Effects of repeated anesthesia on cognitive functions in children

Zolotareva L.S.; Adler A.V.; Paponov O.N.; Stepanenko S.M.; Zapunidi A.A.

doi:https://doi.org/10.17116/anaesthesiology202201154

Zolotareva L.S.

Pirogov Russian National Research Medical University

Adler A.V.

Filatov Children`s Hospital

Paponov O.N.

Children’s City Clinical Hospital named after N.F. Filatov

Stepanenko S.M.

Pirogov Russian National Research Medical University

Zapunidi A.A.

Lomonosov Moscow State University

Effects of repeated anesthesia on cognitive functions in children

Authors:

Zolotareva L.S., Adler A.V., Paponov O.N., Stepanenko S.M., Zapunidi A.A.

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Journal: Russian Journal of Anesthesiology and Reanimatology. 2022;(1): 54‑59

DOI: 10.17116/anaesthesiology202201154

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To cite this article:

Zolotareva LS, Adler AV, Paponov ON, Stepanenko SM, Zapunidi AA. Effects of repeated anesthesia on cognitive functions in children. Russian Journal of Anesthesiology and Reanimatology. 2022;(1):54‑59. (In Russ.)
https://doi.org/10.17116/anaesthesiology202201154

Использование инфографики авторами научных работ

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OBJECTIVE

To evaluate the effect of repeated anesthesia on cognitive functions in children.

MATERIAL AND METHODS

An observational cross-sectional study included children who had ≥5 previous surgeries (n=28, the main group) and children without previous interventions (n=36, the control group). The median age was 7.0 (6.0; 7.0) years. At the second stage, correlation analysis included 31 children who underwent repeated anesthetic exposure. Median age was 6.5 (6.0; 8.0) years. Neuropsychological tests included: Raven’s progressive matrices, Mini-Mental State Examination (MMSE), mechanical and associative memory test and proofreading tests.

RESULTS

The result of Raven’s matrices was higher in the control group compared to the main group (19.9±5.5 vs 22.5±4.7 scores, respectively; p=0.05). MMSE score was significantly higher in the main group compared to the control group (29.0 (24.3; 32.8) and 32.0 (29.6; 33.0) scores, respectively; p=0.04). We found significant negative correlation between the number of previous surgeries under general anesthesia and attention productivity (R= –0.375 (–0.648; –0.017), p=0.041), attention span (R= –0.422 (–0.665; –0.098), p=0.020) and pooled indicator of attention accuracy and span (R= –0.412 (–0.655; –0.091), p=0.024).

CONCLUSION

Multiple surgeries under general anesthesia are associated with poorer neuropsychological outcomes (Raven’s matrices, MMSE). Attention productivity and span correlate with the number of previous surgical interventions.

Keywords:

general anesthesia

postoperative cognitive dysfunction

children

preschool children

neuropsychological tests

Authors:

Zolotareva L.S.

Pirogov Russian National Research Medical University

Adler A.V.

Filatov Children`s Hospital

Paponov O.N.

Children’s City Clinical Hospital named after N.F. Filatov

Stepanenko S.M.

Pirogov Russian National Research Medical University

Zapunidi A.A.

Lomonosov Moscow State University

Received:

08.07.2021

Accepted:

06.09.2021

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References:

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