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Kosareva A.D.

Sechenov First Moscow State Medical University (Sechenov University)

Novikov V.N.

Sechenov First Moscow State Medical University (Sechenov University)

Mingazova L.R.

Sechenov First Moscow State Medical University (Sechenov University)

Kuznetsova E.B.

Sechenov First Moscow State Medical University (Sechenov University)

Nemtsova M.V.

Sechenov First Moscow State Medical University (Sechenov University)

Artemenko A.R.

Institute of Professional Education, Sechenov First Moscow State Medical University (Sechenov University)

The role of TRP channels in migraine

Authors:

Kosareva A.D., Novikov V.N., Mingazova L.R., Kuznetsova E.B., Nemtsova M.V., Artemenko A.R.

More about the authors

Journal: Russian Journal of Pain. 2025;23(3): 93‑103

DOI: 10.17116/pain20252303193

Read: 352 times

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Table of contents

THE ROLE OF TRP CHANNELS IN MIGRAINE
THE ROLE OF TRP CHANNELS IN MIGRAINE

To cite this article:

Kosareva AD, Novikov VN, Mingazova LR, Kuznetsova EB, Nemtsova MV, Artemenko AR. The role of TRP channels in migraine. Russian Journal of Pain. 2025;23(3):93‑103. (In Russ.)
https://doi.org/10.17116/pain20252303193

 
 
Подписка 2025 Российский журнал боли (Russian Journal of Pain)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze modern data on TRP channel neurobiology, their role in migraine pathogenesis and potential therapeutic significance.

MATERIAL AND METHODS

We reviewed the PubMed, Web of Science, and Scopus databases (2004 — March 2025) and focused on TRPM8, TRPV1, and TRPA1 polymorphisms.

RESULTS

TRP channels are important in fundamental mechanisms of nociception, neurogenic inflammation and chronic pain in migraine through regulation of synthesis and release of CGRP, as well as participating in pain and temperature allodynia. There is a significant association between TRP channel polymorphisms (especially rs10166942 in TRPM8 and rs222741 in TRPV1) and the risk of migraine. Some authors established a correlation of certain genetic variants in the TRP channel genes with clinical characteristics of disease and effectiveness of migraine therapy.

CONCLUSION

Polymorphisms in TRP channel genes are important in pathogenesis of migraine and can be considered as potential prognostic factors for assessing the course of disease and choosing the optimal therapy. Further research is needed to develop personalized treatment approaches.

Keywords:

migraine
TRP channels
genetic polymorphisms
TRPM8
TRPV1
personalized medicine

Authors:

Kosareva A.D.

Sechenov First Moscow State Medical University (Sechenov University)

Novikov V.N.

Sechenov First Moscow State Medical University (Sechenov University)

Mingazova L.R.

Sechenov First Moscow State Medical University (Sechenov University)

Kuznetsova E.B.

Sechenov First Moscow State Medical University (Sechenov University)

Nemtsova M.V.

Sechenov First Moscow State Medical University (Sechenov University)

Artemenko A.R.

Institute of Professional Education, Sechenov First Moscow State Medical University (Sechenov University)

Received:

28.05.2025

Accepted:

10.07.2025

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