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Kulikov A.V.

Institute of Theoretical and Experimental Biophysics of the RAS

Shifman E.M.

Moscow Regional Research and Clinical Institute

Roitman E.V.

Pirogov Russian National Research Medical University;
Research Center of Neurology

Ovezov A.M.

Moscow Regional Research and Clinical Institute

Zabolotskikh I.B.

Kuban State Medical University

Marshalov D.V.

Razumovsky Saratov State Medical University

Raspopin Yu.S.

Voino-Yasenetsky Krasnoyarsk State Medical University

Prevention and treatment of hemorrhagic complications associated with antitrombotic drugs during analgesia in labour and anesthesia in caesarean section. Guidelines

Authors:

Kulikov A.V., Shifman E.M., Roitman E.V., Ovezov A.M., Zabolotskikh I.B., Marshalov D.V., Raspopin Yu.S.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2021;(2): 6‑18

DOI: 10.17116/anaesthesiology20210216

Read: 9477 times

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Table of contents

PREVENTION AND TREATMENT OF HEMORRHAGIC COMPLICATIONS ASSOCIATED WITH ANTITROMBOTIC DRUGS DURING ANALGESIA IN LABOUR AND ANESTHESIA IN CAESAREAN SECTION. GUIDELINES
PREVENTION AND TREATMENT OF HEMORRHAGIC COMPLICATIONS ASSOCIATED WITH ANTITROMBOTIC DRUGS DURING ANALGESIA IN LABOUR AND ANESTHESIA IN CAESAREAN SECTION. GUIDELINES

To cite this article:

Kulikov AV, Shifman EM, Roitman EV, Ovezov AM, Zabolotskikh IB, Marshalov DV, Raspopin YuS. Prevention and treatment of hemorrhagic complications associated with antitrombotic drugs during analgesia in labour and anesthesia in caesarean section. Guidelines. Russian Journal of Anesthesiology and Reanimatology. 2021;(2):6‑18. (In Russ.)
https://doi.org/10.17116/anaesthesiology20210216

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Abstract:

The article discusses the safety of the use of unfractionated and low molecular weight heparin, vitamin K1 antagonists, acetylsalicylic acid and other antithrombotic drugs during pregnancy, in the perioperative and postpartum periods. Some methods are recommended for the prevention of hemorrhagic complications in conditions of antithrombotic medications and their inactivation in an emergency.

Keywords:

pregnancy
anticoagulants
heparin
delivery
neuraxial anesthesia
lactation

Authors:

Kulikov A.V.

Institute of Theoretical and Experimental Biophysics of the RAS

Shifman E.M.

Moscow Regional Research and Clinical Institute

Roitman E.V.

Pirogov Russian National Research Medical University;
Research Center of Neurology

Ovezov A.M.

Moscow Regional Research and Clinical Institute

Zabolotskikh I.B.

Kuban State Medical University

Marshalov D.V.

Razumovsky Saratov State Medical University

Raspopin Yu.S.

Voino-Yasenetsky Krasnoyarsk State Medical University

Received:

10.02.2020

Accepted:

28.02.2020

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References:

  1. Sénat MV, Sentilhes L, Battut A, Benhamou D, et al. Postpartum practice: guidelines for clinical practice from the French College of Gynaecologists and Obstetricians (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2016;202:1-8.  https://doi.org/10.1016/j.ejogrb.2016.04.032.
  2. Ducloy-Bouthors AS, Baldini A, Abdul-Kadir R, Nizard J; ESA VTE Guidelines Task Force. European guidelines on perioperative venous thromboembolism prophylaxis: Surgery during pregnancy and the immediate postpartum period. Eur J Anaesthesiol. 2018;35(2):130-133.  https://doi.org/10.1097/EJA.0000000000000704.
  3. Royal College of Obstetricians and Gynaecologists. Reducing the Risk of Venous Thromboembolism during Pregnancy and the Puerperium. Green-top Guideline No. 37a. April 2015:40. 
  4. Rath W, Tsikouras P, von Tempelhoff GF. Medikamentöse Thromboembolie-Prophylaxe in Schwangerschaft und Wochenbett: neue Leitlinienempfehlungen & kritischer Leitlinienvergleich [Pharmacological Thromboprophylaxis during Pregnancy and the Puerperium: Recommendations from Current Guidelines and their Critical Comparison]. Z Geburtshilfe Neonatol. 2016;220(3):95-105. (In German). https://doi.org/10.1055/s-0042-106654
  5. Hutchinson-Jones NW, Didcott SK, Jones MD, Crowe JN. Implementation of a standardised annual anticoagulation specialist review in primary care. Prim Health Care Res Dev. 2020;21:e17.  https://doi.org/10.1017/S1463423620000171
  6. Tardy B, Chalayer E, Kamphuisen PW, Ni Ainle F, et al. SSC Subcommittee on Control of Anticoagulation of the ISTH. Definition of bleeding events in studies evaluating prophylactic antithrombotic therapy in pregnant women: A systematic review and a proposal from the ISTH SSC. J Thromb Haemost. 2019;17(11):1979-1988. https://doi.org/10.1111/jth.14576
  7. Leffert L, Butwick A, Carvalho B, Arendt K, Bates SM, Friedman A, Horlocker T, Houle T, Landau R, Dubois H, Fernando R, Houle T, Kopp S, Montgomery D, Pellegrini J, Smiley R, Toledo P; members of the SOAP VTE Taskforce. The Society for Obstetric Anesthesia and Perinatology Consensus Statement on the Anesthetic Management of Pregnant and Postpartum Women Receiving Thromboprophylaxis or Higher Dose Anticoagulants. Anesth Analg. 2018;126(3):928-944.  https://doi.org/10.1213/ANE.0000000000002530
  8. Leffert LR, Dubois HM, Butwick AJ, Carvalho B, Houle TT, Landau R. Neuraxial Anesthesia in Obstetric Patients Receiving Thromboprophylaxis With Unfractionated or Low-Molecular-Weight Heparin: A Systematic Review of Spinal Epidural Hematoma. Anesth Analg. 2017;125(1):223-231.  https://doi.org/10.1213/ANE.0000000000002173
  9. Horlocker TT, Vandermeuelen E, Kopp SL, Gogarten W, Leffert LR, Benzon HT. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Fourth Edition). Reg Anesth Pain Med. 2018;43(3):263-309.  https://doi.org/10.1097/AAP.0000000000000763
  10. Fonseca NM, Pontes JPJ, Perez MV, Alves RR, Fonseca GG. SBA 2020: Atualização na diretriz da anestesia regional em uso de anticoagulantes [SBA 2020: Regional anesthesia guideline for using anticoagulants update]. Rev Bras Anestesiol. 2020;70(4):364-387. (In Portuguese). https://doi.org/10.1016/j.bjan.2020.02.006
  11. Wolfe RC, Evans T. Antithrombotic Therapy and Regional Anesthesia. J Perianesth Nurs. 2019;34(2):439-446.  https://doi.org/10.1016/j.jopan.2019.01.001
  12. Yentis SM, Lucas DN, Brigante L, Collis R, Cowley P, Denning S, Fawcett WJ, Gibson A. Safety guideline: neurological monitoring associated with obstetric neuraxial block 2020: A joint guideline by the Association of Anaesthetists and the Obstetric Anaesthetists’ Association. Anaesthesia. 2020;75(7):913-919.  https://doi.org/10.1111/anae.14993.
  13. Working Party: Association of Anaesthetists of Great Britain & Ireland; Obstetric Anaesthetists’ Association; Regional Anaesthesia UK. Regional anesthesia and patients with abnormalities of coagulation: the Association of Anaesthetists of Great Britain & Ireland The Obstetric Anaesthetists’ Association Regional Anaesthesia UK. Anaesthesia. 2013;68(9):966-972.  https://doi.org/10.1111/anae.12359
  14. Wilson RD, Caughey AB, Wood SL, Macones GA, Wrench IJ, Huang J, Norman M, Pettersson K, Fawcett WJ, Shalabi MM, Metcalfe A, Gramlich L, Nelson G. Guidelines for Antenatal and Preoperative care in Cesarean Delivery: Enhanced Recovery After Surgery Society Recommendations (Part 1). Am J Obstet Gynecol. 2018;219(6):523.e1-523.e15.  https://doi.org/10.1016/j.ajog.2018.09.015
  15. Shaban A, Moritani T, Al Kasab S, Sheharyar A, Limaye KS, Adams HP Jr. Spinal Cord Hemorrhage. J Stroke Cerebrovasc Dis. 2018;27(6):1435-1446. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.014
  16. Lagerkranser M. Neuraxial blocks and spinal haematoma: Review of 166 case reports published 1994-2015. Part 1: Demographics and risk-factors. Scand J Pain. 2017;15:118-129.  https://doi.org/10.1016/j.sjpain.2016.11.008
  17. Lagerkranser M, Lindquist C. Neuraxial blocks and spinal haematoma: Review of 166 cases published 1994-2015. Part 2: diagnosis, treatment, and outcome. Scand J Pain. 2017;15:130-136.  https://doi.org/10.1016/j.sjpain.2016.11.009
  18. Lee LO, Bateman BT, Kheterpal S, Klumpner TT, Housey M, Aziz MF, Hand KW, MacEachern M, Goodier CG, Bernstein J, Bauer ME; Multicenter Perioperative Outcomes Group Investigators. Risk of Epidural Hematoma after Neuraxial Techniques in Thrombocytopenic Parturients: A Report from the Multicenter Perioperative Outcomes Group. Anesthesiology. 2017;126(6):1053-1063. https://doi.org/10.1097/ALN.0000000000001630.
  19. Bernstein J, Hua B, Kahana M, Shaparin N, Yu S, Davila-Velazquez J. Neuraxial Anesthesia in Parturients with Low Platelet Counts. Anesth Analg. 2016;123(1):165-167.  https://doi.org/10.1213/ANE.0000000000001312
  20. Lu E, Shatzel JJ, Salati J, DeLoughery TG. The Safety of Low-Molecular-Weight Heparin During and After Pregnancy. Obstet Gynecol Surv. 2017;72(12):721-729.  https://doi.org/10.1097/OGX.0000000000000505
  21. Rosero EB, Joshi GP. Nationwide incidence of serious complications of epidural analgesia in the United States. Acta Anaesthesiol Scand. 2016; 60(6):810-820.  https://doi.org/10.1111/aas.12702
  22. De Cassai A, Correale C, Sandei L. Neuraxial and Perineural Bleeding after Neuraxial Techniques: An Overview of the Last Year. Eurasian J Med. 2020;52(2):211-216.  https://doi.org/10.5152/eurasianjmed.2019.19212
  23. Maddali P, Moisi M, Page J, Chamiraju P, Fisahn C, Oskouian R, Tubbs RS. Anatomical complications of epidural anesthesia: A comprehensive review. Clin Anat. 2017;30(3):342-346.  https://doi.org/10.1002/ca.22831
  24. Neal JM, Barrington MJ, Brull R, Hadzic A, Hebl JR, Horlocker TT, Huntoon MA, Kopp SL, Rathmell JP, Watson JC. The Second ASRA Practice Advisory on Neurologic Complications Associated With Regional Anesthesia and Pain Medicine: Executive Summary 2015. Reg Anesth Pain Med. 2015;40(5):401-430.  https://doi.org/10.1097/AAP.0000000000000286
  25. Hoefnagel A, Yu A, Kaminski A. Anesthetic Complications in Pregnancy. Crit Care Clin. 2016;32(1):1-28.  https://doi.org/10.1016/j.ccc.2015.08.009
  26. Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, Dunn AS, Kunz R. Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):326-350.  https://doi.org/10.1378/chest.11-2298
  27. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins — Obstetrics. ACOG Practice Bulletin No. 209: Obstetric Analgesia and Anesthesia. Obstet Gynecol. 2019;133(3):208-225.  https://doi.org/10.1097/AOG.0000000000003132
  28. Uprichard J, Manning RA, Laffan MA. Monitoring heparin anticoagulation in the acute phase response. Br J Haematol. 2010;149(4):613-619.  https://doi.org/10.1111/j.1365-2141.2010.08129.x
  29. Zmuda K, Neofotistos D, Ts’ao CH. Effects of unfractionated heparin, low-molecular-weight heparin, and heparinoid on thromboelastographic assay of blood coagulation. Am J Clin Pathol. 2000;113(5):725-731.  https://doi.org/10.1309/Q4AE-BMCW-CQ7J-NUVT
  30. Anticoagulation Management. A Guidebook for Pharmacists. Ed. Anne Rose — Springer International Publishing Switzerland. 2015:274. 
  31. Wu T, Xia X, Chen W, Fu J, Zhang J. The effect of anti-Xa monitoring on the safety and efficacy of low-molecular-weight heparin anticoagulation therapy: A systematic review and meta-analysis. J Clin Pharm Ther. 2020;45(4):602-608.  https://doi.org/10.1111/jcpt.13169
  32. Egan G, Ensom MH. Measuring anti-factor Xa activity to monitor low-molecular-weight heparin in obesity: a critical review. Can J Hosp Pharm. 2015;68(1):33-47.  https://doi.org/10.4212/cjhp.v68i1.1423
  33. Frazer A, Rowland J, Mudge A, Barras M, Martin J, Donovan P. Systematic review of interventions to improve safety and quality of anticoagulant prescribing for therapeutic indications for hospital inpatients. Eur J Clin Pharmacol. 2019;75(12):1645-1657. https://doi.org/10.1007/s00228-019-02752-8
  34. Manresa Ramón N, Nájera Pérez MD, Page del Pozo MÁ, Sánchez Martínez I, Sánchez Catalicio Ma del M, Roldán Schilling V. Establecimiento de un protocolo para el uso de la heparina en pacientes con características especiales [Set up of a protocol for heparin use in special patients]. Farm Hosp. 2014;38(2):135-144. 
  35. Babin JL, Traylor KL, Witt DM. Laboratory Monitoring of Low-Molecular-Weight Heparin and Fondaparinux. Semin Thromb Hemost. 2017; 43(3):261-269.  https://doi.org/10.1055/s-0036-1581129.
  36. Garcia P, Ruiz W, Loza Munárriz C. Warfarin initiation nomograms for venous thromboembolism. Cochrane Database Syst Rev. 2016;1:CD007699. PMID: 26822633. https://doi.org/10.1002/14651858.CD007699.pub3
  37. Tran HA, Chunilal SD, Harper PL, Tran H, Wood EM, Gallus AS; Australasian Society of Thrombosis and Haemostasis (ASTH). An update of consensus guidelines for warfarin reversal. Med J Aust. 2013;198(4):198-199.  https://doi.org/10.5694/mja12.10614
  38. Colarossi G, Schnöring H, Trivellas A, Betsch M, Hatam N, Eschweiler J, Tingart M, Migliorini F. Prognostic factors for patients with heparin-induced thrombocytopenia: a systematic review. Int J Clin Pharm. 2020. https://doi.org/10.1007/s11096-020-01166-2
  39. Junqueira DR, Zorzela LM, Perini E. Unfractionated heparin versus low molecular weight heparins for avoiding heparin-induced thrombocytopenia in postoperative patients. Cochrane Database Syst Rev. 2017;4(4):CD007557. https://doi.org/10.1002/14651858.CD007557.pub3
  40. Gruel Y, De Maistre E, Pouplard C, Mullier F, et al. Members of the French Working Group on Perioperative Haemostasis Groupe d’intérêt en hémostase périopératoire GIHP. Diagnosis and management of heparin-induced thrombocytopenia. Anaesth Crit Care Pain Med. 2020;39(2):291-310.  https://doi.org/10.1016/j.accpm.2020.03.012
  41. Tang J, Lin Y, Mai H, Luo Y, Huang R, Chen Q, Xiao D. Meta-analysis of reference values of haemostatic markers during pregnancy and childbirth. Taiwan J Obstet Gynecol. 2019;58(1):29-35.  https://doi.org/10.1016/j.tjog.2018.11.004
  42. Van der Pol LM, Mairuhu AT, Tromeur C, Couturaud F, Huisman MV, Klok FA. Use of clinical prediction rules and D-dimer tests in the diagnostic management of pregnant patients with suspected acute pulmonary embolism. Blood Rev. 2017;31(2):31-36.  https://doi.org/10.1016/j.blre.2016.09.003
  43. Borsi SH, Shoushtari MH, MalAmir MD, Angali KA, Mavalizadeh MS. Comparison of the D-dimer concentration in pregnant women with or without pulmonary thromboembolism. J Family Med Prim Care. 2020; 9(8):4343-4347. https://doi.org/10.4103/jfmpc.jfmpc_1070_19
  44. Rodríguez-Peña Y, Ibáñez-Pinilla M. Elevated levels of D-dimer tested by immunoturbidimetry are associated with the extent of severity of pre-eclampsia. Int J Gynaecol Obstet. 2020;150(2):241-247.  https://doi.org/10.1002/ijgo.13163
  45. Goodacre S, Horspool K, Nelson-Piercy C, Knight M, et al. DiPEP research group. The DiPEP study: an observational study of the diagnostic accuracy of clinical assessment, D-dimer and chest x-ray for suspected pulmonary embolism in pregnancy and postpartum. BJOG. 2019;126(3):383-392.  https://doi.org/10.1111/1471-0528.15286
  46. McLEAN KC, James AH. Diagnosis and Management of VTE in Pregnancy. Clin Obstet Gynecol. 2018;61(2):206-218.  https://doi.org/10.1097/GRF.0000000000000354
  47. Chan WS. Can pregnancy-adapted algorithms avoid diagnostic imaging for pulmonary embolism? Hematology Am Soc Hematol Educ Program. 2020;2020(1):184-189.  https://doi.org/10.1182/hematology.2020000105
  48. Al Oweidat K, Al Ryalat SA, Al Husban N, Alhawari H, Ghareeb R, Ribie M, Jwaied S, Al Yasjeen S, Juweid ME. Additive evidence of the competence of pregnancy-adapted YEARS algorithm in reducing the need for CTPA, Q and/or V/Q scintiscan. Hell J Nucl Med. 2020;23(2):165-172.  https://doi.org/10.1967/s002449912106
  49. Kerai S, Saxena KN, Wadhwa B. Preoperative pregnancy testing in surgical patients: How useful is policy of routine testing. Indian J Anaesth. 2019;63(10):786-790.  https://doi.org/10.4103/ija.IJA_293_19
  50. Lamb JC, Allen D, Franklin J, Goode V. Evaluation of a Presurgical Pregnancy Testing Protocol at an Ambulatory Surgery Center. J Perianesth Nurs. 2019;34(5):938-945.  https://doi.org/10.1016/j.jopan.2019.03.010
  51. Routine preoperative tests for elective surgery: NICE (2016) Routine preoperative tests for elective surgery. BJU Int. 2018;121(1):12-16.  https://doi.org/10.1111/bju.14079
  52. Maher JL, Mahabir RC. Preoperative pregnancy testing. Can J Plast Surg. 2012;20(3):32-34. 
  53. Pregnancy Testing Prior to Anesthesia and Surgery Committee of Origin: Quality Management and Departmental Administration (Approved by the ASA House of Delegates on October 26, 2016).
  54. Gong X, Poterack KA. Retrospective Review of Universal Preoperative Pregnancy Testing: Results and Perspectives. Anesth Analg. 2018;127(2):4-5.  https://doi.org/10.1213/ANE.0000000000002709
  55. Amgalan A, Allen T, Othman M, Ahmadzia HK. Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendations from the women’s SSC of the ISTH. J Thromb Haemost. 2020;18(8):1813-1838. https://doi.org/10.1111/jth.14882
  56. McLintock C. Prevention and treatment of postpartum hemorrhage: focus on hematological aspects of management. Hematology Am Soc Hematol Educ Program. 2020;2020(1):542-546.  https://doi.org/10.1182/hematology.2020000139
  57. Burton AG, Jandrey KE. Use of Thromboelastography in Clinical Practice. Vet Clin North Am Small Anim Pract. 2020;50(6):1397-1409. https://doi.org/10.1016/j.cvsm.2020.08.001
  58. Tiscia GL, De Laurenzo A, Cappucci F, Favuzzi G, Chinni E, Vaira P, Ostuni A, Margaglione M, Grandone E. Thromboelastography parameters in Italian pregnant women: do antithrombotic drugs change reference values? J Investig Med. 2020;68(4):902-905.  https://doi.org/10.1136/jim-2019-001261
  59. Gold M. Magnetic Resonance Imaging of Spinal Emergencies. Top Magn Reson Imaging. 2015;24(6):325-330.  https://doi.org/10.1097/RMR.0000000000000069
  60. Kawakyu-O’Connor D, Bordia R, Nicola R. Magnetic Resonance Imaging of Spinal Emergencies. Magn Reson Imaging Clin N Am. 2016;24(2):325-344.  https://doi.org/10.1016/j.mric.2015.11.004
  61. Merter A, Shibayama M. A new classification for spinal epidural hematoma following microendoscopic decompressive laminotomy: A prospective clinical and magnetic resonance imaging study of 245 patients. Acta Orthop Traumatol Turc. 2020;54(6):596-603.  https://doi.org/10.5152/j.aott.2020.19181
  62. Keeling D, Tait RC, Watson H; British Committee of Standards for Haematology. Peri-operative management of anticoagulation and antiplatelet therapy. Br J Haematol. 2016;175(4):602-613.  https://doi.org/10.1111/bjh.14344
  63. Irizarry-Alvarado JM, Seim LA. Perioperative Management of Anticoagulants. Curr Clin Pharmacol. 2017;12(3):145-151.  https://doi.org/10.2174/1574884712666170822092709
  64. Sauter TC, Eberle B, Wuillemin WA, Thiele T, Angelillo-Scherrer A, Exadaktylos AK, Erdoes G, Cuker A, Nagler M. How I manage patients with anticoagulation-associated bleeding or urgent surgery. Swiss Med Wkly. 2018;148:w14598. https://doi.org/10.4414/smw.2018.14598
  65. Elmer J, Wittels KA. Emergency reversal of pentasaccharide anticoagulants: a systematic review of the literature. Transfus Med. 2012;22(2):108-115.  https://doi.org/10.1111/j.1365-3148.2011.01125.x
  66. Morotti A, Branca E, Guerrasio A. The Challenge of Hemorrhagic Shock Management During Low-Molecular-Weight Heparin Treatment. J Blood Med. 2020;11:103-105.  https://doi.org/10.2147/JBM.S232109
  67. Yee J, Kaide CG. Emergency Reversal of Anticoagulation. West J Emerg Med. 2019;20(5):770-783.  https://doi.org/10.5811/westjem.2018.5.38235
  68. Simon EM, Streitz MJ, Sessions DJ, Kaide CG. Anticoagulation Reversal. Emerg Med Clin North Am. 2018;36(3):585-601.  https://doi.org/10.1016/j.emc.2018.04.014
  69. Meltzer J, Guenzer JR. Anticoagulant Reversal and Anesthetic Considerations. Anesthesiol Clin. 2017;35(2):191-205.  https://doi.org/10.1016/j.anclin.2017.01.005
  70. Makris M, Van Veen JJ, Tait CR, Mumford AD, Laffan M, The British Committee for Standards in Haematology. Guideline on the management of bleeding in patients on antithrombotic agents. Br J Haematol. 2013;160(1):35-46. First published: 01 November 2012. https://doi.org/10.1111/bjh.12107
  71. Maslin B, Springer E, Zhu R, Kodumudi V, Vadivelu N. Perioperative Safety of Warfarin Therapy and Reversal. Curr Drug Saf. 2016;11(2):149-155.  https://doi.org/10.2174/1574886311666151217121553
  72. McMahon C, Halfpap J, Zhao Q, Bienvenida A, Rose AE. Evaluation of a Fixed-Dose Regimen of 4-Factor Prothrombin Complex Concentrate for Warfarin Reversal. Ann Pharmacother. 2021 Feb 1:1060028021992142. https://doi.org/10.1177/1060028021992142
  73. Nagalla S, Sarode R. Role of Platelet Transfusion in the Reversal of Anti-Platelet Therapy. Transfus Med Rev. 2019;33(2):92-97.  https://doi.org/10.1016/j.tmrv.2019.01.002
  74. Gremmel T, Panzer S. Oral antiplatelet therapy: impact for transfusion medicine. Vox Sang. 2017;112(6):511-517.  https://doi.org/10.1111/vox.12537
  75. Ma’ayeh M, Rood KM, Kniss D, Costantine MM. Novel Interventions for the Prevention of Preeclampsia. Curr Hypertens Rep. 2020;22(2):17.  https://doi.org/10.1007/s11906-020-1026-8
  76. Bongiovanni T, Lancaster E, Ledesma Y, Whitaker E, Steinman MA, Allen IE, Auerbach A, Wick E. Systematic Review and Meta-Analysis of the Association Between Non-Steroidal Anti-Inflammatory Drugs and Operative Bleeding in the Perioperative Period. J Am Coll Surg. 2021:S1072-7515(21)00048-X.  https://doi.org/10.1016/j.jamcollsurg.2021.01.005
  77. Rodriguez D, Jerjes-Sanchez C, Fonseca S, Garcia-Toto R, Martinez-Alvarado J, Panneflek J, Ortiz-Ledesma C, Nevarez F. Thrombolysis in massive and submassive pulmonary embolism during pregnancy and the puerperium: a systematic review. J Thromb Thrombolysis. 2020;50(4):929-941.  https://doi.org/10.1007/s11239-020-02122-7
  78. Terada Y, Toda H, Hashikata H, Yamamoto Y, Nagai Y, Yoshimoto N, Goto M, Nishida N, Iwasaki K. Treatment of Non-Traumatic Spinal Epidural Hematoma:A Report of Five Cases and a Systematic Review of the Literature. No Shinkei Geka. 2016;44(8):669-677. (In Japanese). https://doi.org/10.11477/mf.1436203352
  79. Hewson DW, Bedforth NM, Hardman JG. Spinal cord injury arising in anaesthesia practice. Anaesthesia. 2018;73(Suppl 1):43-50.  https://doi.org/10.1111/anae.14139
  80. American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins — Obstetrics. ACOG Practice Bulletin No. 196: Thromboembolism in Pregnancy. Obstet Gynecol. 2018;132(1):1-17.  https://doi.org/10.1097/AOG.0000000000002706
  81. Zheng J, Chen Q, Fu J, Lu Y, Han T, He P. Critical appraisal of international guidelines for the prevention and treatment of pregnancy-associated venous thromboembolism: a systematic review. BMC Cardiovasc Disord. 2019;19(1):199.  https://doi.org/10.1186/s12872-019-1183-3
  82. Dhillon SK, Edwards J, Wilkie J, Bungard TJ. High-Versus Low-Dose Warfarin-Related Teratogenicity: A Case Report and Systematic Review. J Obstet Gynaecol Can. 2018;40(10):1348-1357. https://doi.org/10.1016/j.jogc.2017.11.020
  83. Eubanks AA, Deering SH, Thiel LM. Risk Assessment and Treatment Guide for Obstetric Thromboprophylaxis: Comprehensive Review of Current Guidelines. Am J Perinatol. 2019;36(2):130-135.  https://doi.org/10.1055/s-0038-1672164
  84. D’Souza R, Ostro J, Shah PS, Silversides CK, Malinowski A, Murphy KE, Sermer M, Shehata N. Anticoagulation for pregnant women with mechanical heart valves: a systematic review and meta-analysis. Eur Heart J. 2017;38(19):1509-1516. https://doi.org/10.1093/eurheartj/ehx032
  85. Fogerty AE. Challenges of Anticoagulation Therapy in Pregnancy. Curr Treat Options Cardiovasc Med. 2017;19(10):76.  https://doi.org/10.1007/s11936-017-0575-x
  86. Côté-Poirier G, Bettache N, Côté AM, Mahone M, Morin F, Cumyn A, Bureau YA, Malick M, Sauvé N. Evaluation of Complications in Postpartum Women Receiving Therapeutic Anticoagulation. Obstet Gynecol. 2020;136(2):394-401.  https://doi.org/10.1097/AOG.0000000000003971
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