Mucins expression in gastric cancer: connection of MUC status with clinical, morphological and prognostic characteristics of the tumor

Danilova NV, Chayka AV, Khomyakov VM, Oleynikova NA, Andreeva YuYu, Polushkina TV, Sotnikova TN. Mucins expression in gastric cancer: connection of MUC status with clinical, morphological and prognostic characteristics of the tumor. Russian Journal of Archive of Pathology. 2023;85(1):16‑28. (In Russ.)
https://doi.org/10.17116/patol20238501116

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

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OBJECTIVE

Clarification of the prognostic value and relationship of MUC-phenotypes of gastric cancer with clinical and morphological parameters.

MATERIAL AND METHODS

Surgical material from 310 patients with a verified diagnosis of gastric cancer was studied. Samples were immunohistochemically stained with antibodies to MUC2, CD10, MUC5AC. The results were compared with clinical and morphological characteristics of gastric cancer and patient survival data.

RESULTS

The MUC-null and MUC-mix groups significantly differ in the prevalence of subtotal/total tumors from the MUC-I group (p=0.022 and p=0.007, respectively), where there are significantly fewer such tumors. Tubular tumors were more common in the MUC-null group compared to the MUC-G (p=0.026) and MUC-mix (p=0.006) groups, and there were fewer cases with the presence of “signet-ring” cells in the MUC-null group (p=0.000). When studying the discohesive histological type, the literature data on smaller tumor sizes and a lower frequency of lymph node metastasis for MUC-G status were not confirmed, but a more frequent proximal localization of MUC-I tumors was found (p=0.003). No statistically significant differences in survival were found in the analysis of the total sample. Differences in survival were found only in discohesive cancers, where the best survival was recorded for the MUC-null group, and the worst for the MUC-mix group (p=0.022). MUC status is not an independent predictor of gastric cancer (HR=1.662, p=0.093).

CONCLUSION

Between tumors with different MUC statuses, there were differences in localization and belonging to individual histological types. Significant differences in survival were found only for discohesive cancers with MUC-null and MUC-mix statuses. Separation of gastric cancers according to MUC status may have only limited predictive value in selected histological forms of cancer.

Keywords:

gastric cancer

gastric adenocarcinoma

immunohistochemistry

MUC-status

MUC2

CD10

MUC5AC

survival

Authors:

Danilova N.V.

Lomonosov Moscow State University

SPIN RSCI: 6878-2025
Scopus AuthorID: 36613033400
ResearcherID: H-6477-2014
ORCID: 0000-0001-7848-6707

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

SPIN RSCI: 6781-1890
Scopus AuthorID: 57221940671
ORCID: 0000-0002-2178-9317

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

SPIN RSCI: 4081-7701
Scopus AuthorID: 56740937000
ORCID: 0000-0001-8301-4528

Oleynikova N.A.

Lomonosov Moscow State University

SPIN RSCI: 4076-2637
Scopus AuthorID: 57193513523
ResearcherID: H-7672-2014
ORCID: 0000-0001-8564-8874

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

SPIN RSCI: 6504-2551
Scopus AuthorID: 8656328100
ORCID: 0000-0003-4749-6608

Polushkina T.V.

Lomonosov Moscow State University

ORCID: 0000-0001-5074-3513

Sotnikova T.N.

I.V. Davydovsky City Clinical Hospital

ORCID: 0000-0002-6482-1110

Received:

16.09.2022

Accepted:

26.10.2022

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