Epstein—Barr virus-associated gastric adenocarcinoma (in Russian only)

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EBV-associated gastric adenocarcinoma accounts for 10% of all gastric adenocarcinomas. The main known facts about the pathogenesis of EBV-associated gastric adenocarcinoma are presented. There are two main morphological types: gastric carcinoma with lymphoid stroma — GCLS (including lymphoepithelioma-like carcinoma; carcinoma with Crohn’s disease-like lymphoid reaction; EBV-associated carcinoma with osteoclast-like giant cells) and conventional type adenocarcinoma. EBV-associated gastric adenocarcinomas predominantly express markers of gastric differentiation (MUC5AC, MUC6, CLDN-18) and a number of viral markers (EBER-1, EBNA-1 and BART mRNA). Three types of EBV latent cycle depending on the set of expressed viral transcripts are distinguished. It is believed that EBV-associated gastric adenocarcinoma is characterized by an intermediate position between latent cycles of types 1 and 2. The main method of virus identification is in situ hybridization with the detection of Epstein—Barr virus-encoded small RNAs (EBER-ISH).

Keywords:

Epstein—Barr virus

gastric cancer

carcinogenesis

latency

latent genes

Authors:

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Mal'kov P.G.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Oleynikova N.А.

Lomonosov Moscow State University, Moscow, Russia

Mikhailov I.A.

Lomonosov Moscow State University

SPIN RSCI: 5798-0749
Scopus AuthorID: 57203900904
ResearcherID: I-9035-2017
ORCID: 0000-0001-8020-369X

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