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Furtsev T.V.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Savelyeva E.E.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Storozhenko S.E.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Efremov A.A.

Institute of Space Technologies FRC KSC SB RAS, Krasnoyarsk, Russia

Saukh L.N.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Kornaukhov A.I.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Makhmudova F.T.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Kotikov R.A.

Krasnoyarsk Interdistrict Clinical Emergency Hospital named after N.S. Karpovich, Krasnoyarsk, Russia

Experimental study of regenerative processes in the periodontium in response to photodynamic therapy in combination with various photosensitizers

Authors:

Furtsev T.V., Savelyeva E.E., Storozhenko S.E., Efremov A.A., Saukh L.N., Kornaukhov A.I., Makhmudova F.T., Kotikov R.A.

More about the authors

Journal: Russian Journal of Stomatology. 2026;19(1): 36‑42

DOI: 10.17116/rosstomat20261901136

Read: 425 times

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Table of contents

EXPERIMENTAL STUDY OF REGENERATIVE PROCESSES IN THE PERIODONTIUM IN RESPONSE TO PHOTODYNAMIC THERAPY IN COMBINATION WITH VARIOUS PHOTOSENSITIZERS
EXPERIMENTAL STUDY OF REGENERATIVE PROCESSES IN THE PERIODONTIUM IN RESPONSE TO PHOTODYNAMIC THERAPY IN COMBINATION WITH VARIOUS PHOTOSENSITIZERS

To cite this article:

Furtsev TV, Savelyeva EE, Storozhenko SE, et al. Experimental study of regenerative processes in the periodontium in response to photodynamic therapy in combination with various photosensitizers. Russian Journal of Stomatology. 2026;19(1):36‑42. (In Russ.)
https://doi.org/10.17116/rosstomat20261901136

Подписка 2026 Российская стоматология (Russian Journal of Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the regenerative potential of photodynamic therapy using hypericin-based gels at different concentrations (0.1%, 0.5%, 1%) compared to Fotoditazin and a placebo gel in an experimental periodontitis model.

MATERIALS AND METHODS

The experiment was conducted on 40 male Wistar rats with modeled periodontitis. The animals were divided into 5 groups depending on the photosensitizer applied. On day 7, histological and histomorphometric examination of the periodontal soft and hard tissues was performed, assessing the inflammatory infiltrate, angiogenesis, and epithelization.

RESULTS

The use of hypericin gels at concentrations of 0.5% and 1% led to a significant (p<0.01) increase in angiogenesis and epithelization scores (2 points on the semi-quantitative scale) compared to the other groups. A significant predominance of histiocytes and fibroblasts, along with a decrease in the numerical density of lymphocytes, was revealed in these groups. No significant effect on bone tissue parameters was detected on day 7.

CONCLUSION

Hypericin-based gels at concentrations of 0.5% and 1% showed a significant advantage in stimulating the regeneration of periodontal soft tissues, confirming their promise for further preclinical and clinical studies.

Keywords:

photodynamic therapy
periodontitis
hypericin
photosensitizer
regeneration

Authors:

Furtsev T.V.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Savelyeva E.E.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Storozhenko S.E.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Efremov A.A.

Institute of Space Technologies FRC KSC SB RAS, Krasnoyarsk, Russia

Saukh L.N.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Kornaukhov A.I.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Makhmudova F.T.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University Ministry of Health of the Russian Federation, Krasnoyarsk, Russia

Kotikov R.A.

Krasnoyarsk Interdistrict Clinical Emergency Hospital named after N.S. Karpovich, Krasnoyarsk, Russia

Received:

10.11.2025

Accepted:

24.12.2025

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References:

  1. Kaplan MA, Kapinus VN, Yaroslavtseva-Isayeva EV et al. Photodynamic therapy: development of methods and clinical applications in FCI MRRC MOH. Photodynamic therapy and photodyagnosis. 2014;3(1):8-15. (In Russ.). EDN:SKFZNN
  2. Stranadko EF. Main stages of development of photodynamic therapy in Russia. Photodynamic therapy and photodyagnosis. 2015;4(1):3-10. (In Russ.). https://doi.org/10.24931/2413-9432-2015-4-1-3-10
  3. Romanenko IG, Bobkova SA, Dzherelei AA, Kryuchkov DY, Chepurova NI, Bobkov EO. Effectiveness of photodynamic therapy in the treatment of oral lichen planus at dental practice//Herald of physiotherapy and health resort therapy. 2024;30(1):13-19. (In Russ.). EDN:BFDCPZ
  4. Risovannaya ON, Andreasyan TSh. Photodynamic therapy — modern views and innovations in dentistry//Medical alphabet. 2024;(18):78-84. (In Russ.). https://doi.org/10.33667/2078-5631-2024-18-78-84
  5. Estrin NE, Aoki A, Sculean A et al. Lasers in Surgical Therapy of Peri-implantitis. In: Romanos GE, ed // Saving Dental Implants. 2024. https://doi.org/10.1002/9781119807049.ch13
  6. de Souza Rastelli AN. Antimicrobial Photodynamic Therapy (aPDT) as a Disinfection and Biomodulation Approach in Implant Dentistry // Photochemistry and Photobiology. 2021;97(5):1155-1160. https://doi.org/10.1111/php.13509
  7. Hamblin MR. Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes // Current Opinion in Microbiology. 2016; 33:67-73.  https://doi.org/10.1016/j.mib.2016.06.008
  8. Choe R, Balhaddad AA, Fisher JP et al. Photodynamic Therapy for Biomodulation and Disinfection in Implant Dentistry: Is It Feasible and Effective? // Photochemistry and Photobiology. 2021;97(5):916-929.  https://doi.org/10.1111/php.13434
  9. Rabinovich IM, Velichko IV. Photodynamic therapy for treatment of caries//Clinical Dentistry (Russia). 2012;3(63):8-11. (In Russ.). EDN:SXUHOR
  10. Furtsev TV, Lipetskaya EA, Kolenchukova OA. The comparison of «Consepsis» and the method of photodynamic therapy for bacterial treatment of carious cavity//Russian Journal of Dentistry. 2012;(6):15-18. (In Russ.). EDN:PUNBEL
  11. Plotino G, Grande NM, Mercade M. Photodynamic therapy in endodontics // International Endodontic Journal. 2019;52(6):760-774.  https://doi.org/10.1111/iej.13057
  12. Orehova LJu, Loboda ES//Stomatology. 2016;95(6-2):38-39. (In Russ.). EDN:XWRDMH
  13. Hormdee D, Tarawadee N, Rinsathorn W et al. The Effect of Subgingival Curcumin Gel With and Without Photodynamic Therapy as Adjunctive Periodontal Treatment in Type 2 Diabetes Mellitus Patients: A Split-Mouth Clinical and Microbiological Study // International Journal of Dentistry. 2025; 2025:2575672. https://doi.org/10.1155/ijod/2575672
  14. Chausskaya IYu, Nikogosova DE, Kozlikina EI, Meliev DI, Amrieva MS, Drobyshev AYu. Photodynamic therapy with curcumin-based photosensitizer for treatment of gingivitis//Clinical Dentistry (Russia). 2023;26(1): 92-97. (In Russ.). https://doi.org/10.37988/1811-153X_2023_1_92
  15. Losev FF, Krechina EK, Tarasova MM et al. The effectiveness of photodynamic effects on the clinical and functional state of periodontal tissues in periodontitis//Stomatology. 2024;103(4):5-9. (In Russ.). https://doi.org/10.17116/stomat20241030415
  16. Korshunova OV, Plekhova NG. Photodynamic therapy in oncology: Present and future//Pacific Medical Journal. 2020;(4):15-19. (In Russ.). https://doi.org/10.34215/1609-1175-2020-4-15-19
  17. Hu J, Song J, Tang Z et al. Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis // European Journal of Pharmacology. 2021;900:174071. https://doi.org/10.1016/j.ejphar.2021.174071
  18. Lukiyanets EA. Search for new photosensitizers in photodynamic therapy//Photodynamic Therapy and Photodyagnosis. 2013;2(3):3-16. (In Russ.). EDN:SKFDZX
  19. Dempster DW, Compston JE, Drezner MK et al. Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee // J Bone Miner Res. 2013;28(1):2-17.  https://doi.org/10.1002/jbmr.1805
  20. Morgan CJ. Use of proper statistical techniques for research studies with small samples // Am J Physiol Lung Cell Mol Physiol. 2017;313(5):L873-L877. https://doi.org/10.1152/ajplung.00238.2017
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