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Kogan E.A.

Sechenov First Moscow State Medical University

Berezovsky Yu.S.

Central Research Institute of Tuberculosis

Kukleva A.D.

Sechenov First Moscow State Medical University

Kurilina E.V.

Myasnikov National Medical Research Center of Cardiology

Semenova L.A.

Central Research Institute of Tuberculosis

Blagova O.V.

Sechenov First Moscow State Medical University

Zharkov N.V.

Sechenov First Moscow State Medical University

Lymphocytic myocarditis in patients with COVID-19 (4 autopsy cases)

Authors:

Kogan E.A., Berezovsky Yu.S., Kukleva A.D., Kurilina E.V., Semenova L.A., Blagova O.V., Zharkov N.V.

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Journal: Russian Journal of Archive of Pathology. 2020;82(5): 57‑62

DOI: 10.17116/patol20208205157

Views: 3444

Downloaded: 163

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To cite this article:

Kogan EA, Berezovsky YuS, Kukleva AD, Kurilina EV, Semenova LA, Blagova OV, Zharkov NV. Lymphocytic myocarditis in patients with COVID-19 (4 autopsy cases). Russian Journal of Archive of Pathology. 2020;82(5):57‑62. (In Russ.)
https://doi.org/10.17116/patol20208205157

Подписка 2025 (Russian Journal of Archive of Pathology)
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The paper describes 4 autopsy cases of myocarditis in elderly patients with confirmed coronavirus infection. It gives the data of a morphological study of heart specimens and a detailed characterization of a myocardial infiltrate. An immunohistochemical study with cellular infiltrate typing was performed. The fact that lymphocytic viral myocarditis can develop in COVID-19 was morphologically and immunohistochemically confirmed. The features of myocarditis in COVID-19 are the development of the former in the presence of coronaritis and the possibility of its concurrence with lymphocytic endo- and pericarditis.

Keywords:

COVID-19
SARS-CoV-2
coronavirus
ACE-2
myocarditis
endocarditis
CD3 T lymphocytes
perforin
TLR-4
TLR-9

Authors:

Kogan E.A.

Sechenov First Moscow State Medical University

Berezovsky Yu.S.

Central Research Institute of Tuberculosis

Kukleva A.D.

Sechenov First Moscow State Medical University

Kurilina E.V.

Myasnikov National Medical Research Center of Cardiology

Semenova L.A.

Central Research Institute of Tuberculosis

Blagova O.V.

Sechenov First Moscow State Medical University

Zharkov N.V.

Sechenov First Moscow State Medical University

Received:

03.06.2020

Accepted:

10.07.2020

List of references:

  1. Chen C, Zhou Y, Wang DW. SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz. 2020;45(3):230-232.  https://doi.org/10.1007/s00059-020-04909-z
  2. Hanff TC, Harhay MO, Brown TS, Sbrown T, Mohareb AM. Is there an association between COVID-19 mortality and the renin-angiotensin system? A call for epidemiologic investigations. Clin Infect Dis. 2020;ciaa329. https://doi.org/10.1093/cid/ciaa329
  3. Su S, Wong G, Shi W, Liu J, Lai ACK, Zhou J, Liu W, Bi Y, Gao GF. Epidemiology, genetic recombination, and pathogenesis of coronaviruses. Trends Microbiol. 2016;24(6):490-502.  https://doi.org/10.1016/j.tim.2016.03.003
  4. Lai M, et al. Coronaviridae. In: Knipe DM, Howley PM, eds. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007.
  5. Bansal M. Cardiovascular disease and COVID-19. Diabetes Metab Syndr. 2020;14(3):247-250.  https://doi.org/10.1016/j.dsx.2020.03.013
  6. Guzik TJ, Mohiddin SA, Dimarco A, Patel V, Savvatis K, Marelli-Berg FM, Madhur MS, Tomaszewski M, Maffia P, D’Acquisto F, et al. COVID-19 and the cardiovascular system implications for risk assessment, diagnosis, and treatment options. Cardiovasc Res. 2020;cvaa106. https://doi.org/10.1093/cvr/cvaa106
  7. Xiong TY, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: acute and long-term implications. Eur Heart J. 2020;41(19):1798-1800. https://doi.org/10.1093/eurheartj/ehaa231
  8. Kochi AN, Tagliari AP, Forleo GB, Fassini GM, Tondo C. Cardiac and arrhythmic complications in patients with COVID‐19. J Cardiovasc Electrophysiol. 2020;31(5):1003-1008. https://doi.org/10.1111/jce.14479
  9. Mahmud E, Dauerman HL, Welt FG, Messenger JC, Rao SV, Grines C, Mattu A, Kirtane AJ, Jauhar R, Meraj P, Rokos IC, Rumsfeld JS, Henry TD. Management of acute myocardial infarction during the COVID-19 pandemic. J Am Coll Cardiol. 2020;S0735-1097(20)35026-9.  https://doi.org/10.1016/j.jacc.2020.04.039
  10. Sala S, Peretto G, Gramegna M, Palmisano A, Villatore A, Vignale D, De Cobelli F, Tresoldi M, Cappelletti AM, Basso C, Godino C, Esposito A. Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection. Eur Heart J. 2020;41(19):1861-1862. https://doi.org/10.1093/eurheartj/ehaa286

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