonald J, Markewitz B, Lewin S, Miller F, Chou LS, Gedge F, Tang W, Coon H, Mao R. Genotype-phenotype correlation in hereditary hemorrhagic telangiectasia: mutations and manifestations. Am J Med Genet A. 2006;140(5):463-470.
  9. Letteboer TG, Mager HJ, Snijder RJ, Lindhout D, Ploos van Amstel HK, Zanen P, Westermann KJ. Genotypephenotype relationship for localization and age distribution of telangiectases in hereditary hemorrhagic telangiectasia. Am J Med Genet A. 2008;146A(21):2733-2739. doi:10.1002/ajmg.a.32243
  10. Lesca G, Olivieri C, Burnichon N, Pagella F, Carette MF, Gilbert-Dussardier B, Goizet C, Roume J, Rabilloud M, Saurin JC, Cottin V, Honnorat J, Coulet F, Giraud S, Calender A, Danesino C, Buscarini E, Plauchu H: Genotype-phenotype correlations in hereditary hemorrhagic telangiectasia: data from the French-Italian HHT network. Genet Med. 2007;9(1):14-22.
  11. Letteboer TG, Mager JJ, Snijder RJ, Koeleman BP, Lindhout D, Ploos van Amstel JK, Westermann CJ. Genotypephenotype relationship in hereditary haemorrhagic telangiectasia. J Med Genet. 2006;43(4):371-377.
  12. Sabbà C, Pasculli G, Suppressa P, D'Ovidio F, Lenato GM, Resta F, Assennato G, Guanti G. Life expectancy in patients with hereditary haemorrhagic telangiectasia. QJM. 2006;99(5):327-334.
  13. Cole SG, Begbie ME, Wallace GM, Shovlin CL. A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5. J Med Genet. 2005;42(7):577-582.
  14. Bayrak-Toydemir P, McDonald J, Akarsu N, Toydemir RM, Calderon F, Tuncali T, Tang W, Miller F, Mao R. A fourth locus for hereditary hemorrhagic telangiectasia maps to chromosome 7. Am J Med Genet A. 2006;140(20):2155-2162.
  15. Wooderchak-Donahue WL1, McDonald J, O'Fallon B, Upton PD, Li W, Roman BL, Young S, Plant P, Fülöp GT, Langa C, Morrell NW, Botella LM, Bernabeu C, Stevenson DA, Runo JR, Bayrak-Toydemir P. BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia. Am J Hum Genet. 2013;93(3):530-537. doi:10.1016/j.ajhg.2013.07.004
  16. Iyer NK, Burke CA, Leach BH, Parambil JG. SMAD4 mutation and the combined syndrome of juvenile polyposis syndrome and hereditary haemorrhagic telangiectasia. Thorax. 2010;65(8):745-746. doi:10.1136/thx.2009.129932
  17. Williams JC, Hamilton JK, Shiller M, Fischer L, Deprisco G, Boland CR. Combined juvenile polyposis and hereditary hemorrhagic telangiectasia. Proc (Bayl Univ Med Cent). 2012;25(4):360-364.
  18. Braverman IM, Jacobson BS. Ultrastructure and three-dimensional organization of the telangiectases of hereditary hemorrhagic telangiectasia. J Invest Dermatol. 1990;95(4):422-427.
  19. Berg J, Porteous M, Reinhardt D, Gallione C, Holloway S, Umasunthar T, Lux A, McKinnon W, Marchuk D, Guttmacher A. Hereditary haemorrhagic telangiectasia: a questionnaire based study to delineate the different phenotypes caused by endoglin and ALK1 mutations. J Med Genet. 2003;40(8):585-590.
  20. Assar OS, Friedman CM, White RI Jr. The natural history of epistaxis in hereditary hemorrhagic telangiectasia. Laryngoscope. 1991;101(9):977-980.
  21. Folz BJ, Tennie J, Lippert BM, Werner JA. Natural history and control of epistaxis in a group of German patients with Rendu-Osler-Weber disease. Rhinology. 2005;43(1):40-46.
  22. Dheyauldeen S, Abdelnoor M, Bachmann-Harildstad G. The natural history of epistaxis in patients with hereditary hemorrhagic telangiectasia in the Norwegian population: a cross-sectional study. Am J Rhinol Allergy. 2001;25(4):214-218. doi:10.2500/ajra.2011.25.3616
  23. Elphick A, Shovlin CL. Relationships between epistaxis migraines and triggers in hereditary hemorrhagic telangiectasia. Laryngoscope. 2014;124(7):1521-1528. doi:10.1002/lary.24526
  24. Al-Saleh S, Mei-Zahav M, Faughnan ME, MacLusky IB, Carpenter S, Letarte M, Ratjen F. Screening for pulmonary and cerebral arteriovenous malformations in children with hereditary haemorrhagic telangiectasia. Eur Respir J. 2009;34(4):875-881. doi:10.1183/09031936.00030009
  25. Ference BA, Shannon TM, White RI, Zawin M, Burdge CM. Lifethreatening pulmonary hemorrhage with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia. Chest. 1994;106(5):1387-1390.
  26. Gossage JR, Kanj G. Pulmonary arteriovenous malformations. A state of the art review. Am J Respir Crit Care Med. 1998;158(2):643-661.
  27. Kjeldsen AD, Oxhøj H, Andersen PE, Green A, Vase P. Prevalence of pulmonary arteriovenous malformations (PAVMs) and occurrence of neurological symptoms in patients with hereditary haemorrhagic telangiectasia (HHT). J Intern Med. 2000;248(3):255-262.
  28. Cottin V, Chinet T, Lavole´ A, Corre R, Marchand E, Reynaud-Gaubert M, Plauchu H, Cordier JF; Groupe d'Etudes et de Recherche sur les Maladies «Orphelines» Pulmonaires (GERM"O"P). Pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: a series of 126 patients. Medicine (Baltimore). 2007;86(1):1-17.
  29. Dines DE, Seward JB, Bernatz PE. Pulmonary arteriovenous fistulas. Mayo Clin Proc. 1983;58(3):176-181.
  30. Shovlin CL, Jackson JE, Bamford KB, Jenkins IH, Benjamin AR, Ramadan H, Kulinskaya E. Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia. Thorax. 2008;63(3):259-266.
  31. White RI Jr, Lynch-Nyhan A, Terry P, Buescher PC, Farmlett EJ, Charnas L, Shuman K, Kim W, Kinnison M, Mitchell SE. Pulmonary arteriovenous malformations: techniques and long-term outcome of embolotherapy. Radiology. 1988;169(3):663-669.
  32. Shovlin CL, Letarte M. Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms. Thorax. 1999;54(8):714-729.
  33. Begbie ME, Wallace GM, Shovlin CL. Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): a view from the 21st century. Postgrad Med J. 2003;79(927):18-24.
  34. Bhatia S, Morrison JF, Bower TC, McGoon MD. Pulmonary hypertension in the setting of acquired systemic arteriovenous fistulas. Mayo Clin Proc. 2003;78(7):908-912.
  35. Espinosa PS, Pettigrew LC, Berger JR. Hereditary hemorrhagic telangectasia and spinal cord infarct: case report with a review of the neurological complications of HHT. Clin Neurol Neurosurg. 2008;110(5):484-491. doi:10.1016/j.clineuro.2008.01.005
  36. Maher CO, Piepgras DG, Brown RD Jr, Friedman JA, Pollock BE. Cerebrovascular manifestations in 321 cases of hereditary hemorrhagic telangiectasia. Stroke. 2001;32(4):877-882.
  37. Morgan T, McDonald J, Anderson C, Ismail M, Miller F, Mao R, Madan A, Barnes P, Hudgins L, Manning M. Intracranial hemorrhage in infants and children with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome). Pediatrics. 2002;109(1):E12.
  38. Saleh M, Carter MT, Latino GA, Dirks P, Ratjen F. Brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: clinical presentation and anatomical distribution. Pediatr Neurol. 2013;49(6):445-450. doi:10.1016/j.pediatrneurol.2013.07.021
  39. Kjeldsen AD, Vase P, Green A. Hereditary hemorrhagic telangiectasia. A population-based study on prevalence and mortality among Danish HHT patients. Ugeskr Laeger. 2000;162(25):3597-3601.
  40. Longacre AV, Gross CP, Gallitelli M, Henderson KJ, White RI Jr, Proctor DD. Diagnosis and management of gastrointestinal bleeding in patients with hereditary hemorrhagic telangiectasia. Am J Gastroenterol. 2003;98(1):59-65.
  41. Ingrosso M, Sabbà C, Pisani A, Principi M, Gallitelli M, Cirulli A, Francavilla A. Evidence of smallbowel involvement in hereditary hemorrhagic telangiectasia: a capsule-endoscopic study. Endoscopy. 2004;36(12):1074-1079.
  42. Grève E, Moussata D, Gaudin JL, Lapalus MG, Giraud S, Dupuis-Girod S, Calender A, Plauchu H, Saurin JC. High diagnostic and clinical impact of small-bowel capsule endoscopy in patients with hereditary hemorrhagic telangiectasia with overt digestive bleeding and/or severe anemia. Gastrointest Endosc. 2010;71(4):760-767. doi:10.1016/j.gie.2009.11.004
  43. Ianora AAS, Memeo M, Sabba C, Cirulli A, Rotondo A, Angelelli G. Hereditary hemorrhagic telangiectasia: multi-detector row helical CT assessment of hepatic involvement. Radiology. 2004;230(1):250-259.
  44. Buscarini E, Danesino C, Olivieri C, Lupinacci G, De Grazia F, Reduzzi L, Blotta P, Gazzaniga P, Pagella F, Grosso M, Pongiglione G, Buscarini L, Plauchu H, Zambelli A. Doppler ultrasonographic grading of hepatic vascular malformations in hereditary hemorrhagic telangiectasia — results of extensive screening. Ultraschall Med. 2004;25:348-355.
  45. Buscarini E, Plauchu H, Garcia Tsao G, White RI Jr, Sabbà C, Miller F, Saurin JC, Pelage JP, Lesca G, Marion MJ, Perna A, Faughnan ME. Liver involvement in hereditary hemorrhagic telangiectasia: consensus recommendations. Liver Int. 2006;26(9):1040-1046.
  46. Al-Saleh S, John PR, Letarte M, Faughnan ME, Belik J, Ratjen F. Symptomatic liver involvement in neonatal hereditary hemorrhagic telangiectasia. Pediatrics. 2011;127(6):e1615-e1620. doi:10.1542/peds.2010-2366
  47. Garcia-Tsao G, Korzenik JR, Young L, Henderson KJ, Jain D, Byrd B, Pollak JS, White RI Jr. Liver disease in patients with hereditary hemorrhagic telangiectasia. N Engl J Med. 2000;343(13):931-936.
  48. Ravard G, Soyer P, Boudiaf M, Terem C, Abitbol M, Yeh JF, Brouard R, Hamzi L, Rymer R. Hepatic involvement in hereditary hemorrhagic telangiectasia: helical computed tomography features in 24 consecutive patients. J Comput Assist Tomogr. 2004;28(4):488-495.
  49. Buscarini E, Leandro G, Conte D, Danesino C, Daina E, Manfredi G, Lupinacci G, Brambilla G, Menozzi F, De Grazia F, Gazzaniga P, Inama G, Bonardi R,Blotta P, Forner P, Olivieri C, Perna A, Grosso M, Pongiglione G, Boccardi E, Pagella F, Rossi G, Zambelli A. Natural history and outcome of hepatic vascular malformations in a large cohort of patients with hereditary hemorrhagic teleangiectasia. Dig Dis Sci. 2011;56(7):2166-2178. doi:10.1007/s10620-011-1585-2
  50. Memeo M, Scardapane A, De Blasi R, Sabbà C, Carella A, Angelelli G. Diagnostic imaging in the study of visceral involvement of hereditary hemorrhagic telangiectasia. Radiol Med. 2008;113(4):547-566. doi:10.1007/s11547-008-0276-3
  51. Martini GA. The liver in hereditary hemorrhagic telangiectasia: an inborn error of vascular structure with multiple manifestations: a reappraisal. Gut. 1978;19(6):531-537.
  52. Singh S, Swanson KL, Hathcock MA, Kremers WK, Pallanch JF, Krowka MJ, Kamath PS. Identifying the presence of clinically significant hepatic involvement in hereditary haemorrhagic telangiectasia using a simple clinical scoring index. J Hepatol. 2014;61(1):124-131. doi:10.1016/j.jhep.2014.02.028
  53. Lenato GM, Lastella P, Di Giacomo MC, Resta N, Suppressa P, Pasculli G, Sabbà C, Guanti G. DHPLC-based mutation analysis of ENG and ALK-1genes in HHT Italian population. Hum Mutat. 2006;27(2):213-214.
  54. Olivieri C, Pagella F, Semino L, Lanzarini L, Valacca C, Pilotto A, Corno S, Scappaticci S, Manfredi G, Buscarini E, Danesino C. Analysis of ENG and ACVRL1 genes in 137 HHT Italian families identifies 76 different mutations (24 novel). Comparison with other European studies. J Hum Genet. 2007;52(10):820-829.
  55. Odorico JS, Hakim MN, Becker YT, Van der Werf W, Musat A, Knechtle SJ, D'Alessandro AM, Kalayoglu M. Liver transplantation as definitive therapy for complications after arterial embolization for hepatic manifestations of hereditary hemorrhagic telangiectasia. Liver Transpl Surg. 1998;4(6):483-490.
  56. Shovlin CL, Guttmacher AE, Buscarini E, Faughnan ME, Hyland RH, Westermann CJ, Kjeldsen AD, Plauchu H. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu—Osler—Weber syndrome). Am J Med Genet. 2000;91(1):66-67.
  57. Kornelia EC Wirsching, Thomas S Kühnel. Update on Clinical Strategies in Hereditary Hemorrhagic Telangiectasia From an ENT Point of View. Clinical and Experimental Otorhinolaryngology. 2016. doi:10.21053/ceo.2016.00318
  58. McCaffrey TV, Kern EB, Lake CF. Management of epistaxis in hereditary hemorrhagic telangiectasia. Review of 80 cases. Arch Otolaryngol. 1977;103(11):627-630.
  59. McCabe WP, Kelly AP Jr. Management of epistaxis in Osler-Weber-Rendu disease: recurrence of telangiectases within a nasal skin graft. Plast Reconstr Surg. 1972;50(2):114-118.
  60. Bergler W, Sadick H, Gotte K, Riedel F, Hormann K. Topical estrogens combined with argon plasma coagulation in the management of epistaxis in hereditary hemorrhagic telangiectasia. Ann Otol Rhinol Laryngol. 2002;111(3):222-228.
  61. Klepfish A, Berrebi A, Schattner A. Intranasal tranexamic acid treatment for severe epistaxis in hereditary hemorrhagic telangiectasia. Arch Intern Med. 2001;161(5):767.
  62. Shah RK, Dhingra JK, Shapshay SM. Hereditary hemorrhagic telangiectasia: a review of 76 cases. Laryngoscope. 2002;112(5):767-773.
  63. Mahoney EJ, Shapshay SM. Nd-YAG laser photocoagulation for epistaxis associated with hereditary hemorrhagic telangiectasia. Laryngoscope. 2005;115(2):373-375.
  64. Werner JA, Lippert BM, Geisthoff UW, Rudert H. Nd:YAG laser therapy of recurrent epistaxis in hereditary hemorrhagic telangiectasia. Laryngorhinootologie. 1997;76(8):495-501.
  65. Karapantzos I, Tsimpiris N, Goulis DG, Van Hoecke H, Van Cauwenberge P, Danielides V. Management of epistaxis in hereditary hemorrhagic telangiectasia by Nd:YAG laser and quality of life assessment using the HR-QoL questionnaire. Eur Arch Otorhinolaryngol. 2005;262(10):830-833.
  66. Bergler W, Riedel F, Baker-Schreyer A, Juncker C, Hormann K. Argon plasma coagulation for the treatment of hereditary hemorrhagic telangiectasia. Laryngoscope. 1999;109(1):15-20.
  67. Siegel MB, Keane WM, Atkins JF Jr, Rosen MR. Control of epistaxis in patients with hereditary hemorrhagic telangiectasia. Otolaryngol Head Neck Surg. 1991;105(5):675-679.
  68. Elden L, Montanera W, Terbrugge K, Willinsky R, Lasjaunias P, Charles D. Angiographic embolization for the treatment of epistaxis: a review of 108 cases. Otolaryngol Head Neck Surg. 1994;111(1):44-50.
  69. Andersen PJ, Kjeldsen AD, Nepper-Rasmussen J. Selective embolization in the treatment of intractable epistaxis. Acta Otolaryngol. 2005;125(3):293-297.
  70. Willemse RB, Mager JJ, Westermann CJ, Overtoom TT, Mauser H, Wolbers JG. Bleeding risk of cerebrovascular malformations in hereditary hemorrhagic telangiectasia. J Neurosurg. 2000;92(5):779-784.
  71. Rutgeerts P, Van Gompel F, Geboes K, Vantrappen G, Broeckaert L, Coremans G. Long term results of treatment of vascular malformations of the gastrointestinal tract by neodymium Yag laser photocoagulation. Gut. 1985;26(6):586-593.
  72. Chavan A, Luthe L, Gebel M, Barg-Hock H, Seifert H, Raab R, Kirchhoff T, Schmuck B. Complications and clinical outcome of hepatic artery embolisation in patients with hereditary haemorrhagic telangiectasia. European Journal of Radiology. 2013;23(4):951-957.
  73. Trotter J F, Suhocki P V, Lina J R, Martin LW, Parriah J L, Swantkowski T. Hereditary hemorrhagic telangiectasia causing high output cardiac failure: treatment with transcatheter embolization. Am J Gastroenterol. 1998;93(9):1569-1571.
  74. Caselitz M, Wagner S, Chavan A, Gebel M, Bleck JS, Wu A, Schlitt HJ, Galanski M, Manns MP. Clinical outcome of transfemoral embolization in patients with arteriovenous malformations of the liver in hereditary haemorrhagic telangiectasia (Weber-Rendu-Osler disease). Gut. 1998;42(1):123-126.
  75. Bauer T, Britton P, Lomas D, Wight D G, Freiend P J, Alexander G J. Liver transplantation for hepatic arteriovenous malformation in hereditary haemorrhagic telangiectasia. J Hepatol. 1995;22(5):586-590.
  76. Boillot O, Bianco F, Viale JP, Mion F, Mechet I, Gille D, Delaye J, Paliard P, Plauchu H. Liver transplantation resolves the hyperdynamic circulation in hereditary hemorrhagic telangiectasia with hepatic involvement. Gastroenterology. 1999;116(1):187-192.
  77. Pfitzmann R, Heise M, Langrehr JM, Jonas S, Steinmüller T, Podrabsky P, Ewert R, Settmacher U, Neuhaus R, Neuhaus P. Liver transplantation for treatment of intrahepatic Osler’s disease: first experience. Transplantation. 2001;72(2):237-241.
  78. Azoulay D, Precetti S, Emile JF, Ichai P, Gillon MC, Duclos-Vallée JC, Visda S, Adam R, Castaing D, Samuel D, Bismuth H. Liver transplantation for intrahepatic Rendu-Osler-Weber’s disease: the Paul Brousse hospital experience. Gastroenterol Clin Biol. 2002;26:828-834.
  79. Liu ZC, Lu XF, Yang H, Liu HD, Song X, Ning SL, Xu YF, Chen YX. Clinical Outcomes of Patients with Severe Hepatic Hereditary Hemorrhagic Telangiectasia After Banding of the Hepatic Artery and Banding/Ligation of Branches of the Hepatic Artery. Eur J Vasc Endovasc Surg. 2016;51(4):594-601. doi:10.1016/j.ejvs.2015.12.020
  80. Dupuis-Girod S, Ginon I, Saurin JC, Marion D, Guillot E, Decullier E, Roux A, Carette MF, Gilbert-Dussardier B, Hatron PY, Lacombe P, Lorcerie B, Rivière S, Corre R, Giraud S, Bailly S, Paintaud G, Ternant D, Valette PJ, Plauchu H, Faure F. Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output. JAMA. 2012;307(9):948-955.
  81. Lebrin F, Srun S, Raymond K, Martin S, van den Brink S, Freitas C, Bréant C, Mathivet T, Larrivée B, Thomas JL, Arthur HM, Westermann CJ, Disch F,Mager JJ, Snijder RJ, Eichmann A, Mummery CL. Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia. Nat Med. 2010;16(4):420-428. doi:10.1038/nm.2131
  82. Alam MA, Sami S, Babu S. Successful treatment of bleeding gastrointestinal angiodysplasia in hereditary hemorrhagic telangiectasia with thalidomide. BMJ Case Rep. 2011.pii:bcr0820114585. doi:10.1136/bcr.08.2011.4585
  83. Thalgott J, Dos-Santos-Luis D, Lebrin F. Pericytes as target in hereditary hemorrhagic telangiectasia. Front Genet. 2015;6:37. doi:10.3389/fgene.2015.00037

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