The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Zalogina A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Uzhegov A.M.

Sechenov First Moscow State Medical University (Sechenov University)

Maksyutova G.G.

Sechenov First Moscow State Medical University (Sechenov University)

Bagratunyan D.Kh.

Sechenov First Moscow State Medical University

Shumeiko T.S.

Sechenov First Moscow State Medical University (Sechenov University)

Yankovsky G.D.

Sechenov First Moscow State Medical University (Sechenov University)

Dornichev V.V.

Sechenov First Moscow State Medical University (Sechenov University)

Aslanukova A.M.

Sechenov First Moscow State Medical University (Sechenov University)

Bagatelia Z.T.

Sechenov First Moscow State Medical University (Sechenov University)

Zhdanova P.A.

Sechenov First Moscow State Medical University (Sechenov University)

Zotov S.E.

Sechenov First Moscow State Medical University (Sechenov University)

Parkhomenko E.K.

Sechenov First Moscow State Medical University (Sechenov University)

Zakharyan E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Kharlamova A.A.

Sechenov First Moscow State Medical University

Arzamasova A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Konovalov A.N.

Burdenko Neurosurgical Center

Blinova E.V.

Sechenov First Moscow State Medical University (Sechenov University)

Dydykin S.S.

Sechenov First Moscow State Medical University (Sechenov University)

Development of a valid experimental animal model for common carotid arteries crossover bypass

Authors:

Zalogina A.A., Uzhegov A.M., Maksyutova G.G., Bagratunyan D.Kh., Shumeiko T.S., Yankovsky G.D., Dornichev V.V., Aslanukova A.M., Bagatelia Z.T., Zhdanova P.A., Zotov S.E., Parkhomenko E.K., Zakharyan E.A., Kharlamova A.A., Arzamasova A.A., Konovalov A.N., Blinova E.V., Dydykin S.S.

More about the authors

Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(4): 12‑21

DOI: 10.17116/operhirurg2025904112

Read: 672 times

Download PDF (RU)
Contact the author
Table of contents

DEVELOPMENT OF A VALID EXPERIMENTAL ANIMAL MODEL FOR COMMON CAROTID ARTERIES CROSSOVER BYPASS
DEVELOPMENT OF A VALID EXPERIMENTAL ANIMAL MODEL FOR COMMON CAROTID ARTERIES CROSSOVER BYPASS

To cite this article:

Zalogina AA, Uzhegov AM, Maksyutova GG, et al. Development of a valid experimental animal model for common carotid arteries crossover bypass. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(4):12‑21. (In Russ.)
https://doi.org/10.17116/operhirurg2025904112

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Impact of Physical Acti­vity on Vari­cose Veins: an Expe­rimental Study. Journal of Venous Diso­rders. 2025;(2):105-112
Mathematical mode­ling of outcomes in patients with clinical combination of ischemic stroke and COVID-19 complicated by multiple organ failure. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):42-49
Deve­lopment of an expe­rimental rabbit model of rhinitis medi­camentosa. Russian Bulletin of Otorhinolaryngology. 2025;(3):46-52
Socio-economic damage caused by elevated low-density lipo­protein cholesterol levels. Medi­cal Technologies. Asse­ssment and Choice. 2025;(2):88-98
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Prediction of mortality in severe ischemic stroke during COVID-19 in patients with multiorgan dysfunction. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):120-127
A clinical case of treating a patient with severe ischemic stroke and cancer. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8):114-117
Early anti­thrombotic protection of the brain in patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):5-10
Resu­lts of the implementation of repe­rfusion technologies in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):32-39
Resu­lts of the inte­rnational multicenter randomized, double-blind, placebo-controlled clinical trial for the evaluation of the effi­cacy and safety of the sequential therapy with ethy­lmethylhydroxypyridine succinate in patients in the acute and early reco­very periods of ischemic stroke (MIR). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(8-2):40-53
Abstract:

OBJECTIVE

To develop and validate an in vivo experimental animal model of carotid-carotid crossover bypass for studying hemodynamics, comparing the effectiveness of different types of bypass grafts (autograft and synthetic graft), and improving microsurgical techniques applicable in neurosurgical and vascular practice.

MATERIAL AND METHODS

Between October 2024 and February 2025, three surgical procedures were performed on Landrace pigs. In two experiments, a 5 mm PTFE GORE-TEX synthetic graft was used as a bypass graft, while in the third, an autograft from the superficial femoral artery was used. The bypass grafts were placed in the retropharyngeal space. Intraoperatively, the patency of the bypass graft and both common carotid arteries (CCA) was assessed, and the blood flow velocity (BFV) was measured using contact Doppler flowmetry (Bioss Angiodin-UK system) before and after bypass grafting.

RESULTS

Patent and functional bypass grafts were achieved in all three experiments. The BFV values in the recipient vessels after surgery were comparable to the baseline values, indicating adequate blood flow compensation. The BFV in the donor (left) CCA remained stable, confirming the absence of hemodynamic compromise. In all cases, the animals remained alert and maintained motor activity in the first three days after the procedure. A progressive reduction in operative time and vessel clamping time was observed, confirming the applicability of the model for training purposes.

CONCLUSION

The presented in vivo model of CCA crossover bypass is reproducible, safe, and clinically relevant. It can be used both for research purposes — to evaluate the hemodynamic characteristics of bypass grafts and model various revascularization conditions — and in educational programs to practice surgical techniques in conditions close to clinical settings.

Keywords:

Ischemic stroke
CCA occlusion
crossover bypass
experimental model
vascular neurosurgery

Authors:

Zalogina A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Uzhegov A.M.

Sechenov First Moscow State Medical University (Sechenov University)

Maksyutova G.G.

Sechenov First Moscow State Medical University (Sechenov University)

Bagratunyan D.Kh.

Sechenov First Moscow State Medical University

Shumeiko T.S.

Sechenov First Moscow State Medical University (Sechenov University)

Yankovsky G.D.

Sechenov First Moscow State Medical University (Sechenov University)

Dornichev V.V.

Sechenov First Moscow State Medical University (Sechenov University)

Aslanukova A.M.

Sechenov First Moscow State Medical University (Sechenov University)

Bagatelia Z.T.

Sechenov First Moscow State Medical University (Sechenov University)

Zhdanova P.A.

Sechenov First Moscow State Medical University (Sechenov University)

Zotov S.E.

Sechenov First Moscow State Medical University (Sechenov University)

Parkhomenko E.K.

Sechenov First Moscow State Medical University (Sechenov University)

Zakharyan E.A.

Sechenov First Moscow State Medical University (Sechenov University)

Kharlamova A.A.

Sechenov First Moscow State Medical University

Arzamasova A.A.

Sechenov First Moscow State Medical University (Sechenov University)

Konovalov A.N.

Burdenko Neurosurgical Center

Blinova E.V.

Sechenov First Moscow State Medical University (Sechenov University)

Dydykin S.S.

Sechenov First Moscow State Medical University (Sechenov University)

Received:

22.07.2025

Accepted:

23.08.2025

Close metadata

References:

  1. Klonaris C, Kouvelos GN , Kafeza M, Koutsoumpelis A, Katsargyris A, Tsigris C. Common carotid artery occlusion treatment: revealing a gap in the current guidelines. Eur J Vasc Endovasc Surg. 2013:46(3):291-298.  https://doi.org/10.1016/j.ejvs.2013.06.006
  2. Brott TG, Halperin JL, Abbara S, et al. 2011 ASA/ACCF/AHA/AANN/AANS/ACR/ASNR/CNS/SAIP/SCAI/SIR/SNIS/SVM/SVS guideline on the management of patients with extracranial carotid and vertebral artery disease: executive summary. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American Stroke Association, American Association of Neuroscience Nurses, American Association of Neurological Surgeons, American College of Radiology, American Society of Neuroradiology, Congress of Neurological Surgeons, Society of Atherosclerosis Imaging and Prevention, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of NeuroInterventional Surgery, Society for Vascular Medicine, and Society for Vascular Surgery. Circulation. (2011;124(4):489-532.  https://doi.org/10.1161/CIR.0b013e31820d8d78
  3. Belczak S, Mulatti GC, Abrão SR, da Silva ES, Aun R, Puech-Leão P, de Luccia N. Common Carotid Artery Occlusion: A Single-Center Experience in 40 Cases. Int J Angiol. 2016;25(1):39-43.  https://doi.org/10.1055/s-0035-1547340
  4. Li ZY, Chen C, Ling C, He HY, Luo L, Li H, Wang H. Surgical procedures including carotid-carotid crossover bypass and ring-stripping hybrid operation for Rile’s type 1A common carotid artery occlusion: an experience of 6 cases. Ann Transl Med. 2020;8(7):439.  https://doi.org/10.21037/atm.2020.03.177
  5. Chen C, Ye Z , Luo L , Guo Y, Chang Y, Ning X, Wang H. Carotid-Carotid Artery Crossover Bypass with a Synthetic Vascular Graft for Symptomatic Type 1A Common Carotid Artery Occlusion. World neurosurg. 2018;111:e286-e293. https://doi.org/10.1016/j.wneu.2017.12.060
  6. Duangprasert G, Chotsakulthong P, Durongkaweroj P, Tantongtip D. Carotid-carotid artery crossover bypass using the Saphenous Vein Graft for symptomatic common carotid artery occlusion: how I do it. Acta Neurochirurgica. 2024;166(1):235.  https://doi.org/10.1007/s00701-024-06144-5
  7. Kathleen J Ozsvath , Sean P Roddy, R Clement Darling 3rd, John Byrne, Paul B Kreienberg, Daniel Choi, Philip S K Paty, Benjamin B Chang, Manish Mehta, Dhiraj M Shah. Carotid-carotid crossover bypass: is it a durable procedure? J Vasc Surg. 2003;37(3):582-585.  https://doi.org/10.1067/mva.2003.128
  8. Gasteratos K, Paladino JR, Akelina Y, Mayer HF. Superiority of living animal models in microsurgical training: beyond technical expertise. Eur J Plast Surg. 2021;44(2):167-176.  https://doi.org/10.1007/s00238-021-01798-1
  9. Mathern N, Yousefian E, Ridwan H, Nikoubashman O, Wiesmann M. Comparison of porcine and human vascular diameters for the optimization of interventional stroke training and research. PloS One. 2022; 17(5):e0268005. https://doi.org/10.1371/journal.pone.0268005
  10. Percie du Sert N, Hurst V, Ahluwalia A. et al. The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS biology. 2020;18(7):e3000410. https://doi.org/10.1371/journal.pbio.3000410
  11. Giancarlo Speranza, Keerthi Harish, Caron Rockman, Mikel Sadek, Glenn Jacobowitz, Karan Garg, Heepeel Chang, Katherine Teter, Thomas S Maldonado. Duplex ultrasound and cross-sectional imaging in carotid artery occlusion diagnosis. J Vasc Surg. 2024;79(3):577-583.  https://doi.org/10.1016/j.jvs.2023.11.029
  12. Phillips P, Poku E, Essat M, Woods HB, Goka EA, Kaltenthaler EC, Shackley P, Walters S, Michaels JA. Systematic review of carotid artery procedures and the volume-outcome relationship in Europe. Br J Surg. 2017;104(10):1273-1283. https://doi.org/10.1002/bjs.10593
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.