Prevention of thrombotic complications in critically ill children

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BACKGROUND

Thrombotic complications are common in critically ill children requiring prolonged intensive care. Identification of risk factors of thrombosis with simultaneous assessment of the likelihood of hemorrhagic complications underlies decision making on prevention of hypercoagulation. However, there are currently no clear recommendations and schemes of anticoagulation for certain diseases.

OBJECTIVE

To analyze risk factors, current methods of prevention and treatment of thrombotic complications in critically ill children.

MATERIAL AND METHODS

We analyzed 65 articles in the PubMed and Russian Science Citation Index databases between 2017 and 2022. The following keywords were used: «thromboprophylaxis», «thromboembolism», «intensive care unit», «critical care», «pediatric», «thrombosis in children», «thromboprophylaxis in children».

RESULTS

The main risk factors of thrombotic complications in children are age up to one year and severe diseases requiring long-term immobilization and accompanied by coagulopathy.

CONCLUSION

The main method of preventing thrombotic complications in children is the earliest possible motor activity of ICU patients. The most effective drugs are high and low molecular weight heparins, although there is currently no clear opinion.

Keywords:

thrombosis

thrombotic complications

thromboprophylaxis

intensive care

children

Authors:

Tsygankov A.E.

Morozovskaya Children’s City Clinical Hospital;
Research Institute for Healthcare Organization and Medical Management

ORCID: 0000-0003-3600-2801

Aleksandrovich Yu.S.

Children’s Scientific Clinical Center for Infectious Diseases

ORCID: 0000-0002-2131-4813

Lekmanov A.U.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-0798-1625

Afukov I.I.

Pirogov Russian National Research Medical University;
Moscow Healthcare Department

ORCID: 0000-0001-9850-6779

Gorokhov D.V.

Morozovskaya Children’s City Clinical Hospital

ORCID: 0000-0003-0517-3376

Kostomarova E.A.

Filatov Children’s City Clinical Hospital

ORCID: 0000-0003-0635-0397

Received:

28.07.2022

Accepted:

14.12.2022

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