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Dvoryanchikov V.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Ryazantsev S.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Krivopalov A.A.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech;
I.I. Mechnikov North-Western State Medical University
Alekseenko S.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech;
I.I. Mechnikov North-Western State Medical University;
K.A. Raukhfus Children’s City Multidisciplinary Clinical Center of High Medical Technologies
Barashkova S.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech;
K.A. Raukhfus Children’s City Multidisciplinary Clinical Center of High Medical Technologies;
National Center for Clinical Morphological Diagnostics
Turieva V.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Evaluation of therapeutic efficiency of the combined nasal spray containing hyaluronic acid and alpha-tocopherol in postoperative period after endonasal surgery
Journal: Russian Rhinology. 2024;32(4): 283‑295
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To cite this article:
Dvoryanchikov VV, Yanov YuK, Ryazantsev SV, Krivopalov AA, Alekseenko S, Barashkova SV, Turieva VV. Evaluation of therapeutic efficiency of the combined nasal spray containing hyaluronic acid and alpha-tocopherol in postoperative period after endonasal surgery. Russian Rhinology.
2024;32(4):283‑295. (In Russ.)
https://doi.org/10.17116/rosrino202432041283
To study the impact of combined nasal spray containing hyaluronic acid and alpha-tocopherol on the dynamics of complaints, signs of synonasal pathology after elective endoscopic endonasal interventions in the nasal cavity and paranasal sinuses.
The study included 40 adults and adolescents (age 16—55 years) and 40 children (3—15 years), divided into 2 groups (20 adults and 20 children in each). Patients of the comparison group received standard therapy in the postoperative period; patients of the study group — standard therapy, which included an intranasally administered nasal spray containing hyaluronic acid and alpha-tocopherol (Olyfrin, Solopharm, Russia). Patients’ complaints were evaluated using a visual analogue scale before the surgery (visit 1), as well as 6—7 (visit 2) and 28—30 (visit 3) days after the intervention. The study of the mucociliary clearance function was performed using the method of videocytomorphometry.
There has been no significant reduction in the severity of complaints and pathology’s signs in patients of the comparison group, whereas a significant decrease in the values of these indicators has been observed with the use of combined nasal spray in the visit 2. There has been a significant decrease in the severity of complaints and signs of synonasal pathology by the end of observation (visit 3) in both groups, but values of this indicators were significantly lower in the group using nasal spray than in the comparison group.
Olyfrin combined nasal spray containing hyaluronic acid and alpha-tocopherol can be considered as an effective treatment component after endonasal surgery.
Keywords:
Authors:
Dvoryanchikov V.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Ryazantsev S.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Krivopalov A.A.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech;
I.I. Mechnikov North-Western State Medical University
Alekseenko S.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech;
I.I. Mechnikov North-Western State Medical University;
K.A. Raukhfus Children’s City Multidisciplinary Clinical Center of High Medical Technologies
Barashkova S.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech;
K.A. Raukhfus Children’s City Multidisciplinary Clinical Center of High Medical Technologies;
National Center for Clinical Morphological Diagnostics
Turieva V.V.
St. Petersburg Research Institute of Ear, Throat, Nose and Speech
Received:
13.09.2024
Accepted:
02.10.2024
List of references:
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