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Krichevsky L.A.

Yudin Clinical Hospital

Rybakov V.Yu.

Yudin Clinical Hospital;
Pirogov Russian National Research Medical University

Dvoryadkin A.A.

Yudin Clinical Hospital;
Pirogov Russian National Research Medical University

Protsenko D.N.

«Kommunarka» Moscow Multidisciplinary Clinical Center of the Moscow City Healthcare Department;
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Systemic inflammatory response in cardiac surgery

Authors:

Krichevsky L.A., Rybakov V.Yu., Dvoryadkin A.A., Protsenko D.N.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2021;(3): 94‑102

DOI: 10.17116/anaesthesiology202103194

Views: 6252

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To cite this article:

Krichevsky LA, Rybakov VYu, Dvoryadkin AA, Protsenko DN. Systemic inflammatory response in cardiac surgery. Russian Journal of Anesthesiology and Reanimatology. 2021;(3):94‑102. (In Russ.)
https://doi.org/10.17116/anaesthesiology202103194

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On-pump cardiac surgery is associated with high risk of systemic inflammatory response. According to recent data, cardiopulmonary bypass, myocardial and pulmonary ischemia-reperfusion, contact activation of leukocytes, anti- and pro-coagulation, lung ventilation, surgical trauma and others are powerful triggers of inflammatory response after cardiac surgery. Combination of these factors results an uncontrolled synthesis of various pro- and anti-inflammatory mediators, which directly or indirectly cause endothelial dysfunction, vascular permeability and systemic inflammatory response with multiple organ dysfunction. This review is devoted to analysis and systematization of the causes of inflammatory response after on-pump cardiac surgery. The authors discuss the mechanisms of systemic inflammatory response in cardiac surgery and the most common complications associated with inflammatory response. Moreover, modern methods of systemic inflammation correction (pharmacological, surgical and technical ones) including those not yet implemented in Russia are considered. The following databases were used: Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI.

Keywords:

review
cardiac surgery
systemic inflammatory response syndrome
cardiopulmonary bypass
multiple organ failure
post-perfusion vasoplegia
nitric oxide
terlipressin
hydroxocobalamin
methylene blue
norepinephrine
respiratory failure
glucocorticoids
ascorbic acid

Authors:

Krichevsky L.A.

Yudin Clinical Hospital

Rybakov V.Yu.

Yudin Clinical Hospital;
Pirogov Russian National Research Medical University

Dvoryadkin A.A.

Yudin Clinical Hospital;
Pirogov Russian National Research Medical University

Protsenko D.N.

«Kommunarka» Moscow Multidisciplinary Clinical Center of the Moscow City Healthcare Department;
N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Received:

25.11.2020

Accepted:

18.12.2020

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