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Kolesnikov Yu.A.

Medical Center «Medicum»

Chronic postoperative pain syndrome: where we are in understanding the genetic risk factors, mechanisms and pharmacotherapy?

Authors:

Kolesnikov Yu.A.

More about the authors

Journal: Russian Journal of Pain. 2021;19(3): 53‑58

DOI: 10.17116/pain20211903153

Views: 7665

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Table of contents

CHRONIC POSTOPERATIVE PAIN SYNDROME: WHERE WE ARE IN UNDERSTANDING THE GENETIC RISK FACTORS, MECHANISMS AND PHARMACOTHERAPY?
CHRONIC POSTOPERATIVE PAIN SYNDROME: WHERE WE ARE IN UNDERSTANDING THE GENETIC RISK FACTORS, MECHANISMS AND PHARMACOTHERAPY?

To cite this article:

Kolesnikov YuA. Chronic postoperative pain syndrome: where we are in understanding the genetic risk factors, mechanisms and pharmacotherapy? Russian Journal of Pain. 2021;19(3):53‑58. (In Russ.)
https://doi.org/10.17116/pain20211903153

Подписка 2025-2 (Russian Journal of Pain)
 
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This review is devoted to analysis of modern scientific data on chronic postoperative pain syndrome. According to the authors, the incidence of chronic pain is still high and has changed little since the first publication in the late 1990s. Nevertheless, significant advances have been made in understanding the mechanisms of chronic pain, risk factors and genetic predisposition to chronic pain. Preventive methods are not always effective for this syndrome, and cannot be introduced into routine medical practice. Pharmacotherapy of chronic postoperative pain is widely used. Unfortunately, effectiveness and safety of these combinations do not meet modern requirements for analgesics. Application of local analgesics with different mechanisms of action is one of the alternative methods of treatment that will reduce the dose of systemic drugs. In this context, methods of treatment aimed at peripheral targets look perspective.

Keywords:

chronic postoperative pain
neuropathic pain
pain genetics
local analgesics

Authors:

Kolesnikov Yu.A.

Medical Center «Medicum»

Received:

10.05.2021

Accepted:

17.05.2021

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