Features of the development of latent autoimmune diabetes in adults (LADA) (in Russian only)

Timakova A.A.; Saltykov B.B.

doi:https://doi.org/10.17116/patol20198104178

Timakova A.A.

Akad. A.I. Strukov Department of Pathologic Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Saltykov B.B.

Department of pathological anatomy, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russia, Moscow, Russia

Features of the development of latent autoimmune diabetes in adults (LADA) (in Russian only)

Authors:

Timakova A.A., Saltykov B.B.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2019;81(4): 78‑82

DOI: 10.17116/patol20198104178

Read: 34270 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Timakova AA, Saltykov BB. Features of the development of latent autoimmune diabetes in adults (LADA) (in Russian only). Russian Journal of Archive of Pathology. 2019;81(4):78‑82. (In Russ.)
https://doi.org/10.17116/patol20198104178

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Liver pathology in COVID-19. Russian Journal of Archive of Pathology. 2025;(1):53-59

Pathogenesis of fibrosis development in ovarian endometriosis. Russian Journal of Archive of Pathology. 2025;(2):73-78

Solitary fibrous tumor of the kidney. Russian Journal of Archive of Pathology. 2025;(3):77-81

Mystery of the illness of the great painter I. Repin. By the 180th anniversary. Burdenko's Journal of Neurosurgery. 2025;(1):6-10

Infectious factors in atopic dermatitis, pharmaceutical possibilities (systematic literature review). Russian Journal of Clinical Dermatology and Venereology. 2025;(1):7-15

A modern perspective on the pathogenesis of proliferative diabetic retinopathy. Russian Annals of Ophthalmology. 2025;(1):92-98

Scanning electron microscopy in hemotology. Laboratory Service. 2025;(1):38-47

Epidemiology of M. genitalium infection. What is known?. Russian Journal of Clinical Dermatology and Venereology. 2025;(2):143-152

Portopulmonary hypertension. Journal of Respiratory Medicine. 2025;(2):39-44

Morphological assessment of early and delayed reparative processes of the mucous membrane in the localization of laser and traditional rhinoanthrostomes. Russian Bulletin of Otorhinolaryngology. 2025;(3):40-45

Abstract:

The study of the sociomedical problems of diabetes mellitus led to the discovery of latent autoimmune diabetes in adults (LADA), a special form of the disease. The slow onset of the disease, the clinical signs of type 2 diabetes mellitus concurrent with the autoantibody pancreatic β-cell destruction mechanism that is characteristic of type 1 diabetes. Genetic factors play an important role in the genesis of the disease. Insulitis concurrent with intact or hypertrophic islets of the gland originally develops morphologically. Subsequently, the phenomena of islet atrophy and sclerosis are progressive. The disease is typical for young people (generally those aged 25—35 years) with normal body mass index, low blood C-peptide levels, with antibodies against β-cells, primarily to glutamate decarboxylase, being detected. Insulin preparations should be used to treat these patients.

Keywords:

latent autoimmune diabetes in adults

ethiology

pathogenesis

morphology

Authors:

Timakova A.A.

Akad. A.I. Strukov Department of Pathologic Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Saltykov B.B.

Close metadata

References:

Ametov AS. Sakharnyi diabet 2-go tipa. Problemy i resheniya. 3rd ed. Moscow: GEOTAR-Media; 2018;9. (In Russ.)
Antsiferov MB (ed.). Sovremennye aspekty farmakoterapii endokrinnykh zabolevanii. Moscow: Bionika Media, 2018. (In Russ.)
Dedov II, Shestakova MV, Kuraeva TL, Titovich EV, Nikonova TV. Nozological heterogeneity, molecular genetics and immunology of autoimmune diabetes mellitus. Vestnik Rossiiskoi akademii meditsinskikh nauk. 2015;70(2):132-138. (In Russ.) https://doi.org/10.15690/vramn.v70i2.1305
Dedov II, Shestakova MV, ed. Sakharnyi diabet: mnogoobrazie klinicheskikh form. Moscow: MIA; 2016. (In Russ.)
Kumar A, De Leiva A. Latent autoimmune diabetes in adults (LADA): the prevalent form of adult-onset autoimmune diabetes in a region of India. J Endocrinol Diabet. 2017;4(3):1-6. https://doi.org/10.15226/2374680/4/3/00180
Zimmet P, Turner R, McCarty D, et al. Cit. po I.I. Dedov I.I., M.V. Shestakova M.V., 2016. [4].
Hjort R, Alfredsson L, Andersson T, Carlsson PO, Grill V, Groop L, Martinell M, Rasouli B, Storm P, Tuomi T, Carlsson S. Family history of type 1 and type 2 diabetes and risk of latent autoimmune diabetes in adults (LADA). Diabetes Metab. 2017;43(6):536-542. https://doi.org/10.1016/j.diabet.2017.05.010
Hjort R, Alfredsson L, Carlsson PO, Groop L, Martinell M, Storm P, Tuomi T, Carlsson S. Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case–control study. Diabetologia. 2015;58(11):2525-2532. https://doi.org/10.1007/s00125-015-3711-8
Hjort R, Ahlqvist E, Carlsson PO, Grill V, Groop L, Martinell M, Rasouli B, Rosengren A, Tuomi T, Åsvold BO, Carlsson S. Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study. Diabetologia. 2018;61(6):1333-1343. https://doi.org/10.1007/s00125-018-4596-0
Rasouli B, Andersson T, Carlsson PO, Grill V, Groop L, Martinell M, Storm P, Tuomi T, Carlsson S. Smoking and the risk of LADA: results from a Swedish population-based case-control study. Diabetes Care. 2016;39(5):794-800. https://doi.org/10.2337/dc15-2348
Rasouli B, Grill V, Midthjell K, Ahlbom A, Andersson T, Carlsson S. Smoking is associated with reduced risk of autoimmune diabetes in adults contrasting with increased risk in overweight men with type 2 diabetes: A 22-year follow-up of the HUNT study. Diabetes Care. 2012;36(3):604-610. https://doi.org/10.2337/dc12-0913
Rasouli B, Andersson T, Carlsson PO, Grill V, Groop L, Martinell M, Midthjell K, Storm P, Tuomi T, Carlsson S. Use of Swedish smokeless tobacco (snus) and the risk of Type 2 diabetes and latent autoimmune diabetes of adulthood (LADA). Diabet Med. 2016;34(4):514-521. https://doi.org/10.1111/dme.13179
Carlsson S. Environmental (lifestyle) risk factors for LADA. Curr Diabetes Rev. 2018; Jul 16.
Rasouli B, Ahlqvist E, Alfredsson L, Andersson T, Carlsson PO, Groop L, Löfvenborg JE, Martinell M, Rosengren A, Tuomi T, Wolk A, Carlsson S. Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults: A population-based case-control study. Diabetes Metab. 2018;44(4):354-360. https://doi.org/10.1016/j.diabet.2018.05.002
Yau M, Maclaren NK, Sperling M. Etiology and pathogenesis of diabetes mellitus in children and adolescents. Endotext. 2018 February 13.
Löfvenborg JE, Andersson T, Carlsson PO, Dorkhan M, Groop L, Martinell M, Tuomi T, Wolk A, Carlsson S. Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Eur J Endocrinol. 2016;175(6):605-614. https://doi.org/10.1530/EJE-16-0376
Rasouli B, Andersson T, Carlsson PO, Hjort R, Löfvenborg JE, Martinell M, Groop L, Tuomi T, Carlsson S. Serious life events and the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Diabet Med. 2017;34(9):1259-1263. https://doi.org/10.1111/dme.13410
Chen YL, Qiao YC, Song XN, Ling W, Zhao HL, Zhang XX. Emotional exhaustion-induced latent autoimmune diabetes in adults in a young lady. Medicine (Baltimore). 2017;96(20):e6915. https://doi.org/10.1097/MD.0000000000006915
Rasouli B, Andersson T, Carlsson PO, Dorkhan M, Grill V, Groop L, Martinell M, Tuomi T, Carlsson S. Alcohol and the risk for latent autoimmune diabetes in adults: results based on Swedish ESTRID study. Eur J Endocrinol. 2014;171(5):535-543. https://doi.org/10.1530/EJE-14-0403
Rasouli B. Alcohol, tobacco and the risk of LADA-latent autoimmune diabetes in adults. Stockholm: Karolinska Institutet, 2016.
Luo S, Lin J, Xie Z, Xiang Y, Zheng P, Huang G, Li X, Liao Y, Hagopian WA, Wang CY, Zhou Z.J. HLA Genetic discrepancy between latent autoimmune diabetes in adults and type 1 diabetes: LADA China Study No. 6. J Clin Endocrinol Metab. 2016;101(4):1693-1700. https://doi.org/10.1210/jc.2015-3771
Silko YuV, Nikonova TV, Ivanova ON, Stepanova SM, Shestakova MV, Dedov II. Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA). Sakharnyi diabet. 2016;19(3):199-203. (In Russ.) https://doi.org/10.14341/DM2003418-21
Zhang N, Huang W, Dong F, Liu Y, Zhang B, Jing L, Wang M, Yang G, Jing C. Insulin gene VNTR polymorphisms –2221MspI and –23HphI are associated with type 1 diabetes and latent autoimmune diabetes in adults: a metaanalysis. Acta Diabetol. 2015;52(6):1143-1155. https://doi.org/10.1007/s00592-015-0805-1
Pes GM, Delitala AP, Errigo A, Delitala G, Dore MP. Clustering of immunological, metabolic and genetic features in latent autoimmune diabetes in adults: evidence from principal component analysis. Intern Emerg Med. 2016;11(4):561-567. https://doi.org/10.1007/s11739-015-1352-z
Hou C, Zhong Y, Wang Z, Ming Z, Huang G, Ouyang L, Li Y, Lu Q, Zhou Z. STAT3-mediated epigenetic silencing of FOXP3 in LADA T-cells is regulated through HDAC5 and DNMT1. Clin Immunol. 2018;191:116-125. https://doi.org/10.1016/j.clim.2017.12.001
Pekareva EV, Nikonova TV, Gorelysheva VA, Prokof’ev SA, Zvereva YaS, Stepanova SM, Smirnova OM. Markers of apoptosis in patients with type 1 diabetes mellitus at the onset of the disease. Sakharnyy diabet. 2009;4:73-89. (In Russ.)
Deng C, Xiang Y, Tan T, Ren Z, Cao C, Huang G, Wen L, Zhou Z. Altered peripheral B-lymphocyte subsets in type 1 diabetes and latent autoimmune diabetes in adults. Diabetes Care. 2016;39(3):434-440. https://doi.org/10.2337/dc15-1765
Kronenberg GM, Melmed Sh, Polonsky ES, Larsen PR. Williams textbook of endocrinology. Moscow: GEOTAR-Media; 2010. (In Russ.)
Lu J, Hou X, Pang C, Zhang L, Hu C, Zhao J, Bao Y, Jia W. Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults. Diabetes Metab Res Rev. 2016;32(8):858-866. https://doi.org/10.1002/dmrr.2806
Towns R, Pietropaolo M. GAD65 autoantibodies and its role as biomarker of type 1 diabetes and latent autoimmune diabetes in adults (LADA). Drugs Future. 2011;36(11):847.
Castelblanco E, Hernández M, Castelblanco A, Gratacòs M, Esquerda A, Molló À, Ramírez-Morros A, Real J, Franch-Nadal J, Fernández-Real JM, Mauricio D. Low-grade inflammatory marker profile may help to differentiate patients with LADA, classic adult-onset type 1 diabetes, and type 2 diabetes. Diabetes Care. 2018;41(4):862-868. https://doi.org/10.2337/dc17-1662
Hakethal V. LADA: time to update diabetes classification? 2017 January 5.
Silko YuV, Nikonova TV, Shestakova MV. Incretins role in Latent autoimmune diabetes of adults pathogenesis, the possibility of therapy with combination of glucagon-like peptide-1 agonist (GLP-1) and insulin. Ozhirenie i metabolizm. 2016;13(2):3-6. (In Russ.)