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Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovcev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Ulitin A.Yu.

Polenov Russian Neurosurgery Institute

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Intraoperative photodynamic therapy in complex treatment of malignant gliomas

Authors:

Rynda A.Yu., Olyushin V.E., Rostovcev D.M., Zabrodskaya Yu.M., Ulitin A.Yu., Papayan G.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2023;87(1): 25‑34

DOI: 10.17116/neiro20238701125

Read: 5688 times

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Table of contents

INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMPLEX TREATMENT OF MALIGNANT GLIOMAS
INTRAOPERATIVE PHOTODYNAMIC THERAPY IN COMPLEX TREATMENT OF MALIGNANT GLIOMAS

To cite this article:

Rynda AYu, Olyushin VE, Rostovcev DM, Zabrodskaya YuM, Ulitin AYu, Papayan GV. Intraoperative photodynamic therapy in complex treatment of malignant gliomas. Burdenko's Journal of Neurosurgery. 2023;87(1):25‑34. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20238701125

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Treatment of malignant gliomas is an extremely difficult objective associated with difficult choice of correct strategy. Photodynamic therapy is still not the treatment standard in these patients although this approach significantly improves treatment outcomes in surgery of gliomas.

OBJECTIVE

To demonstrate the possibilities of chlorin e6-mediated photodynamic therapy for malignant glial tumors.

MATERIAL AND METHODS

There were 161 patients with malignant supratentorial glial tumors who were treated at the Polenov Russian Neurosurgery Institute between 2009 and 2016. Eighty patients comprised the main group (photodynamic therapy), 81 ones — control group (without photodynamic therapy).

RESULTS

Photodynamic therapy in complex treatment of malignant brain gliomas significantly increases overall survival in patients with Grade III gliomas up to 39.1±5.5 months (control group — 22.8±3.3 months) and Grade IV gliomas up to 20.7±4.7 months (control group — 13.5±2.3 months) (p=0.0002). This method also increases relapse-free period in patients with Grade III gliomas up to 21.7±3.4 months (control group — 15.8±3.1 months) (p=0.0002) and Grade IV gliomas up to 11.1±2.1 months (control group — 8.0±2.3 months) (p=0.0001).

Keywords:

photodynamic therapy
chlorin e6
malignant gliomas
long-term results

Authors:

Rynda A.Yu.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Olyushin V.E.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Rostovcev D.M.

Polenov Russian Neurosurgery Institute — Branch of the Almazov National Medical Research Center

Zabrodskaya Yu.M.

Prof. A.L. Polenov Russian Research Institute of Neurosurgery — Branch V.A. Almazov National Medical Research Center of the Ministry of Health of Russia

Ulitin A.Yu.

Polenov Russian Neurosurgery Institute

Papayan G.V.

Pavlov First St. Petersburg State Medical University;
Almazov National Medical Research Center

Received:

24.09.2022

Accepted:

18.11.2022

Close metadata

References:

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