The role of some inflammatory markers in diagnosis of acute peritonitis in patients with HIV infection

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OBJECTIVE

To evaluate the effectiveness of leukocyte, NLR, procalcitonin and C-reactive protein as the markers of acute peritonitis in patients with HIV-infection.

MATERIAL AND METHODS

The study included 83 HIV-infected patients with various diseases complicated by acute peritonitis. Leukocytes, procalcitonin and C-reactive protein, as well as immune status and viral load were determined in peripheral blood before surgery. NLR was also estimated. Patients were divided into four groups depending on immune status. We analyzed leukocyte count, NLR, procalcitonin and C-reactive protein depending on immune deficiency and viral load.

RESULTS

Reduced immune status is followed by higher viral load. At the same time, there is a direct dependence of leukocyte count on immune status, and leukocyte count itself does not exceed the threshold values. Procalcitonin and C-reactive protein do not correlate with severity of immunodeficiency and exceed the reference values by tens of times. There is no correlation between NLR and immune status. However, threshold values of this indicator are not clear.

CONCLUSION

Leukocyte count is of minor importance in diagnosis of acute peritonitis in patients with HIV-infection. The role of NLR is not entirely clear in these patients and requires further study. Procalcitonin and C-reactive protein can be used as additional markers of acute peritonitis in HIV-positive patients.

Keywords:

leukocytes

NLR

procalcitonin

C-reactive protein

peritonitis

HIV-infection

Authors:

Faller A.P.

Infectious Diseases Hospital No.2;
Russian Biotechnological University

ORCID: 0009-0008-2304-9743

Kurnosov A.V.

Infectious Diseases Hospital No.2

ORCID: 0009-0000-5859-0064

Sundukov A.V.

Evdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0002-3798-7780

Received:

20.02.2024

Accepted:

29.02.2024

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