Features of peroxide-antioxidant imbalance in patients with rosacea and approaches to comprehensive therapy

Ayupova K.R.; Yusupova L.A.

doi:https://doi.org/10.17116/klinderma202524041439

Ayupova K.R.

Kazan State Medical Academy

ORCID: 0000-0002-2179-1214

Yusupova L.A.

Kazan State Medical Academy

ORCID: 0000-0001-8937-2158

Features of peroxide-antioxidant imbalance in patients with rosacea and approaches to comprehensive therapy

Authors:

Ayupova K.R., Yusupova L.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2025;24(4): 439‑444

DOI: 10.17116/klinderma202524041439

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To cite this article:

Ayupova KR, Yusupova LA. Features of peroxide-antioxidant imbalance in patients with rosacea and approaches to comprehensive therapy. Russian Journal of Clinical Dermatology and Venereology. 2025;24(4):439‑444. (In Russ.)
https://doi.org/10.17116/klinderma202524041439

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

Использование инфографики авторами научных работ

BACKGROUND

Rosacea is induced after repeated exposure to triggering, damaging factors. A comprehensive approach that includes an antioxidant can improve the quality of life of patients with rosacea.

OBJECTIVE

To study the indicators of peroxide-antioxidant body’s state and the efficacy of comprehensive therapy with inclusion of ethylmethylhydroxypyridine malate (EMHPM) in patients with rosacea.

MATERIAL AND METHODS

Patients with papulopustular rosacea (n=38) were distributed as follows: 19 were treated with baseline therapy and 19 additionally received EMHPM at a dose of 100 mg three times a day during the month. Patients with rosacea underwent a blood serum sampling with determination of parameters of ceruloplasmin, glutathione peroxidase in erythrocytes, lipid peroxidation, superoxide dismutase, malonyldialdehyde, as well as the dynamics of indicators on the scales of diagnostic assessment of rosacea, global evaluation of researcher’s effectiveness, dermatological life quality index was analyzed.

RESULTS

In the study of oxidative stress state and antioxidant protection in patients with rosacea, it has been revealed that the concentration of superoxide dismutase was statistically significantly reduced (p<0.001) in presence of an increase in the malonyldialdehyde (p<0.001) in moderate severity. The course of therapy with EMHPM has contributed to a significant decrease in glutathione peroxidase level in erythrocytes by 39.95% (p<0.001).

CONCLUSION

It has been found that the inclusion of EMHPM in comprehensive therapy for patients with rosacea contributed to normalization of indicators of lipid peroxidation, ceruloplasmin, superoxide dismutase compared to healthy individuals (p<0.001), decrease in the value on the scale of rosacea diagnostic assessment by 2.6 times and dermatological life quality index by 3.8 times.

Keywords:

rosacea

papulopustular subtype

ethylmethylhydroxypyridine malate

diagnosis

treatment

Authors:

Ayupova K.R.

Kazan State Medical Academy

ORCID: 0000-0002-2179-1214

Yusupova L.A.

Kazan State Medical Academy

ORCID: 0000-0001-8937-2158

Received:

03.08.2024

Accepted:

20.05.2025

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References:

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