Pathogenesis and morphological changes in the lung in COVID-19

Zarubin E.A.; Kogan E.A.

doi:https://doi.org/10.17116/patol20218306154

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Abstract:

The novel coronavirus infection is a rapidly spreading infectious disease that primarily affects the respiratory system and vascular endothelium and has a serious negative impact on healthcare economy and system around the world. To effectively combat the virus, there is a need for a full understanding of the pathogenesis of this infectious disease, and every day there are more and more works that shed light on certain mechanisms of SARS-CoV-2 penetration, replication, and spread. One of these works is studies showing the role of extracellular vesicles (ECVs). The latter are the membrane-enclosed vesicles with a different composition, which are involved in many physiological processes and various diseases, including infectious ones. This review gives the available data on the pathomorphogenesis of COVID-19 and on the possible role of ECVs.

Keywords:

coronavirus infection

coronavirus

COVID-19

SARS-CoV-2

pathogenesis

mechanisms

extracellular vesicles

exosomes

lungs

Authors:

Zarubin E.A.

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Kogan E.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0003-1775-3060

Received:

01.07.2021

Accepted:

17.09.2021

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References:

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