The authors present a detailed analysis of the application of the currently available antacid preparations, in the first place almagel A, in the framework of the programs for the treatment of acid-dependent diseases (ADD), such as gastroesophageal reflux disease and various gastropathies, especially those associated with the intake of non-steroidal anti-inflammatory drugs. It is shown that modern antacid preparations play an important role in the treatment of ADD. Their principal advantage is the rapid action accounting for the elimination of clinical symptoms within a very short span of time. It is concluded that the rational application of modern antacid preparations in the combination with proton pump inhibitors for the treatment of acid-dependent diseases makes it possible to achieve the good clinical results and improve the patient’s quality of life.