INTRODUCTION

Today, complications of the course of acute poisoning with modern psychoactive substances with narcotic effect are of particular interest to researchers. This group includes delirious states, accompanied by a qualitative change in consciousness and severe metabolic disorders that require intensive therapy in an intensive care unit. The available literary sources do not describe neurophysiological changes in patients with delirium in acute poisoning with a precursor of gamma-hydroxybutyric acid 1.4-butanediol, which determines the relevance of the study.

OBJECTIVE

To analyze the neurophysiological features of delirium in acute severe poisoning with 1.4-butanediol, taking into account the use of a substrate antihypoxant based on succinic acid in the treatment.

RESULTS

During the work, changes in the spectral composition of the electroencephalogram (EEG) were established in the form of a predominance of slow-wave activity, the absence of an α-rhythm in patients on the first day of delirium. The total index of dominant waves (θ-, δ-), low-amplitude polymorphic slow-wave activity) correlated with the overall severity of delirium symptoms on the DRS-R-98 scale (R_α=–0.54, R_θ,δ,NPMA=0.53, R_β=0.45). Against the background of Cytoflavin therapy, a more pronounced positive effect was achieved in the form of a reduction in psychotic symptoms, improvement of visual-spatial orientation, emotional state, speech and mental functions by the 7th day of treatment, in contrast to the comparison group. In the group of patients with delirium, when a substrate antihypoxant was used in treatment, by the 7th day, a gradual recovery of α-activity, a decrease in the power of θ-activity of EEG against the background of a decrease in the overall severity of delirious symptoms on the DRS-R-98 scale were observed.

CONCLUSION

Thus, the severity of the condition of patients with delirium in acute poisoning with 1.4-butanediol caused pronounced changes in the amplitude-frequency characteristics of EEG. Recovery of electrophysiological parameters was observed in direct connection with a change in the severity of the main symptoms of post-intoxication psychosis. It was established that a substrate antihypoxant based on succinic acid has a positive effect on the spectral power of EEG and the clinical course of delirium.