Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke

M.V. Zhuravleva

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

ORCID: 0000-0002-9198-8661

I.A. Shchukin

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies of the Federal Medical and Biological Agency of Russia;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0002-6308-9706

M.S. Fidler

Pirogov Russian National Research Medical University;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0001-6464-521X

A.B. Prokofiev

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

S.Yu. Serebrova

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

N.S. Vasyukova

Federal Scientific Center-all-Russian Research Skriabin and Kovalenko Institute of Experimental Veterinary Medicine the Russian Academy of Sciences

E.Yu. Demchenkova

Scientific Center for Examination of Medical Devices

V.V. Arkhipov

Scientific Center for Examination of Medical Devices

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12–2): 60–66

Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke

Authors:

M.V. Zhuravleva, I.A. Shchukin, M.S. Fidler, A.B. Prokofiev, S.Yu. Serebrova, N.S. Vasyukova, E.Yu. Demchenkova, V.V. Arkhipov

More about the authors

DOI: 10.17116/jnevro202012012260

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Zhuravleva MV, Shchukin IA, Fidler MS, Prokofiev AB, Serebrova SYu, Vasyukova NS, Demchenkova EYu, Arkhipov VV. Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(12‑2):60‑66. (In Russ., In Engl.).
https://doi.org/10.17116/jnevro202012012260

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Stroke is still the most significant problem of the modern medicine and the leading cause of mortality and morbidity. There is the great experience of neuroprotection in patients with stroke in the Russian Federation. In clinical practice it’s important to follow conditions, where neuroprotection will have maximum safety and effectiveness. The clinical trials of ethylmethylhydroxypyridine succinate (mexidol) in patients with acute ischemic stroke are described in the present review. Early management (in the first 6 hours) with mexidol significantly improve recovery dynamic and stroke outcome. Therapy with mexidol increases neurological recovery, improves vital activity and quality of life of patients with stroke. Furthermore, mexidol demonstrates high safety profile.

Keywords:

ethylmethylhydroxypyridine succinate

Mexidol

Authors:

M.V. Zhuravleva

I.M. Sechenov First Moscow State Medical University (Sechenov University);
Scientific Centre of Medical Application Expertise of the Ministry of the Healthcare of the Russian Federation

ORCID: 0000-0002-9198-8661

I.A. Shchukin

Pirogov Russian National Research Medical University;
Federal Center of Brain and Neurotechnologies of the Federal Medical and Biological Agency of Russia;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0002-6308-9706

M.S. Fidler

Pirogov Russian National Research Medical University;
Pirogov City Clinical Hospital No. 1

ORCID: 0000-0001-6464-521X

A.B. Prokofiev

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

S.Yu. Serebrova

Scientific Center for Examination of Medical Devices;
Sechenov First Moscow State Medical University

N.S. Vasyukova

Federal Scientific Center-all-Russian Research Skriabin and Kovalenko Institute of Experimental Veterinary Medicine the Russian Academy of Sciences

E.Yu. Demchenkova

Scientific Center for Examination of Medical Devices

V.V. Arkhipov

Scientific Center for Examination of Medical Devices

Received:

23.09.2020

Accepted:

29.10.2020

List of references:

Piradov MA, Tanashjan MM, Maksimova MJu. Insul’t: sovremennye tehnologii diagnostiki i lechenija : rukovodstvo dlja vrachej. M.: MEDpress-inform; 2018. (In Russ.).
Stakhovskaya LV, Kotov SV. Insul’t. Rukovodstvo dlya vrachei. M.: Izdatel’stvo MIA; 2018. (In Russ.).
Stakhovskaya LV, Tyutyumova EA, Fedin AI. Modern approaches to neuroprotective treatment of ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;8:(2):75-80. (In Russ.). https://doi.org/10.17116/jnevro20171178275-80
Stakhovskaya LV, Shamalov NA, Khasanova DR, Melnikova EV, Agafiina AS, Golikov KV, Bogdanov EI, Yakupova AA, Roshkovskaya LV, Lukinykh LV, Lokshtanova TM, Poverennova IE, Shepankevich LA. Results of a randomized double blind multicenter placebo-controlled, in parallel groups trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA). Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2017;117:3(2):55-65. (In Russ.). https://doi.org/10.17116/jnevro20171173255-65
Stakhovskaya LV, Shamalov NA, Khasanova DR, Mel’nikova EV, Agaf’ina AS, Golikov KV, Bogdanov EI, Yakupova AA, Roshkovskaya LV, Lukinykh LV, Lokshtanova TM, Poverennova IE, Shchepankevich LA. Results of a Randomized, Double-Blind, Multicenter, Placebo-Controlled, Parallel-Group Study of the Efficacy and Safety of Mexidol in Prolonged Sequential Therapy of Patients in the Acute and Early Recovery Stages of Hemispheric Stroke (the EPICA study). Neuroscience and Behavioral Physiology. 2018;48:8:. 0097-0549/18/4808-0929, 2018, Springer Science+Business Media, LLC. https://doi.org/10.1007/s11055-018-0652-y
Skvortsova VI, Stakhovskaya LV, Nartsyssov YaR, Bodykhov MK, Kichuck IV, Gudkova YuV, Soldatenkova TD, Kondrasheva TT, Kalinina EV, Novichkova MD, Kerbikov OB. The randomized double-blind placebo-controlled study of efficacy and safety of mexidol in the complex therapy of ischemic stroke in the acute period. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2006;106(18):47-54. (In Russ.).
Lutski MA. An analysis of mexidol efficacy in the complex treatment of patients with ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2010;110(4): 57-59. (In Russ.).
https://doi.org/10.17116/jnevro20181183269-72 Kulay NS, Kovalchuk EY. Assessment of the efficacy of mexidol in the combination with hyperbaric oxygen in acute ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2018;118(3):69-72. (In Russ.).
Izhbuldina GI. Changes in the hemostasis system and free-radical lipid oxidation in the acute stage of ischemic stroke in patients on neuroprotection treatment. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2012;112(3):31-37.
Seregin VI, Dronova TV. The use of mexidol in the intensive treatment of acute severe ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2015;115(3):85-87. (In Russ.). https://doi.org/10.17116/jnevro20151153285-87
Odinak MM, Yanishevskii SN, Tsygan NV, Golokhvastov SYu, Voznyuk IA, Trufanov AG. The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2013;113(12-2):12-17. (In Russ.).
Chefranova ZhYu, Makotrova TA, Udachin VA, Koledintseva EV. Efficacy of mexidol in the combination with thrombolytic therapy in patients with ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2012;112:4:49-52. (In Russ.).
Godunova AR, Rakhimova AA, Leontyeva OI, Talipova IG, Yakhin RM, Musin ShG. An influence of submaximal (submineximal) doses of mexidol on oxidant stress and inflammation in the acute period of ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2018;2: 27-30. (In Russ.). https://doi.org/10.17116/jnevro20181182127-30
Musin SgG. Experience of mexidol using in thrombolytic therapy of ischemic stroke. Bulletin of Experimental Biology and Medicine. Supplement #1. 2012.
Shchepankevich LA, Nicolaev YuA, Dolgova NA. Optimization of hypolipidemic therapy in patients with ischemic stroke and diabetes mellitus. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2016;116:2:42-45. (In Russ.). https://doi.org/10.17116/jnevro20161162142-45
Novikova LB, Sharafutdinova LR, Sharapova KM. The use of mexidol in acute periodof ischemic stroke. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2013;113:9:83-85. (In Russ.).