HARDI-CSD tractography in determining the structure of diencephalic pathways in craniopharyngiomas

Ivanov VV, Konovalov AN, Zakharova NE, et al. HARDI-CSD tractography in determining the structure of diencephalic pathways in craniopharyngiomas. Burdenko's Journal of Neurosurgery. 2025;89(1):30‑36. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20258901130

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To determine the possibility of visualizing some structures of chiasmatic-sellar region and third ventricle (hypothalamic-pituitary tract (pituitary stalk), optic pathways, fornix, mammillothalamic tract) using HARDI-CSD tractography in patients with suprasellar craniopharyngiomas, especially after failed CT and standard MRI of these structures.

MATERIAL AND METHODS

A pilot study included 4 patients (2 adults and 2 children) with craniopharyngiomas who underwent surgical treatment at the Burdenko Neurosurgery Center between January and July 2024. Patients underwent MR tractography before and after surgery.

RESULTS

HARDI-CSD tractography reconstructed optic tracts in 3 patients before and after surgery. Simultaneous visualization of several structures (pituitary stalk, fornix, optic tracts) was performed before and after surgery in 1 case. These data were useful for planning surgery and evaluating postoperative outcomes. In one patient, imaging of mammillothalamic tract was obtained after resection of large cystic intra-extraventricular craniopharyngioma.

CONCLUSION

HARDI-CSD tractography provides valuable information about basal cerebral pathways (optic pathways, pituitary stalk, fornix, mammillothalamic tract) when planning and evaluating the results of surgical treatment of craniopharyngiomas.

Keywords:

craniopharyngioma

third ventricle

tractography

neurosurgery

hypothalamus

Authors:

Ivanov V.V.

Burdenko Neurosurgical Center

ORCID: 0000-0003-3827-8676

Konovalov A.N.

Burdenko Neurosurgical Center

ORCID: 0000-0002-1731-6568

Zakharova N.E.

Burdenko Neurosurgical Center

ORCID: 0000-0002-0516-3613

Afandiev R.M.

Burdenko Neurosurgical Center

ORCID: 0000-0001-6384-7960

Pogosbekyan E.L.

Burdenko Neurosurgical Center

ORCID: 0000-0002-4803-6948

Pronin I.N.

Burdenko Neurosurgical Center

SPIN RSCI: 9223-9217
Scopus AuthorID: 7006011755
ORCID: 0000-0002-4480-0275

Shkarubo A.N.

Burdenko Neurosurgical Center

ORCID: 0000-0003-3445-3115

Kalinin P.L.

Burdenko Neurosurgical Center

ORCID: 0000-0001-9333-9473

Received:

18.03.2024

Accepted:

21.11.2024

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References:

Fukui MB, Monroy-Sosa A, Chakravarthi SS, Jennings JE, Rovin RA, Epping A, Kassam AB. Integration of White Matter Tractography in Subcortical and Skull Base Neurosurgical Planning. Principles of Neuro-Oncology. 2021:245-264. https://doi.org/10.1007/978-3-030-54879-7_11
Baev AA, Pogosbekian EL, Zakharova NE, Pitskhelauri DI, Batalov AI, Shkatova AM, Shults EI, Bykanov AE, Maryashev SA, Konakova TA, Pronin IN. Magnetic resonance tractography based on the constrained spherical deconvolution in patients with gliomas of the optic pathway. Almanac of Clinical Medicine. 2021;49(1):11-20. (In Russ.). https://doi.org/10.18786/2072-0505-2021-49-009
Aleksandrova EV, Batalov AI, Pogosbekyan EL, Zakharova NE, Fadeeva LM, Kravchuk AD, Pronin IN, Potapov AA. New opportunities of magnetic-resonance imaging: an algorithm of CSD-HARDI tractography in reconstruction of the brainstem reticular formation fibers. Burdenko’s Journal of Neurosurgery. 2018;82(1):5-12. (In Russ.). https://doi.org/10.17116/oftalma201813415-12
Craniopharyngiomas: educational and methodological manual for doctors. Konovalov AN, ed. Moscow: GEOTAR-Media; 2025. (In Russ.).
Stark KL, Kaufman B, Lee BC, Primack J, Tychsen L. Visual recovery after a year of craniopharyngioma-related amaurosis: Report of a nine-year-old child and a review of pathophysiologic mechanisms. Journal of American Association for Pediatric Ophthalmology and Strabismus. 1999;3(6):366-71. https://doi.org/10.1016/s1091-8531(99)70047-9
Carrozzi A, Gramegna LL, Sighinolfi G, Zoli M, Mazzatenta D, Testa C, Lodi R, Tonon C, Manners DN. Methods of diffusion MRI tractography for localization of the anterior optic pathway: A systematic review of validated methods. Neuroimage: Clinical. 2023;39:103494. https://doi.org/10.1016/j.nicl.2023.103494
Kamali A, Hasan KM, Adapa P, Razmandi A, Keser Z, Lincoln J, Kramer LA. Distinguishing and quantification of the human visual pathways using high-spatial-resolution diffusion tensor tractography. Magnetic resonance imaging. 2014;32(7):796-803. https://doi.org/10.1016/j.mri.2014.04.002
Majchrzak K, Bierzyńska-Macyszyn G, Bobek-Billewicz B, Majchrzak H, Ładziński P. Rare primary tumours of the hypothalamus in adults: clinical course and surgical treatment. Neurologia i neurochirurgia polska. 2010;44(6):546-53. https://doi.org/10.1016/s0028-3843(14)60151-1
Hajiabadi M, Samii M, Fahlbusch R. A preliminary study of the clinical application of optic pathway diffusion tensor tractography in suprasellar tumor surgery: preoperative, intraoperative, and postoperative assessment. Journal of neurosurgery. 2016;125(3):759-65. https://doi.org/10.3171/2015.6.JNS1546
Wang F, Jiang J, Zhang J, Wang Q. Predicting pituitary stalk position by in vivo visualization of the hypothalamo-hypophyseal tract in craniopharyngioma using diffusion tensor imaging tractography. Neurosurgical Review. 2018;41(3):841-849. https://doi.org/10.1007/s10143-017-0933-x
Prieto R, Pascual JM, Barrios L. Topographic Diagnosis of Craniopharyngiomas: The Accuracy of MRI Findings Observed on Conventional T1 and T2 Images. American journal of neuroradiology. 2017;38(11):2073-2080. https://doi.org/10.3174/ajnr.A5361
Pascual JM, Prieto R, Carrasco R, Barrios L. Displacement of mammillary bodies by craniopharyngiomas involving the third ventricle: surgical-MRI correlation and use in topographical diagnosis. Journal of neurosurgery. 2013;119(2):381-405. https://doi.org/10.3171/2013.1.JNS111722
Kutin MA, Sidneva YuG, Konovalov AN, Pronin IN, Kadashev BA, Kalinin PL, Shkarubo AN, Semenova ZhB, Fomichev DV, Sharipov O, Shultz EI, Lubnin AYu, Popugaev KA, Savin IA, Astafieva LI, Klochkova IS, Shishkina LV, Dobrovolsky GF, Rotin DL, Savateev AN. Hypothalamus. modern ideas about spatial and functional organization (Literature review). Bulletin of neurology, psychiatry and neurosurgery. 2016;2:55-65. (In Russ.).
Dillingham CM, Frizzati A, Nelson AJ, Vann SD. How do mammillary body inputs contribute to anterior thalamic function? Neuroscience and biobehavioral reviews. 2015;54:108-19. https://doi.org/10.1016/j.neubiorev.2014.07.025
Kril JJ, Harper CG. Neuroanatomy and neuropathology associated with Korsakoff’s syndrome. Neuropsychology Review. 2012;22(2):72-80. https://doi.org/10.1007/s11065-012-9195-0
Kamali A, Sair HI, Blitz AM, Riascos RF, Mirbagheri S, Keser Z, Hasan KM. Revealing the ventral amygdalofugal pathway of the human limbic system using high spatial resolution diffusion tensor tractography. Brain structure & function. 2016;221(7):3561-9. https://doi.org/10.1007/s00429-015-1119-3
Christiansen K, Aggleton JP, Parker GD, O’Sullivan MJ, Vann SD, Metzler-Baddeley C. The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: An MRI tractography study. Neuroimage. 2016;130:35-47. https://doi.org/10.1016/j.neuroimage.2015.12.055
Kamali A, Sair HI, Blitz AM, Riascos RF, Mirbagheri S, Keser Z, Hasan KM. Revealing the ventral amygdalofugal pathway of the human limbic system using high spatial resolution diffusion tensor tractography. Brain structure & function. 2016;221(7):3561-9. https://doi.org/10.1007/s00429-015-1119-3
Metzler-Baddeley C, Caeyenberghs K, Foley S, Jones DK. Longitudinal data on cortical thickness before and after working memory training. Data in Brief. 2016;7:1143-7. https://doi.org/10.1016/j.dib.2016.03.090
Kamali A, Riascos RF, Pillai JJ, Sair HI, Patel R, Nelson FM, Lincoln JA, Tandon N, Mirbagheri S, Rabiei P, Keser Z, Hasan KM. Mapping the trajectory of the amygdalothalamic tract in the human brain. Journal of neuroscience research. 2018;96(7):1176-1185. https://doi.org/10.1002/jnr.24235
Kamali A, Ghazi Sherbaf F, Rahmani F, Khayat-Khoei M, Aein A, Gandhi A, Shah EG, Sair HI, Riascos RF, Esquenazi Y, Zhu JJ, Keser Z, Hasan KM. A direct visuosensory cortical connectivity of the human limbic system. Dissecting the trajectory of the parieto-occipito-hypothalamic tract in the human brain using diffusion weighted tractography. Neuroscience Letters. 2020;728:134955. https://doi.org/10.1016/j.neulet.2020.134955
Helleringer M, Dorfmüller G, Ferrand-Sorbets S, Taussig D, Blustjan J, Delalande O, Rosenberg S, de Saint Martin A, Bourdillon P, Bulteau C. Vertical parasagittal hemispherotomy: a case report of postoperative mesio-temporal seizures via amygdalofugal pathway. Acta neurochirurgica. 2021;163(10):2833-2836. https://doi.org/10.1007/s00701-021-04836-w
Benear SL, Ngo CT, Olson IR. Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review. Brain connectivity. 2020;10(7):331-354. https://doi.org/10.1089/brain.2020.0749
Staempfli P, Rienmueller A, Reischauer C, Valavanis A, Boesiger P, Kollias S. Reconstruction of the human visual system based on DTI fiber tracking. Journal of magnetic resonance imaging. 2007;26(4):886-93. https://doi.org/10.1002/jmri.21098
Zhang Y, Wan SH, Wu GJ, Zhang XL. Magnetic resonance diffusion tensor imaging and diffusion tensor tractography of human visual pathway. International journal of ophthalmology. 2012;5(4):452-8. https://doi.org/10.3980/j.issn.2222-3959.2012.04.09