Lips enhancement with injectable implants (fillers) is becoming increasingly popular. As a rule, side effects are minimal, light and transient. Though, delayed long-term existing complications may occur, manifesting as a nodule, nodes, granuloma or neovascularization development. The complications are classified according to the severity (mild, moderate, severe), the nature of vascular disorders (ischemic and non-ischemic) and the time of appearance (immediate, early and late). Understanding the effects of lip enhancement with fillers allows clinicians to correctly diagnose and choose the tactics of further patients’ management. Special attention should be paid to the well-collected medical history data. Instrumental methods of examination (dermatoscopy, ultrasound) also have a significant diagnostic value. Solid elements that appear a few months or years after a contour correction may represent foreign body granuloma or simulate other various pathology. A clinical case of delayed complication that simulated an amelanotic melanoma is described. Doctors of different specialties should more carefully collect anamnesis, apply additional methods of examination, as well as know about the possibility of developing delayed complications of fabric fillers injection due to the increase in the number of injectable aesthetic manipulations.