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Grebenkin E.N.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Polyanskii M.B.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Perepelevsky A.N.

Ostroverkhov Kursk Oncology Research Clinical Center

Mazalova A.S.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Temirbulatov M.V.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Morphological and molecular genetic features of gastric cancer

Authors:

Grebenkin E.N., Polyanskii M.B., Perepelevsky A.N., Mazalova A.S., Temirbulatov M.V.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2024;13(3): 79‑84

DOI: 10.17116/onkolog20241303179

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To cite this article:

Grebenkin EN, Polyanskii MB, Perepelevsky AN, Mazalova AS, Temirbulatov MV. Morphological and molecular genetic features of gastric cancer. P.A. Herzen Journal of Oncology. 2024;13(3):79‑84. (In Russ.)
https://doi.org/10.17116/onkolog20241303179

Подписка 2025 (P.A. Herzen Journal of Oncology)
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High incidence, poor prognosis, risk of progression after radical surgical treatment, cellular and molecular genetic heterogeneity of gastric cancer represent a serious health problem worldwide; the annual death rate is more than 700.000 cases. Understanding oncogenesis, risk factors, and the use of new approaches to treating this pathology are priority tasks of modern oncology. This review is devoted to modern ideas about carcinogenesis, assessment of the morphologically unchanged gastric mucosa through the prism of the precancerous Correa cascade. The basic molecular mechanisms and signaling pathways of carcinogenesis are described, and the tumor microenvironment is characterized.

Keywords:

gastric cancer
Correa cascade
carcinogenesis
tumor microenvironment
signaling pathways

Authors:

Grebenkin E.N.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Polyanskii M.B.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Perepelevsky A.N.

Ostroverkhov Kursk Oncology Research Clinical Center

Mazalova A.S.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Temirbulatov M.V.

Kursk Oncology Research and Clinical Center named after. G.E. Ostroverkhov

Received:

17.06.2023

Accepted:

18.11.2023

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