An expert system for differential diagnosis of medullary and oxyphilic cell thyroid carcinoma

Kirillov V.A.; Emel'ianova O.A.; Gladyshev A.O.

doi:https://doi.org/

Kirillov V.A.

Laboratoriia PR-dozimetrii i tsitologii Belorusskogo gosudarstvennogo meditsinskogo universiteta, Minsk, Belarus'

Emel'ianova O.A.

Laboratoriia PR-dozimetrii i tsitologii Belorusskogo gosudarstvennogo meditsinskogo universiteta, Minsk, Belarus'

Gladyshev A.O.

Laboratoriia PR-dozimetrii i tsitologii Belorusskogo gosudarstvennogo meditsinskogo universiteta, Minsk, Belarus'

An expert system for differential diagnosis of medullary and oxyphilic cell thyroid carcinoma

Authors:

Kirillov V.A., Emel'ianova O.A., Gladyshev A.O.

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Journal: Russian Journal of Archive of Pathology. 2014;76(5): 26‑32

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To cite this article:

Kirillov VA, Emel'ianova OA, Gladyshev AO. An expert system for differential diagnosis of medullary and oxyphilic cell thyroid carcinoma. Russian Journal of Archive of Pathology. 2014;76(5):26‑32. (In Russ.)

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

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Abstract:

Objective - to reveal the quantitative regularities of pathological changes in the nuclei and aggregates of C and B cells and to build an expert system on their basis for the differential diagnosis of medullary and oxyphilic cell thyroid carcinoma. Material and methods. Puncture smears with histologically verified medullary (C cell) carcinoma and oxyphilic cell (B cell) carcinoma were investigated. The nuclei and aggregates of C cells and B cells (Hürthle cells, oncocytes) were morphometrically examined with a computer color image analyzer on the basis of a light microscope and a digital photo camera. Results. The quantitative regularities of the degree of C and B cell aggregation in medullary and oxyphilic cell thyroid carcinoma were found by morphometry. The threshold values for the aggregates in the comparison groups and their weight coefficients formed the basis for the expert system to differentially diagnose medullary and oxyphilic cell carcinoma at the initial stages of patient examination. The clinical trials showed the high efficiency of the developed expert system.

Keywords:

medullary carcinoma

oxyphilic cell carcinoma

morphometry

expert system

diagnosis

Authors:

Kirillov V.A.

Laboratoriia PR-dozimetrii i tsitologii Belorusskogo gosudarstvennogo meditsinskogo universiteta, Minsk, Belarus'

Emel'ianova O.A.

Laboratoriia PR-dozimetrii i tsitologii Belorusskogo gosudarstvennogo meditsinskogo universiteta, Minsk, Belarus'

Gladyshev A.O.

Laboratoriia PR-dozimetrii i tsitologii Belorusskogo gosudarstvennogo meditsinskogo universiteta, Minsk, Belarus'

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References:

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