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Salkov V.N.
Scientific Center of Neurology
Khudoyerkov R.M.
Scientific Center of Neurology
The role of aluminum and lead in the development of Alzheimer’s and Parkinson’s diseases
Journal: Russian Journal of Archive of Pathology. 2021;83(3): 56‑61
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To cite this article:
Salkov VN, Khudoyerkov RM. The role of aluminum and lead in the development of Alzheimer’s and Parkinson’s diseases. Russian Journal of Archive of Pathology.
2021;83(3):56‑61. (In Russ.)
https://doi.org/10.17116/patol20218303156
The article summarizes the data available in the literature on the toxic effects of aluminum and lead on the human brain and assesses the relationship of these effects to the etiopathogenesis of the most common neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. The accumulation of ions of these metals in the brain structures leads to chronic intoxication that is manifested by the morphological signs that are typical for Alzheimer’s disease, such as deposits of β-amyloid and τ-protein mainly in the frontal and temporal regions of the cortex, and for Parkinson’s disease, such as degeneration of dopamine neurons in the substantia nigra and their accumulation of α-synuclein. The most likely forms of participation of aluminum and lead ions in the mechanisms of neurodegeneration are the replacement of bivalent metal ions necessary for brain functioning, oxidative stress initiation, epigenetic modifications of histones, and increased expression of noncoding ribonucleic acids.
Authors:
Salkov V.N.
Scientific Center of Neurology
Khudoyerkov R.M.
Scientific Center of Neurology
Received:
26.01.2021
Accepted:
05.03.2021
List of references:
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