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Barinova I.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Buyanova S.N.

Moscow Regional Research Institute of Obstetrics and Gynecology

Glebov T.A.

Moscow Regional Research Institute of Obstetrics and Gynecology

Yudina N.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Aksyonova A.A.

Moscow Regional Research Institute of Obstetrics and Gynecology

Girya O.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Vaginal leiomyosarcoma in pregnancy

Authors:

Barinova I.V., Buyanova S.N., Glebov T.A., Yudina N.V., Aksyonova A.A., Girya O.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2023;85(4): 54‑58

DOI: 10.17116/patol20238504154

Read: 3243 times

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Table of contents

VAGINAL LEIOMYOSARCOMA IN PREGNANCY
VAGINAL LEIOMYOSARCOMA IN PREGNANCY

To cite this article:

Barinova IV, Buyanova SN, Glebov TA, Yudina NV, Aksyonova AA, Girya OV. Vaginal leiomyosarcoma in pregnancy. Russian Journal of Archive of Pathology. 2023;85(4):54‑58. (In Russ.)
https://doi.org/10.17116/patol20238504154

Подписка 2025-2 (Russian Journal of Archive of Pathology)
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The article presents a rare clinical observation of a vaginal tumor detected during pregnancy, which prevented delivery through the natural birth canal and caused a cesarean section at full term. According to the primary biopsy at 34 weeks, neurofibroma was diagnosed. In the postpartum period, due to profuse bloody discharge, the patient was admitted to the Moscow Regional Research Institute of Obstetrics and Gynecology for surgical treatment, where, according to the results of a morphological study of the removed tumor, vaginal leiomyosarcoma was diagnosed.

Keywords:

leiomyosarcoma
vagina
pregnancy

Authors:

Barinova I.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Buyanova S.N.

Moscow Regional Research Institute of Obstetrics and Gynecology

Glebov T.A.

Moscow Regional Research Institute of Obstetrics and Gynecology

Yudina N.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Aksyonova A.A.

Moscow Regional Research Institute of Obstetrics and Gynecology

Girya O.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

04.03.2023

Accepted:

19.04.2023

List of references:

  1. Safronova KV, Artem’eva AS, Nyuganen AO, Sidoruk AA, Smirnova OA, Mikaya NA, Berlev IV, Urmancheeva AF, Ul’rikh EA. Sarcomas of the lower female genital tract (vulva, vagina, and cervix): literature review and own cases. Tumors of Female Reproductive System. 2019;15(3):54-63. (In Russ.). https://doi.org/10.17650/1994-4098-2019-15-3-54-63
  2. Vitantri F, Chamim, Shadrina A. Malignant mesenchymal vaginal tumor mimicking pedunculated submucous myoma: a case report. Int J Surg Case Rep. 2022;93:106864. https://doi.org/10.1016/j.ijscr.2022.106864
  3. Schoomeester JK, Howitt BE. Leiomyosarcoma of the lower genital tract. In: The WHO Classification of Tumours Editorial Board. Female genital tumours. WHO Classification of Tumours. 5th ed. Vol 4. France, Lyon: International Agency for Research of Cancer; 2020;509-510. 
  4. Nucci MR, Malpica A. Mesenchymal lesions of the vulva and vagina. In: Nucci M, Parra-Herran C, eds. Gynecologic pathology. Foundations in diagnostic pathology. 2nd ed. Elsevier; 2019;89-118.  https://doi.org/10.1016/B978-0-323-35909-2.00004-7
  5. Kondrikov NI, Kazantseva IA, Barinova IV. Diseases of the female genital tract. Ch. 17. In: Paukov VS, ed. Manual of clinical pathology. M.: Litterra; 2018;452-455. (In Russ.).
  6. Akametalu P, Barcelon JM, Myint O, Moatamed NA, Karlan BY, Kamrava M, Cohen JG. Vaginal high-grade sarcoma in pregnancy. Gynecol Oncol Rep. 2021;38:100881. https://doi.org/10.1016/j.gore.2021.100881
  7. Okunowo AA, Ugwu AO, Owie E, Kolawole HF, Adebayo LA, Kusamotu OA, Kuku JO, Soibi-Harry AP, Ohazurike EO, Banjo AAF. Primary vaginal leiomyosarcoma: case report of a rare gynaecological malignancy and diagnostic challenge in a resource-constraint setting. Oxf Med Case Rep. 2020;2020(9): omaa081. https://doi.org/10.1093/omcr/omaa081
  8. Williams EA, Montesion M, Lincoln V, Tse JY, Hiemenz MC, Mata DA, Shah BB, Shoroye A, Alexander BM, Werth AJ, et al. HPV51-associated leiomyosarcoma: a novel class of TP53/RB1-Wildtype tumor with predilection for the female lower reproductive tract. Am J Surg Pathol. 2022;46(6):729-741.  https://doi.org/10.1097/PAS.0000000000001862
  9. Keller NA, Godoy H. Leiomyosarcoma of the vagina: an exceedingly rare diagnosis. Case Rep Obstet Gynecol. 2015;2015:363895. https://doi.org/10.1155/2015/363895
  10. Krasnopolskii VI, Buyanova SN, Shchukina NA, Popov AA. Operative gynecology. 4th ed. M.: MEDpress-inform; 2018;320. (In Russ.).
  11. Hagen J, Wilhite A, Tarbunova M, Erickson B. Successful robotic surgery for primary resection of a vaginal leiomyosarcoma: a case report. Gynecol Oncol Rep. 2019;30:100503. https://doi.org/10.1016/j.gore.2019.100503
  12. Benti TM, Mercy N, Eshetu AB, Iwuh IE, Kassa MW. Recurrent vaginal epithelioid leiomyosarcoma; a case report from Botswana and review of the literature. Afr J Reprod Health. 2021;25(1):161-168.  https://doi.org/10.29063/ajrh2021/v25i1.17
  13. Khafagy AM, Prescott LS, Malpica A, Westin SN. Unusual indolent behavior of leiomyosarcoma of the vagina: is observation a viable option? Gynecol Oncol Rep. 2017;21:28-30.  https://doi.org/10.1016/j.gore.2017.06.007
  14. Vang R, Seidman JD, Yemelyanova A. Differential diagnosis in surgical pathology: gynecologic tract. Philadelphia: Wolters Kluwer; 2017;544. 
  15. Andreeva YuYu, Frank GA, eds. Tumors of the body and cervix of the uterus. Manual of morphological diagnostics and genetics. M.: Practical medicine; 2015;302. (In Russ.).

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