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Danilova N.V.

Lomonosov Moscow State University

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Oleynikova N.A.

Lomonosov Moscow State University

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Polushkina T.V.

Lomonosov Moscow State University

Sotnikova T.N.

I.V. Davydovsky City Clinical Hospital

Mucins expression in gastric cancer: connection of MUC status with clinical, morphological and prognostic characteristics of the tumor

Authors:

Danilova N.V., Chayka A.V., Khomyakov V.M., Oleynikova N.A., Andreeva Yu.Yu., Polushkina T.V., Sotnikova T.N.

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Journal: Russian Journal of Archive of Pathology. 2023;85(1): 16‑28

DOI: 10.17116/patol20238501116

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To cite this article:

Danilova NV, Chayka AV, Khomyakov VM, Oleynikova NA, Andreeva YuYu, Polushkina TV, Sotnikova TN. Mucins expression in gastric cancer: connection of MUC status with clinical, morphological and prognostic characteristics of the tumor. Russian Journal of Archive of Pathology. 2023;85(1):16‑28. (In Russ.)
https://doi.org/10.17116/patol20238501116

Подписка 2025 (Russian Journal of Archive of Pathology)
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OBJECTIVE

Clarification of the prognostic value and relationship of MUC-phenotypes of gastric cancer with clinical and morphological parameters.

MATERIAL AND METHODS

Surgical material from 310 patients with a verified diagnosis of gastric cancer was studied. Samples were immunohistochemically stained with antibodies to MUC2, CD10, MUC5AC. The results were compared with clinical and morphological characteristics of gastric cancer and patient survival data.

RESULTS

The MUC-null and MUC-mix groups significantly differ in the prevalence of subtotal/total tumors from the MUC-I group (p=0.022 and p=0.007, respectively), where there are significantly fewer such tumors. Tubular tumors were more common in the MUC-null group compared to the MUC-G (p=0.026) and MUC-mix (p=0.006) groups, and there were fewer cases with the presence of “signet-ring” cells in the MUC-null group (p=0.000). When studying the discohesive histological type, the literature data on smaller tumor sizes and a lower frequency of lymph node metastasis for MUC-G status were not confirmed, but a more frequent proximal localization of MUC-I tumors was found (p=0.003). No statistically significant differences in survival were found in the analysis of the total sample. Differences in survival were found only in discohesive cancers, where the best survival was recorded for the MUC-null group, and the worst for the MUC-mix group (p=0.022). MUC status is not an independent predictor of gastric cancer (HR=1.662, p=0.093).

CONCLUSION

Between tumors with different MUC statuses, there were differences in localization and belonging to individual histological types. Significant differences in survival were found only for discohesive cancers with MUC-null and MUC-mix statuses. Separation of gastric cancers according to MUC status may have only limited predictive value in selected histological forms of cancer.

Keywords:

gastric cancer
gastric adenocarcinoma
immunohistochemistry
MUC-status
MUC2
CD10
MUC5AC
survival

Authors:

Danilova N.V.

Lomonosov Moscow State University

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Oleynikova N.A.

Lomonosov Moscow State University

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Polushkina T.V.

Lomonosov Moscow State University

Sotnikova T.N.

I.V. Davydovsky City Clinical Hospital

Received:

16.09.2022

Accepted:

26.10.2022

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