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Leyderman I.N.

Almazov National Medical Research Center, St. Petersburg, Russia

Potapov A.L.

A.F. Tsyb MRNC, branch of FGBU “NMC of Radiology”, Obninsk, Russia

Pasechnik I.N.

Central State Medical Academy of the Presidential Executive Office of the Russian Federation, Moscow, Russia

Zabolotskikh I.B.

Kuban State Medical University, Krasnodar, Russia

Kokarev E.A.

Primorsky Regional Clinical Hospital No. 1, Vladivostok, Russia

Lebedinskii K.M.

Mechnikov North-Western State Medical University, St. Petersburg, Russia

Orlov Yu.P.

Omsk State Medical University, Omsk, Russia

Petrova M.V.

RUDN University, Moscow, Russia

Ryk A.A.

N.V. Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia

Sviridov S.V.

Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia

Strukov E.Yu.

Military Medical Academy, St. Petersburg, Russia

Sytov A.V.

N.N. Blokhin Oncology Research Center, Moscow, Russia

Tsvetkov D.S.

Dolgoprudenskaya Hospital, Moscow, Russia

Shen N.P.

Tyumen State Medical University, Tyumen, Russia

Shestopalov A.E.

Federal Scientific and Clinical Center of Reanimatology and Rehabilitation, Moscow, Russia

Yaroshetskiy A.I.

Sechenov First Moscow State Medical University, Moscow, Russia

Perioperative nutritional support. Guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists”

Authors:

Leyderman I.N., Potapov A.L., Pasechnik I.N., Zabolotskikh I.B., Kokarev E.A., Lebedinskii K.M., Orlov Yu.P., Petrova M.V., Ryk A.A., Sviridov S.V., Strukov E.Yu., Sytov A.V., Tsvetkov D.S., Shen N.P., Shestopalov A.E., Yaroshetskiy A.I.

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To cite this article:

Leyderman IN, Potapov AL, Pasechnik IN, et al. Perioperative nutritional support. Guidelines of the All-Russian public organization “Federation of Anesthesiologists and Reanimatologists”. Russian Journal of Anesthesiology and Reanimatology. 2026;(4):6‑25. (In Russ.)
https://doi.org/10.17116/anaesthesiology20260416

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References:

  1. Lederman IN, Grican AI, Zabolotskih IB, et al. Perioperacionnaya nutritivnaya podderzhka. Metodicheskie rekomendacii Federacii anesteziologov i reanimatologov. Vestnik intensivnoj terapii im. A.I. Saltanova. 2021;4:7-20. (In Russ.). https://doi.org/10.21320/1818-474X-2021-4-7-20
  2. Cederholm T, Barazzoni R, Austin P, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64.  https://doi.org/10.1016/j.clnu.2016.09.004
  3. Weimann A, Bezmarevic M, Braga M, Correia MITD, Funk-Debleds P, Gianotti L, Gillis C, Hübner M, Inciong JFB, Jahit MS, Klek S, Kori T, Laviano A, Ljungqvist O, Lobo DN, Segurola CL, Montroni I, Reddy BR, Saur NM, Schweinlin A, Shi HP, Takeuchi H, Waitzberg DL, Wallengren O, Wischmeyer PE, Ysebaert D, Bischoff SC. ESPEN guideline on clinical nutrition in surgery — Update 2025. Clin Nutr. 2025;53:222-261.  https://doi.org/10.1016/j.clnu.2025.08.029
  4. Wu Y, Liu R-T, Zhou X-Y, Fang Q, Huang D, Jia Z-Y. The Global Leadership Initiative on Malnutrition criteria for diagnosis of malnutrition and outcomes prediction in emergency abdominal surgery. Nutrition. 2024;119:112298. https://doi.org/10.1016/j.nut.2023.112298
  5. Eminovic S, Vincze G, Eglseer D, Riedl R, Sadoghi P, Leithner A, Bernhardt GA. Malnutrition as predictor of poor outcome after total hip arthroplasty. Int Orthop. 2021;45(1):51-56.  https://doi.org/10.1007/s00264-020-04892-4
  6. Gee R, Haurin K, Saxena A, DiSantis KI. The impact of nutritional status on surgical site infection rates among total joint arthroplasty patients: A systematic review. Am J Infect Control. 2025;S0196-6553(25)00527-9.  https://doi.org/10.1016/j.ajic.2025.08.015
  7. Zang Y, Xu W, Qiu Y, Gong D, Fan Y. Association between Risk of Malnutrition Defined by the Nutritional Risk Screening 2002 and Postoperative Complications and Overall Survival in Patients with Cancer: A Meta-Analysis. Nutr Cancer. 2023;75(8):1600-1609. https://doi.org/10.1080/01635581.2023.2227402
  8. Hu Y, Wang L, Liu H, Yang K, Wang S, Zhang X, Qu B, Yang H. Association of preoperative hypoprotein malnutrition with spinal postoperative complications and other conditions: A systematic review and meta-analysis. Clin Nutr ESPEN. 2023;57:448-458.  https://doi.org/10.1016/j.clnesp.2023.07.083
  9. Kazemian S, Tavolinejad H, Rashedi S, Yarahmadi P, Farrokhpour H, Kolte D. Meta-Analysis on the Association Between Nutritional Status and Outcomes After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2023;186:109-116.  https://doi.org/10.1016/j.amjcard.2022.10.016
  10. Dong M, Cheng J, Gong L, Xiao Y, Shao S, Song J. Malnutrition Predicts Adverse Outcomes After Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. Anatol J Cardiol. 2023;27(5):240-248.  https://doi.org/10.14744/AnatolJCardiol.2023.2710
  11. Cheung HHT, Joynt GM, Lee A. Diagnostic test accuracy of preoperative nutritional screening tools in adults for malnutrition: a systematic review and network meta-analysis. Int J Surg. 2024;110(2):1090-1098. https://doi.org/10.1097/JS9.0000000000000845
  12. Petra G, Kritsotakis EI, Gouvas N, Schizas D, Toutouzas K, Karanikas M, Pappas-Gogos G, Stylianidis G, Zacharioudakis G, Laliotis A, Christodoulidis G, Kehagias I, Lasithiotakis K. Multicentre prospective study on the diagnostic and prognostic validity of malnutrition assessment tools in surgery. Br J Surg. 2025;112(2):znaf013. https://doi.org/10.1093/bjs/znaf013
  13. Jensen GL, Cederholm T, Correia MITD, et al. GLIM Criteria for the Diagnosis of Malnutrition: A Consensus Report From the Global Clinical Nutrition Community. J Parenter Enteral Nutr. 2019;43(1):32-40.  https://doi.org/10.1002/jpen.1440
  14. Lidoriki I, Frountzas M, Mela E, Papaconstantinou D, et al. The Prognostic Role of GLIM Criteria in Postoperative Outcomes after Upper Gastrointestinal Cancer Surgery: A Meta-Analysis of Observational Studies. Nutr Cancer. 2023;75(2):640-651.  https://doi.org/10.1080/01635581.2022.2146144
  15. Ashmore DL, Rashid A, Wilson TR, Halliday V, Lee MJ. Identifying malnutrition in emergency general surgery: systematic review. BJS Open. 2023; 7(5):zrad086. https://doi.org/10.1093/bjsopen/zrad086
  16. Leyderman IN, Kokarev EA, Efremov SM, Astahov AA, Bel'skij DV, Bogdanov RR, Vashukova EYu, Voevodin SV, Govorova NV, Gorbachev VI, Gorohovskij VS, Dorozhkin AD, Ershov VI, Zhukov AV, Zybin KD, Kanshaov NZ, Kirov MYu, Kosteckij IV, Krylov KYu, Kuznecov SV, Lesteva NA, Lobov OA, Luft VM, Medvedev AYu, Nejmark MI, Nelyubin AG, Parmenov AE, Petrova MV, Potapov AL, Pylaev AV, Rublev VYu, Ruslyakova IA, Ryk AA, Saetgaraev AK, Samatov IYu, Sviridov SV, Sivkov AO, Smirnov MV, Sorokin EP, Simutis IS, Strukov EYu, Sytov AV, Fisher VV, Horoshilov IE, Cvetkov DS, Cybin NV, SHakot'ko AP, Shen' NP, Shestopalov AE, Shukevich DL, Engaus RE, Yakovlev AYu, Yarosheckij AI, Zabolotskih IB. Tekhnologii nutritivnoj podderzhki i metabolicheskogo kontrolyav otdeleniyah reanimacii i intensivnoj terapii. Rezul'taty mnogocentrovogo prospektivnogo skriningovogo issledovaniya. Vestnik intensivnoj terapii imeni AI. Saltanova. 2025;3:162-180. (In Russ.). https://doi.org/10.21320/1818-474X-2025-3-162-180
  17. Singer P, Blaser AR, Berger MM. ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit. Clin Nutr. 2023; 42(9):1671-1689. https://doi.org/10.1016/j.clnu.2023.07.011
  18. Díaz G, Correia MITD, Gonzalez MC, Reyes M. The global leadership initiative on malnutrition criteria for the diagnosis of malnutrition in patients admitted to the intensive care unit: A systematic review and meta-analysis. Clin Nutr. 2023;42(2):182-189.  https://doi.org/10.1016/j.clnu.2022.12.007
  19. Sivkov AO, Lejderman IN, Sivkov OG. Markery nutritivnoj nedostatochnosti — prediktory neblagopriyatnogo klinicheskogo iskhoda u pacientov v kriticheskom sostoyanii na dlitel'noj iskusstvennoj ventilyacii legkih. Anesteziologiya i reanimatologiya. 2022;6:52-57. (In Russ.). https://doi.org/10.17116/anaesthesiology202206152
  20. Saur NM, Davis BR, Montroni I, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Perioperative Evaluation and Management of Frailty Among Older Adults Undergoing Colorectal Surgery. Dis Colon Rectum. 2022 Apr 01;65(4):473-488.  https://doi.org/10.1097/DCR.0000000000002410
  21. Eamer G, Taheri A, Chen SS, et al. Comprehensive geriatric assessment for older people admitted to a surgical service. Cochrane Database Syst Rev. 2018;1(1):CD012485. https://doi.org/10.1002/14651858.CD012485.pub2
  22. Klinicheskie rekomendacii. Starcheskaya asteniya. 2024-2025-2026 gg. (kod po Mezhdunarodnoj statisticheskoj klassifikacii boleznej i problem, svyazannyh so zdorov'em: R54). Utverzhdeny Minzdravom RF, 2024. (In Russ.).
  23. Park B, Bhat S, Xia W, Barazanchi AWH, Frampton C, Hill AG, MacCormick AD. Consensus-defined sarcopenia predicts adverse outcomes after elective abdominal surgery: meta-analysis. BJS Open. 2023;7(4):zrad065. https://doi.org/10.1093/bjsopen/zrad065
  24. Golounina OO, Fadeev VV, Belaya ZhE. Sovremennye rekomendacii po diagnostike sarkopenii. Klinicheskaya medicina. 2023;101(4-5):198-207. (In Russ.). https://doi.org/10.30629/0023-2149-2023-101-4-5-198-207
  25. Arends J, Bachmann P, Baracos V, et al. ESPEN guidelines on nutrition in cancer patients. Clinical Nutrition. 2017;36(1):11-48. 
  26. Agababyan TA, Kukarskaya VA, Silant'eva NA, Potapov AL, Skoropad VYu, Sheberova EV, Dorozhkin AD, Ivanov SA, Kaprin AD. Rol' KT-sarkometrii v prognozirovanii posleoperacionnyh oslozhnenij u bol'nyh rakom zheludka. Sovremennaya onkologiya. 2023;25(3):284-288. (In Russ.) https://doi.org/10.26442/18151434.2023.3.202260
  27. Yang T, Ji P, Deng X, Feng X, He M, Wang R, Li X. Ct-based diagnosis of sarcopenia as a prognostic factor for postoperative mortality after elective open-heart surgery in older patients: a cohort-based systematic review and meta-analysis. Front Public Health. 2024;8:12:1378462. https://doi.org/10.3389/fpubh.2024.1378462
  28. Fu H, Wang L, Zhang W, Lu J, Yang M. Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. 2023 Feb;14(1):57-70.  https://doi.org/10.1002/jcsm.13149
  29. Yan L, Nakamura T, Casadei-Gardini A, Bruixola G, Huang Y, Hu Z. Long-term and short-term prognostic value of the prognostic nutritional index in cancer: a narrative review. Ann Transl Med. 2021;9(21):1630. https://doi.org/10.21037/atm-21-4528
  30. Muscaritoli M, Arends J, Bachmann P, et al. ESPEN practical guideline: Clinical Nutrition in cancer. Clin Nutr. 2021;40(5):2898-2913. https://doi.org/10.1016/j.clnu.2021.02.005
  31. Liotiri D, Diamantis A, Paraskeva I, Brotis A, Symeonidis D, Arnaoutoglou E, Zacharoulis D. The Role of Enhanced Recovery after Surgery in Pancreaticoduodenectomy: A Systematic Review and Meta-Analysis. Eur Surg Res. 2024;65(1):95-115.  https://doi.org/10.1159/000539785
  32. Sauro KM, Smith C, Ibadin S, Thomas A, Ganshorn H, Bakunda L, Bajgain B, Bisch SP, Nelson G. Enhanced Recovery After Surgery Guidelines and Hospital Length of Stay, Readmission, Complications, and Mortality. A Meta-Analysis of Randomized Clinical Trials. JAMA Netw Open. 2024;7(6):e2417310. https://doi.org/10.1001/jamanetworkopen.2024.17310
  33. Pranavi AR, Sureshkumar S, Mahalakshmy T, Kundra P, Kate V. Adapted ERAS Pathway Versus Standard Care in Patients Undergoing Emergency Surgery for Perforation Peritonitis — a Randomized Controlled Trial. J Gastrointest Surg. 2022;26(1):39-49.  https://doi.org/10.1007/s11605-021-05184-x
  34. Correia M, Moreira I, Cabral S, Castro C, Cruz A, Magalhães B, Santos LL, Irving SC. Neoadjuvant Gastric Cancer Treatment and Associated Nutritional Critical Domains for the Optimization of Care Pathways: A Systematic Review. Nutrients. 2023;15(10):2241. https://doi.org/10.3390/nu15102241
  35. Singer P, De Waele E, Sanchez C, Ruiz Santana S, Montejo JC, Laterre PF, Soroksky A, Moscovici E, Kagan I. TICACOS international: A multi-center, randomized, prospective controlled study comparing tight calorie control versus Liberal calorie administration study. Clin Nutr. 2021 Feb;40(2):380-387.  https://doi.org/10.1016/j.clnu.2020.05.024
  36. Leyderman IN, Yaroshetskiy AI. Discussing protein requirements of intensive care UNIT (ICU) patients. Annals of Critical Care. 2018;3:59-66. (In Russ.). https://doi.org/10.21320/1818-474X-2018-3-59-66
  37. Compher C, Bingham AL, McCall M, Patel J, Rice TW, Braunschweig C, Liam McKeever L. Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr. 2022;46(1):12-41.  https://doi.org/10.1002/jpen.2267
  38. Heyland DK, Patel J, Compher C, et al. EFFORT Protein Trial team. The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial. Lancet. 2023 Feb 18;401(10376):568-576.  https://doi.org/10.1016/S0140-6736(22)02469-2
  39. Bels JLM, Thiessen S, van Gassel RJJ, et al. PRECISe study team. Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomized controlled trial in Belgium and the Netherlands. Lancet. 2024;404(10453):659-669.  https://doi.org/10.1016/S0140-6736(24)01304-7
  40. Heyland DK, Wibbenmeyer L, Pollack J, et al. RE-ENERGIZE Trial Team. A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries. N Engl J Med. 2022;387(11):1001-1010. https://doi.org/10.1056/NEJMoa2203364
  41. Tao W, Xu G, Zhou J, Luo Y, Li PS. Glutamine Supplementation on Burn Patients: A Systematic Review and Meta-analysis. J Burn Care Res. 2024;45(3):675-684.  https://doi.org/10.1093/jbcr/irae007
  42. Majeed MW, Finnegan E, Gallo Ruelas M, et al. Effectiveness of amino acid supplementation in preventing acute kidney injury following cardiac surgery: A systematic review and meta-analysis of randomized controlled trials. Acta Anaesthesiol Scand. 2025;69(6):e70037. https://doi.org/10.1111/aas.70037
  43. Mohsen G, Stroemer A, Mayr A, Kunsorg A, Stoppe C, Wittmann M, Velten M. Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis. Nutrients. 2023; 15(15):3414. https://doi.org/10.3390/nu15153414
  44. Giustina A, di Filippo L, Facciorusso A, et al. Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis. Rev Endocr Metab Disord. 2023;24(6):1011-1029. https://doi.org/10.1007/s11154-023-09831-3
  45. Singer P, Anbar R, Cohen J, et al The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med. 2011;37:601-609. 
  46. Weijs PJ, Stapel SN, de Groot SD, et al. Optimal protein and energy nutrition decreases mortality in mechanically ventilated, critically ill patients: a prospective observational cohort study. JPEN J Parenter Enteral Nutr. 2012;36(1):60-68. 
  47. Tesař M, Ostruzska P, Kožušníková V, Martínek L, Zádrapová M, Grasslová L, Ihnát P. Preoperative non-selective administration of nutritional supplements to patients undergoing elective colorectal resection — standard of perioperative care? Rozhl Chir. 2022;101(5):232-238.  https://doi.org/10.33699/PIS.2022.101.5.232-238
  48. Knight SR, Qureshi AU, Drake TM, et al. The impact of preoperative oral nutrition supplementation on outcomes in patients undergoing gastrointestinal surgery for cancer in low- and middle-income countries: a systematic review and meta-analysis. Sci Rep. 2022;12(1):12456. https://doi.org/10.1038/s41598-022-16460-4
  49. Cadili L, van Dijk PAD, Grudzinski AL, Cape J, Kuhnen AH. The effect of preoperative oral nutritional supplementation on surgical site infections among adult patients undergoing elective surgery: A systematic review and meta-analysis. Am J Surg. 2023;226(3):330-339.  https://doi.org/10.1016/j.amjsurg.2023.06.011
  50. Lai WY, Chiu YC, Lu KC, Huang IT, Tsai PS, Huang CJ. Beneficial effects of preoperative oral nutrition supplements on postoperative outcomes in geriatric hip fracture patients: A PRISMA-compliant systematic review and meta-analysis of randomized controlled studies. Medicine (Baltimore). 2021;100(47):e27755. https://doi.org/10.1097/MD.0000000000027755
  51. Potapov AL, Horonenko VE, Gameeva EV, Hajlova ZHV, Dorozhkin AD, Skoropad VYu. Dopolnitel'noe peroral'noe pitanie pri rake zheludka — obzor sovremennoj dokazatel'noj bazy. Issledovaniya i praktika v medicine. 2021;8(1):53-61. (In Russ.). https://doi.org/10.17709/2409-2231-2021-8-1-5
  52. Berkelmans GHK, Fransen LFC, Dolmans-Zwartjes ACP, Kouwenhoven EA, van Det MJ, Nilsson M, Nieuwenhuijzen GAP, Misha DP, Luyer MDP. Direct Oral Feeding Following Minimally Invasive Esophagectomy (NUTRIENT II trial): An International, Multicenter, Open-label Randomized Controlled Trial. Ann Surg. 2020;271(1):41-47.  https://doi.org/10.1097/SLA.0000000000003278
  53. Kovalerova NB, Ruchkin DV, Plotnikov GP. Vliyanie rannego peroral'nogo pitaniya na nutritivnyj status pacientov posle subtotal'noj ezofagektomii s odnomomentnoj plastikoj pishchevoda zheludochnoj trubkoj: randomizirovannoe odnocentrovoe issledovanie. Klinicheskoe pitanie i metabolizm. 2021;2(2):51-65. (In Russ.). https://doi.org/10.17816/clinutr81628
  54. Liu Y, Wu Z, Shao T, Zheng W, Huang J. Application of oral nutritional supplements to control body weight loss in postoperative patients suffering from solid tumors: a systematic review and meta-analysis. Front Nutr. 2025:12:1476463. https://doi.org/10.3389/fnut.2025.1476463
  55. Meng Q, Tan S, Jiang Y, Han J, Xi Q, Zhuang Q, Wu G. Post-discharge oral nutritional supplements with dietary advice in patients at nutritional risk after surgery for gastric cancer: A randomized clinical trial. Clin Nutr. 2021;40(1):40-46.  https://doi.org/10.1016/j.clnu.2020.04.043
  56. Rowley A, Adiamah A, Kushairi A, Lewis SJ, Lobo DN. The effect of post-discharge oral nutritional supplements on outcomes after gastrointestinal surgery: A systematic review and meta-analysis. Clin Nutr. 2023 Jul; 42(7):1189-1201. https://doi.org/10.1016/j.clnu.2023.04.028
  57. Potapov AL. Oral nutritional supplements in nutrition support for cancer surgery. Messenger of Anesthesiology and Resuscitation. 2020;17(2):64-69. (In Russ.). https://doi.org/10.21292/2078-5658-2020-17-2-64-69
  58. Potapov AL, Servitova MA, Samarin SA, Petrov VA, Leyderman IN. Vliyanie hemosensornyh narushenij na vkusovye predpochteniya u onkologicheskih pacientov, poluchayushchih dopolnitel'noe peroral'noe pitanie. Voprosy pitaniya. 2021;90(4):122-128. (In Russ.). https://doi.org/10.33029/0042-8833-2021-90-4-122-128
  59. Quist JR, Rud CL, Frumer K, Julsgaard M, Dahl Baunwall SM, Hvas CL. Osmolality in oral supplements drives ileostomy output: Defining the Goldilocks zone. Clin Nutr ESPEN. 2024;61:88-93.  https://doi.org/10.1016/j.clnesp.2024.03.003
  60. Klek S, Kret K, Choruz R, Pisarska-Adamczyk M, Salowka J, Tomasz Cegielny T, Welanyk J, Wilczek M, Pedziwiatr M. Immunomodulating versus high-protein oral preoperative supplement in surgical patients — A two-center, prospective, randomized clinical trial. Nutrition. 2022;101:111701. https://doi.org/10.1016/j.nut.2022.111701
  61. Rukovodstvo po klinicheskomu pitaniyu. Pod red. Lufta V.M. SPb: Art-Ekspress; 2023:556. (In Russ.).
  62. Leyderman IN, Mazurok VA, YArosheckij AI, Potapov AL, Rzheutskaya RE. Klyuchevye tekhnologii enteral'nogo pitaniya v mnogoprofil'noj klinike. Rukovodstvo dlya vrachej. SPb: Premium-Press; 2023:196. (In Russ.).
  63. Baik SM, Kim M, Lee JG. Comparison of Early Enteral Nutrition Versus Early Parenteral Nutrition in Critically Ill Patients: A Systematic Review and Meta-Analysis. Nutrients. 2024 Dec 24;17(1):10.  https://doi.org/10.3390/nu17010010
  64. Yirui L, Yin W, Juan L, Yanpei C. The clinical effect of early enteral nutrition in liver-transplanted patients: a systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. 2021 May;45(3):101594. https://doi.org/10.1016/j.clinre.2020.101594
  65. Burcharth J, Falkenberg A, Schack A, Ekeloef S, Gögenur I. The effects of early enteral nutrition on mortality after major emergency abdominal surgery: A systematic review and meta-analysis with Trial Sequential Analysis. Clin Nutr. 2021 Apr;40(4):1604-1612. https://doi.org/10.1016/j.clnu.2021.02.050
  66. Xu W, Ding X. The application effectiveness of an early enteral nutrition protocol constructed based on the enhanced recovery after surgery concept in ICU patients. Medicine (Baltimore). 2025;104(18):e42292. https://doi.org/10.1097/MD.0000000000042292
  67. Tarasova IA, Ckhovrebov AT, Bitarov TT, Boeva IA, Gardashov NM, Ivanova MV, SHestakov AL. Rol' enteral'nogo pitaniya v reabilitacii pacientov posle rekonstruktivnyh vmeshatel'stv na pishchevode i zheludke. Hirurgiya. Zhurnal im. N.I. Pirogova. 2023;2:35-42. (In Russ.). https://doi.org/10.17116/hirurgia202302135
  68. Zhang L, Liu Y, Gao X, Zhou D, Zhang Y, Tian F, Gao T, Wang Y, Chen Z, Lian B, Hu H, Jia Z, Xue Z, Guo D, Zhou J, Gu Y, Gong F, Wu X, Tang Y, Li M, Jin G, Qin H, Yu J, Zhou Y, Chi Q, Yang H, Wang K, Li G, Li N, van Zanten ARH, Li J, Wang X. Immediate vs. gradual advancement to goal of enteral nutrition after elective abdominal surgery: A multicenter non-inferiority randomized trial. Clin Nutr. 2021;40(12):5802-5811. https://doi.org/10.1016/j.clnu.2021.10.014
  69. Kagan I, Hellerman-Itzhaki M, Bendavid I, Statlender L, Fishman G, Wischmeyer PE, de Waele E, Singer P. Controlled enteral nutrition in critical care patients — A randomized clinical trial of a novel management system. Clin Nutr. 2023;42(9):1602-1609. https://doi.org/10.1016/j.clnu.2023.06.018
  70. Gianotti L, Braga M, Vignali A, et al. Effect of route of delivery and formulation of postoperative nutritional support in patients undergoing major operations for malignant neoplasms. Arch Surg. 1997;132(11):1222-1229.
  71. Zhu X, Wu Y, Qiu Y, et al. Comparative analysis of the efficacy and complications of nasojejunal and jejunostomy on patients undergoing pancreaticoduodenectomy. J Parenter Enteral Nutr. 2014;38(8):996-1002. https://doi.org/10.1177/0148607113500694
  72. Sica GS, Sujendran V, Wheeler J, et al. Needle catheter jejunostomy at esophagectomy for cancer. J Surg Oncol. 2005;91(4):276-279.  https://doi.org/10.1002/jso.20314
  73. Chin KF, Townsend S, Wong W, Miller GV. A prospective cohort study of feeding needle catheter jejunostomy in an upper gastrointestinal surgical unit. Clin Nutr. 2004;23(4):691-696.  https://doi.org/10.1016/j.clnu.2003.11.002
  74. Spravochnik po klinicheskomu pitaniyu. Luft VM, Lapickij AV, Borovik TE, Bushueva TV, Sergeeva AM. Sankt-Peterburgskij NII skoroj pomoshchi im. II. Dzhanelidze, Severo-Zapadnaya associaciya parenteral'nogo i enteral'nogo pitaniya. SPb: RA Russkij YUvelir; 2021:464. (In Russ.).
  75. Maruyama M, Goshi S, Kashima Y, Mizuhara A, Higashiguchi T. Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial. Nutr Clin Pract. 2020;35(3):464-470.  https://doi.org/10.1002/ncp.10392
  76. Tay VXP, Mohamed Noor NA, Tan LB. Effects of fibre-supplemented enteral feeds on bowel function of non-critically ill tube-fed adults: a meta-analysis of randomised controlled trials. Br J Nutr. 2023 Dec 28;130(12):2076-2087. https://doi.org/10.1017/S0007114523001289
  77. Huang HB, Zhu YB, Yu DX. Use of pectin-supplemented enteral nutrition in intensive care: A systematic review and meta-analysis. Clin Nutr ESPEN. 2025;68:62-70.  https://doi.org/10.1016/j.clnesp.2025.04.008
  78. Aver'yanova YuV, Batyrshin IM, Demko AE, Ivanova GE, Ivashkin VT, Kostyuchenko LN, Lapickij AV, Leyderman IN, Luft VM, Maev IV, Nikitin IG, Novruzbekov MS, Poluektova EA, Potapov AL, Sytov AV, Truhmanov AS. Klinicheskie rekomendacii severo-zapadnoj associacii parenteral'nogo i enteral'nogo pitaniya, mezhregional'noj associacii po neotlozhnoj hirurgii, rossijskoj gastroenterologicheskoj associacii, soyuza reabilitologov rossii i rossijskogo transplantacionnogo obshchestva po diagnostike i lecheniyu sindroma korotkoj kishki s kishechnoj nedostatochnost'yu u vzroslyh. Rossijskij zhurnal gastroenterologii, gepatologii i koloproktolgii. 2022;32(1):60-103. (In Russ.). https://doi.org/10.22416/1382-4376-2022-32-1-60-103
  79. Sytov AV, Zuzov SA, Kukosh MYu, Lejderman IN, Potapov AL, Hoteev AZh, Kucheryavyj YuA. Zamestitel'naya fermentnaya terapiya pri rake podzheludochnoj zhelezy. Zlokachestvennye opuholi. 2023;13(3s2-2):148-152. (In Russ.). https://doi.org/10.18027/2224-5057-2023-13-3s2-2-148-152
  80. Li J, Xiang Q, Zhu J, Zhang Y, Li S. Comparison of enteral immunonutrition and enteral nutrition in patients undergoing gastric cancer surgery: a systematic review and meta-analysis of randomized, controlled trials. J Int Med Res. 2024;52(1):1-19.  https://doi.org/10.1177/03000605231220870
  81. McKechnie T, Kazi T, Jessani G, Shi V, Sne N, Doumouras A, Hong D, Eskicioglu C. The use of preoperative enteral immunonutrition in patients undergoing elective colorectal cancer surgery: A systematic review and meta-analysis. Colorectal Dis. 2025;27(4):e70061. https://doi.org/10.1111/codi.70061
  82. Goyal A, Macias ChA, Corzo MP, Vargas VPS, Mendoza M, Castillo JEG, GarciaA, Morfin-Meza KD, Fuentes-Orozco C, González-Ojeda A, Suárez-Carreón LO, Ruiz-Úcar E, Vashist Y, Bonet AP, Abou-Mrad A, Oviedo RJ, Marano L. Perioperative Immunonutrition in Gastrointestinal Oncology: A Comprehensive Umbrella Review and Meta-Analysis on Behalf of TROGSS-The Robotic Global Surgical Society. Nutrients. 2025;17(14):2304. https://doi.org/10.3390/nu17142304
  83. Yu J, Yuan A, Liu Q, Wang W, Sun Y, Li Z, Meng C, Zhou Y, Cao S. Effect of preoperative immunonutrition on postoperative short-term clinical outcomes in patients with gastric cancer cachexia: a prospective randomized controlled trial. World J Surg Oncol. 2024;22(1):101.  https://doi.org/10.1186/s12957-024-03348-y
  84. Lee HY, Lee JK, Kim HJ, Ju DL, Lee SM, Lee J. Continuous versus Intermittent Enteral Tube Feeding for Critically Ill Patients: A Prospective, Randomized Controlled Trial. Nutrients. 2022 Feb 04;14(3):664.  https://doi.org/10.3390/nu14030664
  85. Ma Y, Cheng J, Liu L, Chen K, Fang Y, Wang G, Zhu J, Chen L. Intermittent versus continuous enteral nutrition on feeding intolerance in critically ill adults: A meta-analysis of randomized controlled trials. Int J Nurs Stud. 2021 Jan;113:103783. https://doi.org/10.1016/j.ijnurstu.2020.103783
  86. Misirlioglu M, Yildizdas D, Ekinci F, et al. An Assessment of Intermittent and Continuous Enteral Feeding in Critically Ill Children. Nutrients. 2025 Jan 15;17(2):301.  https://doi.org/10.3390/nu17020301
  87. Heidegger CP, Berger MM, Graf S, et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet. 2013;381(9864):385-393.  https://doi.org/10.1016/S0140-6736(12)61351-8
  88. Compher C, Bingham AL, McCall M, Patel J, Rice TW, Braunschweig C, Liam McKeever L. Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr. 2022;46(1):12-41.  https://doi.org/10.1002/jpen.2267
  89. Ma Y, Zhao X, Pan Y, Yang Y, Wang Y, Ge S. Early intravenous branched-chain amino acid-enriched nutrition supplementation in older patients undergoing gastric surgery: a randomized clinical trial. Nutr J. 2024;23(1):137.  https://doi.org/10.1186/s12937-024-01041-0
  90. Xu B, Chen H, Zhang Q, Chen P. Supplemental parenteral nutrition improves patient outcomes after esophageal cancer surgery: A single-center randomized controlled study. Medicine (Baltimore). 2022;101(47):e31893.
  91. Gao X, Liu Y, Zhang L, et al. Effect of Early vs Late Supplemental Parenteral Nutrition in Patients Undergoing Abdominal Surgery: A Randomized Clinical Trial. JAMA Surg. 2022;157(5):384-393.  https://doi.org/10.1001/jamasurg.2022.0269
  92. Khan A, Laing E, Beaumont A, Wong J, Warrier S, Heriot A. Peripheral parenteral nutrition in surgery — a systematic review and meta-analysis. Clin Nutr ESPEN. 2023;54:337-348.  https://doi.org/10.1016/j.clnesp.2023.02.004
  93. Leyderman IN, YArosheckij AI, Kokarev EA, Mazurok VA. Parenteral'noe pitanie: voprosy i otvety. Rukovodstvo dlya vrachej. SPb: Onli-Press; 2016:192. (In Russ.)
  94. Pichard C, Schwarz G, Frei A, et al. Economic investigation of the use of three-compartment total parenteral nutrition bag: prospective randomized unblinded controlled study. Clin Nutr. 2000;19(4):245-251. 
  95. Menne R, Adolph M, Brock E, et al. Cost analysis of parenteral nutrition regimens in the intensive care unit: three-compartment bag system vs multibottle system. J Parenter Enteral Nutr. 2008;32(6):606-612. 
  96. Turpin RS, Canada T, Rosenthal V, et al. IMPROVE Study Group. Bloodstream infections associated with parenteral nutrition preparation methods in the United States: a retrospective, large database analysis. J Parenter Enteral Nutr. 2012;36(2):169-176. 
  97. Pasechnik IN, Talyzin PA, Skobelev EI. Nutritivnaya podderzhka reanimacionnyh bol'nyh: rol' lipidnogo komponenta. Anesteziologiya i reanimatologiya. 2024;3:58-66. (In Russ.).
  98. Sadu Singh BK, Narayanan SS, Khor BH, Sahathevan S, Abdul Gafor AH, Fiaccadori E, Sundram K, Karupaiah T. Composition and Functionality of Lipid Emulsions in Parenteral Nutrition: Examining Evidence in Clinical Applications. Front Pharmacol. 2020 Apr 29;11:506. 
  99. Papandreou P, Gioxari A, Ntountaniotis D, Korda ON, Skouroliakou M, Siahanidou T. Administration of an Intravenous Fat Emulsion Enriched with Medium-Chain Triglyceride/ω-3 Fatty Acids is Beneficial Towards Anti-Inflammatory Related Fatty Acid Profile in Preterm Neonates: A Randomized, Double-Blind Clinical Trial. Nutrients. 2020 Nov 16;12(11):3526. PMID: 33207743. https://doi.org/10.3390/nu12113526
  100. Adolph M. Lipid emulsions in parenteral nutrition. Ann Nutr Metab. 1999; 43(1):1-13.  https://doi.org/10.1159/000012761
  101. Calder PC. Hot topics in parenteral nutrition. Rationale for using new lipid emulsions in parenteral nutrition and a review of the trials performed in adults. Proc Nutr Soc. 2009 Aug;68(3):252-260.  https://doi.org/10.1017/S0029665109001268
  102. Miles EA, Calder PC. Fatty acids, lipid emulsions and the immune and inflammatory systems. World Rev Nutr Diet. 2015;112:17-30.  https://doi.org/10.1159/000365426
  103. Grau T, Ruiz de Adana JC, Zubillaga S, Fuerte S, Girón C. Estudio aleatorio de dos emulsiones grasas diferentes en la nutrición parenteral total del enfermo quirúrgico desnutrido: efecto sobre la morbilidad infecciosa y la mortalidad. Randomized study of two different fat emulsions in total parenteral nutrition of malnourished surgical patients;effect of infectious morbidity and mortality]. Nutr Hosp. 2003 May-Jun;18(3):159-166. (In Spanish).
  104. Faucher M, Bregeon F, Gainnier M, Thirion X, et al. Cardiopulmonary Effects of Lipid Emulsions in Patients With ARDS. Chest. 2003;124:285-291. 
  105. Notz Q, Lee ZY, Menger J, Elke G, Hill A, Kranke P, Roeder D, Lotz C, Meybohm P, Heyland DK, Stoppe C. Omega-6 sparing effects of parenteral lipid emulsions-an updated systematic review and meta-analysis on clinical outcomes in critically ill patients. Crit Care. 2022 Jan 19;26(1):23.  https://doi.org/10.1186/s13054-022-03896-3
  106. Pradelli L, Mayer K, Klek S, Rosenthal MD, Povero M, Heller AR, Muscaritoli M. Omega-3 fatty acids in parenteral nutrition — A systematic review with network meta-analysis on clinical outcomes. Clin Nutr. 2023 Apr;42(4):590-599.  https://doi.org/10.1016/j.clnu.2023.02.008
  107. Grau-Carmona T, Bonet-Saris A, Abelardo GL, et al. Influence of n-3 polyunsaturated fatty acids enriched lipid emulsions on nosocomial infections and clinical outcomes in critically ill patients: ICU lipids study. Crit Care Med. 2015;43(1):31-39. 
  108. Pradelli L, Mayer K, Klek S, et al. Omega-3 fatty-acid enriched parenteral nutrition in hospitalized patients: systematic review with meta-analysis and trial sequential analysis. J Parenter Enter Nutr. 2020;44(1):44-57. 
  109. Pradelli L, Heller AR, Klek S, Mayer K, Rosenthal MD, Muscaritoli M. Parenteral Nutrition Containing Fish Oil for Hospitalized Non-Intensive Care Unit (ICU) Patients: A Systematic Review, Meta-Analysis, and Cost-Effectiveness Analysis. Nutrients. 2025 Apr 07;17(7):1284. https://doi.org/10.3390/nu17071284
  110. Calder PC, Jensen GL, Koletzko BV, Singer P, Wanten GJ. Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions. Intensive Care Med. 2010 May;36(5):735-749.  https://doi.org/10.1007/s00134-009-1744-5
  111. Weimann A, Braga M, Carli F, Higashiguchi T, Hubner M, Klek S, et al. ESPEN guideline: clinical nutrition in surgery. Clin Nutr. 2017;36:623-650. 
  112. Jiang Z, Jiang H. The clinical efficacy of glutamine dipeptides on postoperative patients: an updated systematic review of randomized controlled trials from Europe and Asia (1997-2005). Zhonghua Yi Xue Za Zhi. 2006;86(23):1610-1614.
  113. Yue C, Tian W, Wang W, Huang Q, Zhao R, Zhao Y, Li Q, Li J. The impact of perioperative glutamine-supplemented parenteral nutrition on outcomes of patients undergoing abdominal surgery: a meta-analysis of randomized clinical trials. Am Surg. 2013 May;79(5):506-13. 
  114. Perez-Barcena J, Marce P, Zabalegui-Pérez A, et al. A randomized trial of intravenous glutamine supplementation in trauma ICU patients. Intensive Care Med. 2014;40(4):539-547. 
  115. Andrews PJD, Avenell A, Noble DW, et al. Randomized trial of glutamine, selenium, or both, to supplemental parenteral nutrition for critically ill patients. BMJ. 2011;342:1542.
  116. Ziegler TR, May AK, Hebbar G, et al. Efficacy and safety of glutamine-supplemented parenteral nutrition in surgical ICU patients: an American multicenter randomized controlled trial. Ann Surg. 2016;263(4):646-655. 
  117. Yao GX, Xue XB, Jiang ZM, Yang NF, Wilmore DW. Effects of perioperative parenteral glutamine-dipeptide supplementation on plasma endotoxin level, plasma endotoxin inactivation capacity and clinical outcome. Clin Nutr. 2005;24:510-515. 
  118. Bollhalder L, Pfeil AM, Tomonaga Y, Schwenkglenks M. A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation. Clin Nutr. 2013;32:213e23.
  119. Wang Y, Jiang ZM, Nolan MT, Jiang H, Han HR, Yu K, et al. The impact of glutamine dipeptideesupplemented parenteral nutrition on outcomes of surgical patients: a meta-analysis of randomized clinical trials. J Parenter Enter Nutr. 2010;34:521-529. 
  120. Cui Y, Hu L, Liu Y-J, Wu Y-M, Jing L. Intravenous alanyl-L-glutamine balances glucose-insulin homeostasis and facilitates recovery in patients undergoing colonic resection: a randomised controlled trial. Eur J Anaesthesiol. 2014;31:212-218. 
  121. Heyland D, Muscedere J, Wischmeyer PE, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368(16):1489-1497.
  122. Kang K, Shu XL, Zhang YS, Liu XL, Zhao J. Effect of glutamine enriched nutrition support on surgical patients with gastrointestinal tumor: a metaanalysis of randomized controlled trials. Chin Med J (Engl Ed). 2015;128:245-251. 
  123. Sandini M, Nespoli L, Oldani M, Bernasconi DP, Gianotti L. Effect of glutamine dipeptide supplementation on primary outcomes for elective major surgery: systematic review and meta-analysis. Nutrients. 2015;7:481-499. 
  124. Wu JM, Ho TW, Lai IR, Chen CN, Lin MT. Parenteral glutamine supplementation improves serum albumin values in surgical cancer patients. Clin Nutr. 2021 Feb;40(2):645-650.  https://doi.org/10.1016/j.clnu.2020.06.015
  125. Tang G, Pi F, Qiu YH, Wei ZQ. Postoperative parenteral glutamine supplementation improves the short-term outcomes in patients undergoing colorectal cancer surgery: A propensity score matching study. Front Nutr. 2023 Mar 16;10:1040893. https://doi.org/10.3389/fnut.2023.1040893
  126. Blaauw R, Osland E, Sriram K, et al. Parenteral Provision of Micronutrients to Adult Patients: An Expert Consensus Paper. J Parent Enter Nutr. 2019; 43(Suppl 1):S5-S23.  https://doi.org/10.1002/jpen.1525
  127. Hoeger J, Simon T-P, Beeker T, Marx G, Haase H, Schuerholz T. Persistent low serum zinc is associated with recurrent sepsis in critically ill patients — a pilot study. PLoS One. 2017;12:0176069.
  128. Ben-Hamouda N, Charriere M, Voirol P, Berger MM. Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement. Nutrition. 2017;34:71-75. 
  129. Fukuda Y, Yamamoto K, Hirao M, et al. Prevalence of Malnutrition Among Gastric Cancer Patients Undergoing Gastrectomy and Optimal Preoperative Nutritional Support for Preventing Surgical Site Infections. Ann Surg Oncol. 2015 Dec;22(Suppl 3):S778-S785. https://doi.org/10.1245/s10434-015-4820-9
  130. Xu JY, Tian XD, Song JH. Preoperative Nutrition Support May Reduce the Prevalence of Postoperative Pancreatic Fistula after Open Pancreaticoduodenectomy in Patients with High Nutritional Risk Determined by NRS2002. Biomed Res Int. 2021;2021:6691966. https://doi.org/10.1155/2021/6691966
  131. Yarosheckij AI. Refiding-sindrom. Vozobnovlenie pitaniya pri nervnoj anoreksii. Pallium: Palliativnaya i hospisnaya pomoshch'. 2023;4(21):21-26. eLibrary ID: 58905633. (In Russ.).
  132. Cioffi I, Ponzo V, Pellegrini M, Evangelista A, Bioletto F, Ciccone G, Pasanisi F, Ghigo E, Bo S. The incidence of the refeeding syndrome. A systematic review and meta-analyses of literature. Clin Nutr. 2021 Jun; 40(6):3688-3701. https://doi.org/10.1016/j.clnu.2021.04.023
  133. Fleurent-Grégoire C, Burgess N, McIsaac DI, et al. Towards a common definition of surgical prehabilitation: a scoping review of randomised trials. Br J Anaesth. 2024;133(2):305-315.  https://doi.org/10.1016/j.bja.2024.02.035
  134. Venter S, Liu X, Koh C, Solomon M, Cole R, Hirst N, Steffens D. The Power of Prehabilitation, the Reporting of Power Calculations in Randomized Clinical Trials Evaluating Prehabilitation in Cancer Surgery: A Systematic Review and Meta-research Study. Arch Phys Med Rehabil. 2025 Jul; 106(7):1081-1091. https://doi.org/10.1016/j.apmr.2025.01.465
  135. Soh NH, Yau CRZ, Low XZ, Kadir HA, Fong WJ, Ramalingam MB, Tan PL, Ng KYY, Hsing YT, Cai M, Seo CJ, Ong JC, Chia CS, Wong JSM. Prehabilitation Outcomes in Surgical Oncology Patients Undergoing Major Abdominal Surgery: A Meta-analysis of Randomized Control Trials. Ann Surg Oncol. 2025 Feb;32(2):1236-1247. https://doi.org/10.1245/s10434-024-16527-8
  136. Toneev EA, Komarov AS, Midlenko OV, Golovatyukov AV, Isaev DN. Mul'tidisciplinarnaya prereabilitaciya pri planirovanii lobektomii: randomizirovannoe klinicheskoe issledovanie. Sovremennye problemy nauki i obrazovaniya. 2024;1:15. (In Russ.). https://doi.org/10.17513/spno.33265
  137. Skořepa P, Ford KL, Alsuwaylihi A, et al. The impact of prehabilitation on outcomes in frail and high-risk patients undergoing major abdominal surgery: A systematic review and meta-analysis. Clin Nutr. 2024;43(3):629-648.  https://doi.org/10.1016/j.clnu.2024.01.020
  138. McIsaac DI, Kidd G, Gillis C, et al. Relative efficacy of prehabilitation interventions and their components: systematic review with network and component network meta-analyses of randomised controlled trials. BMJ. 2025:388:e081164. https://doi.org/10.1136/bmj-2024-081164

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