The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Danilova N.V.

Lomonosov Moscow State University

Mikhailov I.A.

Center for Expertise and Quality Control of Medical Care;
Lomonosov Moscow State University

Kalinin D.V.

National Medical Research Center of Surgery named after A.V. Vishnevsky of Ministry of health of the Russian Federation

Oleynikova N.A.

Lomonosov Moscow State University

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Kakotkin V.V.

Lomonosov Moscow State University

Yudin M.Yu.

Separate subdivision «SM-Medica» of «SM-Clinic», LLC

Vychuzhanin D.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Polushkina T.V.

Lomonosov Moscow State University

Study of gastric adenocarcinomas association with the Epstein-Barr virus-encoded small RNAs

Authors:

Danilova N.V., Mikhailov I.A., Kalinin D.V., Oleynikova N.A., Chayka A.V., Khomyakov V.M., Kakotkin V.V., Yudin M.Yu., Vychuzhanin D.V., Andreeva Yu.Yu., Polushkina T.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(2): 5‑12

DOI: 10.17116/patol2022840215

Read: 1752 times

Download PDF (RU)
Contact the author
Table of contents

STUDY OF GASTRIC ADENOCARCINOMAS ASSOCIATION WITH THE EPSTEIN-BARR VIRUS-ENCODED SMALL RNAS
STUDY OF GASTRIC ADENOCARCINOMAS ASSOCIATION WITH THE EPSTEIN-BARR VIRUS-ENCODED SMALL RNAS

To cite this article:

Danilova NV, Mikhailov IA, Kalinin DV, et al. . Study of gastric adenocarcinomas association with the Epstein-Barr virus-encoded small RNAs. Russian Journal of Archive of Pathology. 2022;84(2):5‑12. (In Russ.)
https://doi.org/10.17116/patol2022840215

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The phenomenon of tumor budding in gastric cancer. Russian Journal of Archive of Pathology. 2025;(2):79-87
Microsatellite instability as a possible diagnostic marker of the gastric mucosa dysplasia. Russian Journal of Archive of Pathology. 2025;(3):5-16
Prognostic significance and comparison of methods for calculating tumor budding in gastric cancer. Russian Journal of Archive of Pathology. 2025;(3):17-25
Another sight at Gastric Cancer Mole­cular Classification: novel subtypes based on expression of CDX-2, E-cadherin, Epstein-Barr virus RNAs, MMR proteins. Russian Journal of Archive of Pathology. 2025;(3):49-61
Study of serum cyto­kine concentration in primary patients with gastric cancer. P.A. Herzen Journal of Onco­logy. 2025;(2):25-29
Total gastrectomy with preserving duodenal passage by double tract reco­nstruction in patients with gastric cancer. Piro­gov Russian Journal of Surgery. 2025;(6):35-43
Technical aspe­cts of lapa­roscopic formation of gastroduodenoanastomosis (Billroth-I) during distal rese­ction in patients with gastric cancer. Endo­scopic Surgery. 2025;(3):44-51
Intra-abdominal pressurized aero­sol chemotherapy after proximal gastrectomy with double-tract reco­nstruction in a patient with loca­lly adva­nced gastric cancer. P.A. Herzen Journal of Onco­logy. 2025;(3):78-82
Standards of surgical approach in combined treatment of patients with loca­lly adva­nced gastric cancer. P.A. Herzen Journal of Onco­logy. 2025;(3):100-106
Multivisceral surgeries with pancreatoduodenectomy for gastric cancer: imme­diate and long-term resu­lts. Piro­gov Russian Journal of Surgery. 2025;(8):30-38
Abstract:

OBJECTIVE

Assessment of the incidence of EBV-associated gastric adenocarcinomas in a sample of Russian patients, as well as clarification of the clinical and morphological characteristics and median survival of patients with EBV-associated gastric cancer.

MATERIAL AND METHODS

We used samples of surgical material from 282 patients with a verified diagnosis of gastric cancer. Each sample was stained by in situ hybridization using primers for the Epstein-Barr virus-encoded small RNAs (EBER). The results obtained were compared with the main clinical and morphological characteristics of gastric cancer.

RESULTS

The detection rate of EBV-associated gastric adenocarcinoma in our sample was 9.57%. EBER-positive tumors much more often (p=0.021) belong to the intermediate type according to the P. Lauren classification (66.67%) in comparison with EBER-negative tumors (38.82%). EBER-positive tumors significantly more often (p=0.035) belong to high-grade tumors — 75.00% in comparison with EBER-negative tumors (52.13%). The overall median survival of all patients with EBER-positive tumors (53.5 months) was higher compared to the overall median survival of all patients with EBER-negative tumors — 36.5 months (p=0.5379). The median survival of patients with EBER-positive stage III tumors (30.0 months) was also higher compared to that for patients with EBER-negative tumors — 20.0 months (p=0.5622). It was found that a single EBER status is not a significant prognostic factor (HR=1.0143; CI: 0.9897—1.0196).

CONCLUSION

Separately taken EBER-status is not a significant independent prognostic factor and can be considered only in conjunction with the «classical» clinical and morphological characteristics, primarily with the stage of the tumor process, since it is they that determine the prognostic properties of the tumor.

Keywords:

EBER
Epstein-Barr virus
EBV-associated gastric adenocarcinoma
gastric cancer
in situ hybridization

Authors:

Danilova N.V.

Lomonosov Moscow State University

Mikhailov I.A.

Center for Expertise and Quality Control of Medical Care;
Lomonosov Moscow State University

Kalinin D.V.

National Medical Research Center of Surgery named after A.V. Vishnevsky of Ministry of health of the Russian Federation

Oleynikova N.A.

Lomonosov Moscow State University

Chayka A.V.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Khomyakov V.M.

Herzen Moscow Oncology Research Institute — Branch Campus of the National Medical Radiology Research Center

Kakotkin V.V.

Lomonosov Moscow State University

Yudin M.Yu.

Separate subdivision «SM-Medica» of «SM-Clinic», LLC

Vychuzhanin D.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Andreeva Yu.Yu.

Russian Medical Academy of Continuous Professional Education

Polushkina T.V.

Lomonosov Moscow State University

Received:

18.11.2021

Accepted:

22.12.2021

Close metadata

References:

  1. Uozaki H, Fukayama M. Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms. Int J Clin Exp Pathol. 2008;1(3):198-216. 
  2. Fukayama M, Ushiku T. Epstein-Barr virus-associated gastric carcinoma. Pathol Res Pract. 2011;207(9):529-537.  https://doi.org/10.1016/j.prp.2011.07.004
  3. Shinozaki-Ushiku A, Kunita A, Fukayama M. Update on Epstein-Barr virus and gastric cancer (review). Int J Oncol. 2015; 46(4):1421-1434. https://doi.org/10.3892/ijo.2015.2856
  4. Akiba S, Koriyama C, Herrera-Goepfert R, Eizuru Y. Epstein-Barr virus associated gastric carcinoma: epidemiological and clinicopathological features. Cancer Sci. 2008;99(2):195-201.  https://doi.org/10.1111/j.1349-7006.2007.00674.x
  5. Murphy G, Pfeiffer R, Camargo MC, Rabkin CS. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology. 2009;137(3):824-833.  https://doi.org/10.1053/j.gastro.2009.05.001
  6. The Cancer Genome Atlas (TCGA). Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014; 513(7517):202-209.  https://doi.org/10.1038/nature13480
  7. Rodriquenz MG, Roviello G, D’Angelo A, Lavacchi D, Roviello F, Polom K. MSI and EBV positive gastric cancer’s subgroups and their link with novel immunotherapy. J Clin Med. 2020;9(5):1427. https://doi.org/10.3390/jcm9051427
  8. Camargo MC, Kim KM, Matsuo K, Torres J, Liao LM, Morgan DR, Michel A, Waterboer T, Zabaleta J, Dominguez RL, Yatabe Y, Kim S, Rocha-Guevara ER, Lissowska J, Pawlita M, Rabkin CS. Anti-Helicobacter pylori antibody profiles in Epstein-Barr virus (EBV)-positive and EBV-negative gastric cancer. Helicobacter. 2016;21(2):153-157.  https://doi.org/10.1111/hel.12249
  9. Sun K, Jia K, Lv H, Wang SQ, Wu Y, Lei H, Chen X. EBV-positive gastric cancer: current knowledge and future perspectives. Front Oncol. 2020;10:583463. https://doi.org/10.3389/fonc.2020.583463
  10. Lee JH, Kim SH, Han SH, An JS, Lee ES, Kim YS. Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: a meta-analysis. J Gastroenterol Hepatol. 2009;24(3):354-365.  https://doi.org/10.1111/j.1440-1746.2009.05775.x
  11. Gasenko E, Isajevs S, Camargo MC, Offerhaus GJA, Polaka I, Gulley ML, Skapars R, Sivins A, Kojalo I, Kirsners A, Santare D, Pavlova J, Sjomina O, Liepina E, Tzivian L, Rabkin CS, Leja M. Clinicopathological characteristics of Epstein-Barr virus-positive gastric cancer in Latvia. Eur J Gastroenterol Hepatol. 2019;31(11):1328-1333. https://doi.org/10.1097/MEG.0000000000001521
  12. Gulley ML, Glaser SL, Craig FE, Borowitz M, Mann RB, Shema SJ, Ambinder RF. Guidelines for interpreting EBER in situ hybridization and LMP1 immunohistochemical tests for detecting Epstein-Barr virus in Hodgkin lymphoma. Am J Clin Pathol. 2002;117(2):259-267.  https://doi.org/10.1309/MMAU-0QYH-7BHA-W8C2
  13. Weiss LM, Chen YY. EBER in situ hybridization for Epstein-Barr virus. Methods Mol Biol. (Clifton, NJ). 2013;999:223-230.  https://doi.org/10.1007/978-1-62703-357-2_16
  14. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington MK, Carneiro F, Cree IA. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2019 August. https://doi.org/10.1111/his.13975
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.